Radio Pet Therapy of Healthy Wistar Rats with <sup>64</sup>CuCl<sub>2</sub> Labeled to <sup>64</sup>Cu(AcAc)<sub>2</sub> Supported in Functionalized TiO<sub>2</sub> Nanoparticles

Abstract

In recent years Copper-64 in the chemical form of copper chloride ([ 64 Cu]CuCl 2 ) has been identified as a potential agent for PET imaging and radionuclide therapy. The aim of this research was to determine the biodistribution and the labeling of radio nanoparticle with 64 CuCl 2 , the nanoparticles Cu(acac) 2 /F-TiO 2 were mixed with 64 CuCl 2 (20-37 MBq), then the final solution was used to injected healthy Wistar rats to probe the absorption of nanoparticle inside tissue trough of the groups OH that are formed during the functionalization of the Cu(acac) 2 /F-TiO 2 . The "in vivo" evaluation after realize the images study in micro PET equipment, uptake of the radio-nanoparticle was observed in the digestive system in the healthy Wistar rats.