When the content of 90Sr and 137Cs in reservoir water is below the permissible level, even for drinking water, the specific activity of radionuclides in fish can be hundreds and thousands of times higher than the established hygienic standards of DR-2006. The purpose of this work was to determine the maximum permissible concentrations of 90Sr and 137Cs in the water of reservoirs depending on the content of calcium and potassium in the water based on the parameters of the metabolism of cesium and strontium in fish, which guarantee that the established hygienic standards of radionuclides in fish (DR-2006) are not exceeded with a probability of 95%. It is shown that in reservoirs with low water mineralization, the maximum allowable concentrations of 90Sr and 137Cs will be too low at the level of Bq units per cubic meter and difficult to measure, unlike radioactive contamination of fish, which makes them, even with minor radioactive contamination of reservoirs, a unique bioindicator for the purposes radiation protection of people and the environment.