Radio-decontamination efficacy and safety studies on optimized decontamination lotion formulation

Rana, Shilpa; Bhatt, Siddharth; Dutta, Mita; Khan, Abdul Wadood; Ali, Javed; Sultana, Sarwat; Ansari, S. H.; Sharma, Rakesh Kumar

doi:10.1016/j.ijpharm.2012.05.003

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…Over recent years, new products have become available as “decontaminating agents” for radionuclides, including actinides, and each claims to be highly effective (Xu et al 2008; Rana et al 2012; Grivès et al 2017). However, to date, no experimental model seems suitable to evaluate the efficacy of these new compounds in comparison to existing ones.…”

Section: Introductionmentioning

confidence: 99%

“…However, to date, no experimental model seems suitable to evaluate the efficacy of these new compounds in comparison to existing ones. Decontamination of actinide-contaminated healthy skin has been studied in a number of ex vivo/in vitro models ranging from human or animal stratum corneum preparations; full thickness pig, bovine or human skin; as well as in vivo approaches, mainly using rat (Gerasimo et al 1997; Tymen et al 2000; Houpert et al 2004; Rana et al 2012; Mannis and Brandl 2015; Grivès et al 2017; Sharma et al 2017; Tazrart et al 2018). Probably the most well-known is the use of pig skin obtained from the ears or abdomen and placed in the Franz diffusion cell system.…”

Section: Introductionmentioning

confidence: 99%

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A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo

Griffiths

Devilliers

Laroche³

et al. 2021

Health Physics

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Decontamination of skin is an important medical countermeasure in order to limit potential internal contamination by radionuclides such as actinides. Minimizing skin surface contamination will ultimately prevent internal contamination and subsequent committed effective dose as well as contamination spreading. The decontamination agents tested on a rat skin ex vivo model ranged from water to hydrogel wound dressings. A surfactantcontaining cleansing gel and calixarene nanoemulsion with chelation properties demonstrated marked decontamination efficacies as compared with water or the chelator DTPA. Based on efficacy to remove different actinide physicochemical forms from skin, the results demonstrate that all products can remove the more soluble forms, but a further component of emulsifying or tensioactive action is required for less soluble forms. This indicates that for practical purposes, successful decontamination will depend on identification of the actinide element, the physicochemical form, and possibly the solvent. This study offers a simple, quick, cheap, reproducible screening method for efficacy evaluation of multiple products for removal of a variety of contaminants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo

Griffiths

Devilliers

Laroche³

et al. 2021

Health Physics

View full text Add to dashboard Cite

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“…Multiple readings were taken and the average was used as the background level and subtracted from all measurements. Results of DE were calculated for each radioisotope at different time intervals and compared with placebo (untreated water) 32 …”

Section: Discussionmentioning

confidence: 99%

“…Results of DE were calculated for each radioisotope at different time intervals and compared with placebo (untreated water). 32 It is important to note that DTPA solution ($25%) has been approved for skin decontamination. The concentration of DTPA was reduced to 0.5% to 1.0% in the present study and found to be effective and safe.…”

Section: Evaluation Of Radiation Decontamination Formulationmentioning

confidence: 99%

Scintigraphic Evaluation of Decontamination Lotion for Removal of Radioactive Contamination From Skin

Rana

Dutta

Sharma

et al. 2014

Disaster med. public health prep.

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The formulated lotion assisted in the effective removal of radiocontaminants by decontaminating the radionuclides. Moreover, minimal and easily manageable radioactive waste was generated by this process. Further investigation regarding the infusion of formulated lotion into ready-to-use skin wipes for self-decontamination may be useful for mass casualty scenarios. (Disaster Med Public Health Preparedness. 2014;0:-).

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“…Several formulations for decontamination are commercially available and have been evaluated for their relative efficiency on the skin and on surfaces such as personnel clothing, patient beds, and vinyl-based flooring (13)(14)(15)(16). Nevertheless, validation of the qualifications of various surface materials for inclusion in the design of a radiopharmacy is a step forward in accomplishing the objectives of ALARA and good manufacturing practices.…”

mentioning

confidence: 99%

Radioactivity Decontamination of Materials Commonly Used as Surfaces in General-Purpose Radioisotope Laboratories

Leonardi

Tesan

Zubillaga

et al. 2014

Journal of Nuclear Medicine Technology

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In accord with as-low-as-reasonably-achievable and goodmanufacturing-practice concepts, the present study evaluated the efficiency of radioactivity decontamination of materials commonly used in laboratory surfaces and whether solvent spills on these materials affect the findings. Methods: Four materials were evaluated: stainless steel, a surface comprising one-third acrylic resin and two-thirds natural minerals, an epoxy cover, and vinyl-based multipurpose flooring. Radioactive material was eluted from a 99 Mo/ 99m Tc generator, and samples of the surfaces were control-contaminated with 37 MBq (100 μL) of this eluate. The same procedure was repeated with samples of surfaces previously treated with 4 solvents: methanol, methyl ethyl ketone, acetone, and ethanol. The wet radioactive contamination was allowed to dry and then was removed with cotton swabs soaked in soapy water. The effectiveness of decontamination was defined as the percentage of activity removed per cotton swab, and the efficacy of decontamination was defined as the total percentage of activity removed, which was obtained by summing the percentages of activity in all the swabs required to complete the decontamination. Results: Decontamination using our protocol was most effective and most efficacious for stainless steel and multipurpose flooring. Moreover, treatment with common organic solvents seemed not to affect the decontamination of these surfaces. Decontamination of the other two materials was less efficient and was interfered with by the organic solvents; there was also great variability in the overall results obtained for these other two materials. Conclusion: In expanding our laboratory, it is possible for us to select those surface materials on which our decontamination protocol works best. Deal ing with open sources of radioactivity in the radiopharmacy is a daily task. For that reason, contamination due to radioactive spills may be as frequent as or more frequent than in other areas of the nuclear medicine department or other radioactive facilities (1). The main consequences of contamination of the radiopharmacy working surfaces are an increase in the radiation exposure of personnel (2,3) and the possibility that their hands, face, and outer clothing will be contaminated (4-6). Furthermore, such external contamination may allow radioactive material to enter the systemic circulation and then be taken up by organs. In addition, the contamination of surfaces is an important issue because it may facilitate cross contamination of reactive products handled in the radiopharmacy. Therefore, contamination constitutes a risk to the health of exposed workers and its removal is the most straightforward approach to reducing such a hazard. Nuclear and health regulations reinforce the requirements for decontamination and cleaning procedures based both on principles of radiation protection, such as ALARA (as low as reasonably achievable), and good manufacturing and laboratory practices (7-12).Several formulations for decontamination are commercially av...

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Radio-decontamination efficacy and safety studies on optimized decontamination lotion formulation

Cited by 8 publications

References 26 publications

A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo

A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo

Scintigraphic Evaluation of Decontamination Lotion for Removal of Radioactive Contamination From Skin

Radioactivity Decontamination of Materials Commonly Used as Surfaces in General-Purpose Radioisotope Laboratories

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