Radio-sensitization efficacy of gold nanoparticles in inhalational nanomedicine and the adverse effect of nano-detachment due to coating inactivation

Gadoue, Sherif M.; Toomeh, Dolla

doi:10.1016/j.ejmp.2019.02.013

Cited by 13 publications

(5 citation statements)

References 41 publications

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“…Also, it has been identified that AuNPs enhanced a multimodal synergistic cancer therapy strategy by co-delivering thermo-chemo-radio therapy [20] . Besides, radio-sensitization efficacy of AuNPs has been clarified in inhalational nanomedicine of lung cancer treatment [21] . Furthermore, Pandey et al uncovered that AuNPs enhanced radio-sensitization of lewis lung cancer cells by diminishing cell survival, which was coincident with our result [22] .…”

Section: Discussionmentioning

confidence: 99%

Radiosensitizing effect of gold nanoparticle loaded with small interfering RNA-SP1 on lung cancer

Zhou¹,

Jiang²,

Gu³

et al. 2021

Translational Oncology

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Highlights siRNA-SP1-loaded AuNPs (AuNPs-si-SP1) inhibits SP1 expression in lung cancer cells. GZMB expression is elevated by silencing SP1 in lung cancer cells. AuNPs-si-SP1 combined with radiotherapy inhibits lung cancer growth effectively. AuNPs-si-SP1 enhances radiosensitivity of lung cancer via SP1/GZMB axis. AuNPs-si-SP1 provides a novel target for radiotherapy of lung cancer.

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Section: Discussionmentioning

confidence: 99%

Radiosensitizing effect of gold nanoparticle loaded with small interfering RNA-SP1 on lung cancer

Zhou¹,

Jiang²,

Gu³

et al. 2021

Translational Oncology

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“…Zhongli Cai's team found that the dose enhancement ratio of GNPs was lower in 3D culture models compared to singlemonolayer (1.3 vs 1.6) (17). Sherif et al argued that the common algorithm for calculating the dose enhancement ratio is overly simplistic and fails to consider specific profiles, leading to a decrease in the dose enhancement ratio due to potential rupture and detachment of GNPs' surface coating (18). Therefore, optimizing the surface coating of GNPs was crucial, although it would certainly be better if the models were more closely aligned with the actual lung environment.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Application of nano-radiosensitizers in non-small cell lung cancer

Hu,

Pang

et al. 2024

Front. Oncol.

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Radiotherapy stands as a cornerstone in the treatment of numerous malignant tumors, including non-small cell lung cancer. However, the critical challenge of amplifying the tumoricidal effectiveness of radiotherapy while minimizing collateral damage to healthy tissues remains an area of significant research interest. Radiosensitizers, by methods such as amplifying DNA damage and fostering the creation of free radicals, play a pivotal role in enhancing the destructive impact of radiotherapy on tumors. Over recent decades, nano-dimensional radiosensitizers have emerged as a notable advancement. Their mechanisms include cell cycle arrest in the G2/M phase, combating tumor hypoxia, and others, thereby enhancing the efficacy of radiotherapy. This review delves into the evolving landscape of nanomaterials used for radiosensitization in non-small cell lung cancer. It provides insights into the current research progress and critically examines the challenges and future prospects within this burgeoning field.

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“…In cancer therapy, these carriers have been of keen interest as they are used in radiotherapy, PTT, and as drug carriers. These carriers, upon inhalation, accumulate in the lungs, which can be effective to treat lung cancer (Gadoue & Toomeh, 2019 ). On the topic, there is a recent review article available (Sztandera et al, 2019 ).…”

Section: Surface-engineered Smart Nanocarriers and Targeted Inhalational Lung Cancer Chemotherapymentioning

confidence: 99%

Surface-engineered smart nanocarrier-based inhalation formulations for targeted lung cancer chemotherapy: a review of current practices

Xue

Shou

2021

Drug Delivery

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Lung cancer is the second most common and lethal cancer in the world. Chemotherapy is the preferred treatment modality for lung cancer and prolongs patient survival by effective controlling of tumor growth. However, owing to the nonspecific delivery of anticancer drugs, systemic chemotherapy has limited clinical efficacy and significant systemic adverse effects. Inhalation routes, on the other hand, allow for direct delivery of drugs to the lungs in high local concentrations, enhancing their anti-tumor activity with minimum side effects. Preliminary research studies have shown that inhaled chemotherapy may be tolerated with manageable adverse effects such as bronchospasm and cough. Enhancing the anticancer drugs deposition in tumor cells and limiting their distribution to other healthy cells will therefore increase their clinical efficacy and decrease their local and systemic toxicities. Because of the controlled release and localization of tumors, nanoparticle formulations are a viable option for the delivery of chemotherapeutics to lung cancers via inhalation. The respiratory tract physiology and lung clearance mechanisms are the key barriers to the effective deposition and preservation of inhaled nanoparticle formulations in the lungs. Designing and creating smart nanoformulations to optimize lung deposition, minimize pulmonary clearance, and improve cancerous tissue targeting have been the subject of recent research studies. This review focuses on recent examples of work in this area, along with the opportunities and challenges for the pulmonary delivery of smart nanoformulations to treat lung cancers.

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Radio-sensitization efficacy of gold nanoparticles in inhalational nanomedicine and the adverse effect of nano-detachment due to coating inactivation

Cited by 13 publications

References 41 publications

Radiosensitizing effect of gold nanoparticle loaded with small interfering RNA-SP1 on lung cancer

Radiosensitizing effect of gold nanoparticle loaded with small interfering RNA-SP1 on lung cancer

Application of nano-radiosensitizers in non-small cell lung cancer

Surface-engineered smart nanocarrier-based inhalation formulations for targeted lung cancer chemotherapy: a review of current practices

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