Radicaux d'addition d'hydrogene dans la thymidine et la thymidine 5′-monophosphate photosensibilisees par la proflavine. Protection par des composes soufres

Chemotherapy-induced hair loss is one of the most serious and feared adverse effects of cancer therapy. Almost all traditional chemotherapeutic agents induce a more or less severe alopecia. At present, there is no effective treatment capable of preventing this damage. Several different experimental approaches, using various animal models, have been investigated over the last years, with promising results. Sulphur-containing amino acids (cystine, cysteine) are essential components for the health of normal hair. L-Cystine is used in the treatment of various forms of alopecia. Vitamin B6 plays an important role in the development and maintenance of the skin and it is useful in reducing hair loss. In the present study, we demonstrated that the combined oral administration at high dosages of L-cystine (1,600 or 800 mg/kg body weight/day) and vitamin B6 (160 or 80 mg/kg body weight/day) is an effective chemopreventive treatment against alopecia induced by doxorubicin treatment (1.1 mg/kg body weight intravenously) in C57BL/6 mice.

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Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of l-cystine and vitamin B6

D’Agostini

Fiallo

Ghio

et al. 2012

Arch Dermatol Res

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Formation Photosensibilisée du Radical Anion du Psoralène

Cannistraro¹,

Vorst

1978

International Journal of Radiation Biology and Related Studies

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Proflavine Photosensitization of Double and Single Stranded Dna: Epr Study of the Effect of Various Sulphur‐containing Substances

Piette

Calberg-Bacq

Vorst

1978

Photochem & Photobiology

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Abstract—The proflavine‐mediated photosensitization of both double‐stranded calf thymus and single‐stranded DNA from bacteriophage φ× 174 was followed in terms of the induction of free radicals in frozen solutions by EPR measurements in the presence of oxygen. The effect of the addition of various sulphur‐containing substances to the proflavine DNA mixtures was studied and quantitatively expressed for definite amounts of proflavine bound to both DNAs. Upon irradiation with visible light, RS radicals were observed in the presence of these sulphur‐containing substances. Some of them caused a decrease in the amount of peroxide radicals normally induced in the photosensitized DNA. This decrease appeared to be linked to the property of the compounds to interact with DNA in such a way that they modify the binding of proflavine to DNA. Cysteine, cysteamine, cystamine and cystine, protect calf thymus DNA against the “proflavine and light” free radical induction by 55, 58, 64 ahd 62% respectively. φ× 174 single‐stranded DNA is also protected by the addition of cysteamine and cystamine, although to a lesser extent than calf thymus DNA (35%). These protection factors were measured under conditions where strong binding of the dye to the DNA was predominant.

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Radicaux d'addition d'hydrogene dans la thymidine et la thymidine 5′-monophosphate photosensibilisees par la proflavine. Protection par des composes soufres

Cited by 3 publications

References 17 publications

Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of l-cystine and vitamin B6

Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of l-cystine and vitamin B6

Formation Photosensibilisée du Radical Anion du Psoralène

Proflavine Photosensitization of Double and Single Stranded Dna: Epr Study of the Effect of Various Sulphur‐containing Substances

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