Radio-isotope scanning in the diagnosis of pancreatic disease

Abstract

SUMMARYThe results of 117 pancreatic scans using selenomethionine 75 are presented in conjunction with a report on a series of experiments undertaken to investigate the metabolism of selenomethionine. The total plasma radioactivity and plasma protein-bound activity in bile were monitored within the period of time taken by a pancreatic scan. A further investigation was also undertaken in order to find out into which plasma protein selenomethionine became incorporated during this time. The result of these experiments are presented with a discussion on the clinical application of pancreatic scanning and the usefulness of prescan preparations of the patient.

An evaluation of 75Se Selenomethionine scanning as a test of pancreatic function compared with the secretin-pancreozymin test

“…Laparotomy findings interpreted by the same surgical team were available in 57 patients. The secretin-pancreozymin test (Burton, Evans, Harper, Howat, Oleesky, Scott, and Varley, 1960) and the 75Se Selenomethionine scan of the pancreas (Charlesworth, Testa, Pullan, and Torrance, 1970) were usually performed within a week of each other. In each case liver scanning using 99m Technetium colloid was carried out before the pancreatic scan.…”

Pancreatic Synthetic Rates: A New Test of Pancreatic Function

“…In any case, an intravenous injection of a bolus dose of 15Semethionine is rapidly cleared from the circulation, so that this type of administration is not suitable for measuring the rate of incorporation into exocrine secretions, since steady-state plasma levels of the free amino acid are not achieved (8).…”