Radio Frequency Heating of Implanted Tissue Engineered Scaffolds: Simulation and Experimental Studies

Izadifar, Mohammad; Chen, Daniel

doi:10.5098/hmt.v3.4.3004

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Furthermore, in a scaffold with a thermo-responsive polymeric particulate delivery system, the release of a GF can be temporally controlled by oscillating the external stimuli (Mr, RF/MW, ultrasound) leading to fractional release of GF during tissue regeneration within the scaffold (figure 8(f)). Experimental and computational studies on RF-induced heating of chitosan scaffolds for controlling spatiotemporal temperature distribution within implanted scaffolds have been recently done by Izadifar and Chen (2012) [141]. The heat transfer simulation results from their study suggest that periodic RF heating of chitosan scaffolds can be potentially used to temporally trigger GF release from thermo-responsive polymeric particulate delivery system in the scaffolds.…”

Section: Temperature-triggered Delivery Systemsmentioning

confidence: 99%

Rate-programming of nano-particulate delivery systems for smart bioactive scaffolds in tissue engineering

et al. 2014

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Development of smart bioactive scaffolds is of importance in tissue engineering, where cell proliferation, differentiation and migration within scaffolds can be regulated by the interactions between cells and scaffold through the use of growth factors (GFs) and extra cellular matrix peptides. One challenge in this area is to spatiotemporally control the dose, sequence and profile of release of GFs so as to regulate cellular fates during tissue regeneration. This challenge would be addressed by rate-programming of nano-particulate delivery systems, where the release of GFs via polymeric nanoparticles is controlled by means of the methods of, such as externally-controlled and physicochemically/architecturally-modulated so as to mimic the profile of physiological GFs. Identifying and understanding such factors as the desired release profiles, mechanisms of release, physicochemical characteristics of polymeric nanoparticles, and externally-triggering stimuli are essential for designing and optimizing such delivery systems. This review surveys the recent studies on the desired release profiles of GFs in various tissue engineering applications, elucidates the major release mechanisms and critical factors affecting release profiles, and overviews the role played by the mathematical models for optimizing nano-particulate delivery systems. Potentials of stimuli responsive nanoparticles for spatiotemporal control of GF release are also presented, along with the recent advances in strategies for spatiotemporal control of GF delivery within tissue engineered scaffolds. The recommendation for the future studies to overcome challenges for developing sophisticated particulate delivery systems in tissue engineering is discussed prior to the presentation of conclusions drawn from this paper.

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Section: Temperature-triggered Delivery Systemsmentioning

confidence: 99%

Rate-programming of nano-particulate delivery systems for smart bioactive scaffolds in tissue engineering

et al. 2014

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“…The issue of lack of nutrients, specifically for the inner parts of the scaffolds, has been extensively discussed elsewhere (Izadifar, 2013). To address this issue, radio frequency heating has been used to accelerate the biodegradation of scaffolds and create a pathway for nutrient perfusion (Izadifar and Chen, 2013). A recent review discusses the challenge of how to match the degradation rate of scaffolds with the growth of native tissue (Yang et al, 2017).…”

Section: 2-potential Biomaterials Used In the Fabrication Of Hybrid Scaffoldsmentioning

confidence: 99%

Dispensing-based bioprinting of mechanically-functional hybrid scaffolds with vessel-like channels for tissue engineering applications – A brief review

Naghieh

Sarker

Izadifar

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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Over the past decades, significant progress has been achieved in the field of tissue engineering (TE) to restore/repair damaged tissues or organs and, in this regard, scaffolds made from biomaterials have played a critical role. Notably, recent advances in biomaterials and three-dimensional (3D) printing have enabled the manipulation of two or more biomaterials of distinct, yet complementary, mechanical and/or biological properties to form so-called hybrid scaffolds mimicking native tissues. Among various biomaterials, hydrogels synthesized to incorporate living cells and/or biological molecules have dominated due to their hydrated tissue-like environment. Moreover, dispensing-based bioprinting has evolved to the point that it can now be used to create hybrid scaffolds with complex structures. However, the complexities associated with multi-material bioprinting and synthesis of hydrogels used for hybrid scaffolds pose many challenges for their fabrication. This paper presents a brief review of dispensing-based bioprinting of hybrid scaffolds for TE applications. The focus is on the design and fabrication of hybrid scaffolds, including imaging techniques, potential biomaterials, physical architecture, mechanical properties, cell viability, and the importance of vessel-like channels. The key issues and challenges for dispensing-based bioprinting of hybrid scaffolds are also identified and discussed along with recommendations for future research directions. Addressing these issues will significantly enhance the design and fabrication of hybrid scaffolds to and pave the way for translating them into clinical applications.

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Radio Frequency Heating of Implanted Tissue Engineered Scaffolds: Simulation and Experimental Studies

Abstract: ABSTRACT

Cited by 2 publications

References 12 publications

Rate-programming of nano-particulate delivery systems for smart bioactive scaffolds in tissue engineering

Rate-programming of nano-particulate delivery systems for smart bioactive scaffolds in tissue engineering

Dispensing-based bioprinting of mechanically-functional hybrid scaffolds with vessel-like channels for tissue engineering applications – A brief review

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