Radioactive Iodine in the Lymph Leaving the Thyroid Gland

Daniel, P. M.; Gale, Muriel M.; Pratt, O. E.

doi:10.1113/expphysiol.1963.sp001644

Cited by 14 publications

(9 citation statements)

References 6 publications

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“…In addition, thyroglobulin, the protein secreted by follicular cells as part of the thyroid hormone synthesis pathway, also appears selectively in lymph but not venous blood originating from the thyroid gland (233, 234, 553). These findings suggest that the lymphatics represent an additional reservoir for thyroid hormone circulation, however it is worth noting that the release of thyroid hormones into the blood is still considered of primary importance for endocrine function due to the much higher flow rate through blood vessels (232). …”

Section: Organization and Anatomy Of The Lymphatic Systemmentioning

confidence: 99%

Lymphatic Vessel Network Structure and Physiology

Breslin

Yang

Scallan

et al. 2018

Comprehensive Physiology

274

258

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The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease.

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Section: Organization and Anatomy Of The Lymphatic Systemmentioning

confidence: 99%

Lymphatic Vessel Network Structure and Physiology

Breslin

Yang

Scallan

et al. 2018

Comprehensive Physiology

274

258

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“…Examples are thyroid hormones [6] and pressor agents [ 16]. It is reasonable to suppose that lymph arising in the gut, which forms the largest endocrine gland of the body, would also contain some of the regulatory peptides, which are pro duced by endocrine cells scattered through out its mucosa.…”

Section: Introductionmentioning

confidence: 99%

Lymph, Pancreatic and Gastrointestinal Hormones in Response to Feeding in the Conscious Pig

Manolas¹,

Adrian

Dunlop³

et al. 1985

Eur Surg Res

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Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal. Lymph concentrations of the pancreatic hormones insulin, glucagon and pancreatic polypeptide were small compared with plasma concentrations, although postprandial increments were significant. In contrast lymph concentrations of gastrin, cholecystokinin, motilin and gastric inhibitory peptide (GIP) from the foregut showed a more marked postprandial rise than the pancreatic hormones. Indeed the total integrated responses of these peptides in lymph reached about 50% of those seen in arterial plasma. It would appear unlikely that the lymphatics constitute an important transport mechanism for these regulatory peptides. However, lymph concentrations of hormones may reflect levels in interstitial fluid better than plasma and may be of value in assessing putative physiological actions within a target tissue.

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“…DISCUSSION We have not been able to find in the literature any records of studies on undiluted thyroid lymph. The few brief notes which we have found on diluted thyroid lymph are mentioned in our earlier paper on the thyroid lymph of sheep, cats and rabbits (Daniel, Gale & Pratt, 1963).…”

Section: Resultsmentioning

confidence: 99%

“…During work on the lymphatic system of the thyroid gland, collections of undiluted thyroid lymph were made directly from lymphatic vessels draining the thyroid glands of cats, sheep and rabbits which had previously been given 131I (Daniel, Excell, Gale & Pratt, 1962a;Daniel, Gale & Pratt, 1963). This thyroid lymph was found to contain, consistently, high concentrations of radioactive organic iodine which were of the order of a hundred times greater than those found in the thyroid venous or peripheral blood.…”

mentioning

confidence: 99%