Radioactive iodine (131I) effects on male fertility

Ceccarelli, Claudia; Canale, Domenico; Vitti, Paolo

doi:10.1097/mou.0b013e32831367b3

Cited by 17 publications

(9 citation statements)

References 25 publications

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“…Early menopause has been reported, with median time of menopause of 49.5 years of age in women treated with RAI compared with a control cohort of women with goiters aged 50.0 years (P < .001). 55 The risk of early menopause was not associated with age at initial or repeat RAI therapy, the dose of RAI, or number of doses. The clinical significance of this observation is uncertain.…”

Section: Nasolacrimal Symptomsmentioning

confidence: 88%

“…However, studies suggest no long-term alteration occurs in female fertility. [51][52][53][54][55] Among 2673 pregnancies, Garci et al 56 found no increase in miscarriage within the first year after up to 100 mCi of 131 I. In addition, no differences were seen in stillborns, preterm births, low birth weight, congenital malformations, or death during the first year of life.…”

Section: Nasolacrimal Symptomsmentioning

confidence: 99%

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Complications of Radioactive Iodine Treatment of Thyroid Carcinoma

Lee

2010

J Natl Compr Canc Netw

114

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Radioactive iodine (RAI) in the form of (131)I has been used to treat thyroid cancer since 1946. RAI is used after thyroidectomy to ablate the residual normal thyroid remnant, as adjuvant therapy, and to treat thyroid cancer metastases. Although the benefits of using RAI in low-risk patients with thyroid cancer are debated, it is frequently used in most patients with thyroid cancer and is clearly associated with acute and long-term risks and side effects. Acute risks associated with RAI therapy include nausea and vomiting, ageusia (loss of taste), salivary gland swelling, and pain. Longer-term complications include recurrent sialoadenitis associated with xerostomia, mouth pain, dental caries, pulmonary fibrosis, nasolacrimal outflow obstruction, and second primary malignancies. This article summarizes the common complications of RAI and methods to prevent and manage these complications.

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Section: Nasolacrimal Symptomsmentioning

confidence: 88%

Section: Nasolacrimal Symptomsmentioning

confidence: 99%

Complications of Radioactive Iodine Treatment of Thyroid Carcinoma

Lee

2010

J Natl Compr Canc Netw

114

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“…The degeneration observed in the seminiferous cells and the reduction detected in sperm motility are evidence of toxicity (Khaki, Heidari, Novin, & Khaki, ). Changes in FSH levels are a major marker of germinal epithelium damage (Ceccarelli, Canale, & Vitti, ). Reduced sperm count and motility are reported to be valid markers of male infertility in laboratory animals.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of melatonin on sperm quality in rat after radioiodine treatment

et al. 2018

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This study was designed to investigate the potential radioprotective impact of melatonin on the testicular tissue and sperm quality in rat given radioactive iodine (RAI) therapy. Thirty-six male Wistar albino rats were randomly divided into three groups as untreated control (Group 1); oral radioiodine group (RAI, 111 MBq, administrated rats); and RAI+melatonin group (oral radioiodine and intraperitoneal 12 mg/kg/day melatonin, starting 2 days before and continuing for 1 week after oral RAI administration). Twenty-four hours after the injection of the last melatonin dose, blood samples were taken for hormone analyses and the determination of the total antioxidant capacity. Sperm samples taken from the cauda epididymis were examined for spermatological parameters. Tissue samples taken from the rat testes were stained by TUNEL assay and with haematoxylin-eosin to detect apoptosis and histological alterations. It was demonstrated a significant decrease in epididymal spermatozoa viability and motility in all of the treatment groups, in comparison with the control group (p < .001). A significant decrease was also detected in sperm DNA fragmentation, follicle-stimulating hormone (FSH) level and the index of apoptotic germ cells in the RAI+melatonin group when compared to the radioiodine group. It was concluded that melatonin prevents the adverse affects of RAI on apoptosis and spermatozoa quality.

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“…When an impairment of fertility potential is already present, the option of freezing semen should be considered. Ceccarelli C et al stated that iodine therapy in hyperthyroidism does not cause a worsening of semen analysis but an amelioration in affected patients [28]. …”

Section: Radioactive Iodinementioning

confidence: 99%

Hyperthyroidism

Sharma

Aronow²,

Patel³

et al. 2011

Med Sci Monit

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SummaryHyperthyroidism is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormone. The most common cause of this syndrome is Graves’ disease, followed by toxic multinodular goitre, and solitary hyperfunctioning nodules. Autoimmune postpartum and subacute thyroiditis, tumors that secrete thyrotropin, and drug-induced thyroid dysfunction, are also important causes.

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Radioactive iodine (131I) effects on male fertility

Cited by 17 publications

References 25 publications

Complications of Radioactive Iodine Treatment of Thyroid Carcinoma

Complications of Radioactive Iodine Treatment of Thyroid Carcinoma

The protective effect of melatonin on sperm quality in rat after radioiodine treatment

Hyperthyroidism

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