Radioactive Isotopes for Radiosynoviorthesis

Coya‐Viña, J.; Marin‐Ferrer, M.; Martin‐Curto, L.M.

doi:10.1002/9780470986929.ch11

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Up until that point 90 Y had also been used in application to elbows and ankles. The radioactive isotope intra-articular injection technique is similar to that used for the aspiration of joint fluid (arthrocentesis) [7].…”

Section: Methodsmentioning

confidence: 99%

What patient, joint and isotope characteristics influence the response to radiosynovectomy in patients with haemophilia?

2011

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The literature describes radiosynovectomy (RS) as a good non-surgical option for reducing synovial membrane size and thus the number of haemarthrosis episodes. However, there are still many aspects concerning the beneficial effects of RS that have not been quantified. A total of 156 radiosynovectomies (RS) were performed in 104 joints corresponding to 78 haemophiliacs (yttrium-90, rhenium-186). The mean patient age was 18 years. In another study involving the same group of patients, the parameters that improved most after RS were pain and haemarthrosis, followed by the World Federation of Hemophilia clinical score, muscle strength and range of movement (ROM). Following RS, improvement was seen to be independent of patient age, haemophilia type and grade, previous haematological treatment, the presence or absence of circulating inhibitor, synovial membrane size, the type of joint (elbow, knee and ankle), previous physical activity or lack of activity, the prior presence or absence of radiographic signs of joint degeneration (arthropathy) or the isotope used. RS is effective in treating haemophilic synovitis and may require 1-3 injections (RS-1, RS-2 and RS-3) spaced 6 months apart. Following RS-1, the knee had a 3.4- and 3.2-fold greater risk of not improving in terms of pain, compared with the elbow and ankle, respectively. Regarding ROM, lesser improvement was recorded after RS-1 in cases of severe haemophilia and the ankle. In other words, severe haemophilia implies a 2.1-fold greater risk of no improvement in ROM compared with mild and moderate haemophilia. In addition, the ankle presented a 6-fold greater risk of not improving in terms of ROM compared with the elbow and knee. RS affords effective treatment of chronic haemophilic synovitis. RS is effective in all patient groups, independently of the presence of circulating inhibitor antibody, the type of joint involved, the degree of synovial membrane hypertrophy and the presence of radiographic findings of joint degeneration (arthropathy).

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Section: Methodsmentioning

confidence: 99%

What patient, joint and isotope characteristics influence the response to radiosynovectomy in patients with haemophilia?

2011

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“…There have been several methods tried to image the intra-articular distribution of radionuclide as well as visualising any associated leakage. Coya-Viña et al proposed using metastable Technetium-99 (99mTc) in conjunction with the 90Y and 186Re injection and tried to show the distribution of the injected isotope indirectly by capturing the images of gamma-emitting isotope (19) . Twenty-four-hour urine collections were obtained to monitor any possible extraarticular leakage but this procedure was left since there was not any detectable radioactivity in urine (11) .…”

Section: Discussionmentioning

confidence: 99%

Comparison of SPECT/CT and Planar Imaging Following Radiosynovectomy

Özülker¹,

Adaş²,

Tatoğlu³

et al. 2016

Okmeydani Medical Journal

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Objective: We aimed to compare the efficacies of SPECT/ CT and planar imaging of joints after radiosynovectomy. Material and Methods: Six patients with hemophylic arthropathy (HA) (5 hemophilia A, 1 hemophilia B) with a mean age 10.5 (range between 8-15) underwent radiosynovectomy in our clinic between January 2004-December 2012. Postradiosynovectomy planar and SPECT-CT imaging of 5 knee joints, 1 elbow joint and two ankle joints were obtained. Results: Distribution pattern of activity showed no difference between SPECT/CT and planar imaging methods. In one patient there was loculation of activity in suprapatellar recess detected with SPECT/CT which was not deliniated in planar image. Conclusion: Addition of SPECT/CT to the postradiosynovectomy imaging protocol might help in identification of those who are at risk for potentially serious local complications.

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“…(1 mm) e muito curta (0,3 mm), nomeadamente soluções coloidais de citrato de 186 Re (rénio) e de 169 Er (érbio), respectivamente [15].…”

Section: Metalofármacosunclassified

Iões Metálicos em Medicina: Do Diagnóstico à Terapia

Santos¹

2014

BSPQuimica

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Assim como a natureza usa metais em sistemas biológicos, também os químicos se aliaram à Medicina na descoberta de medicamentos cujo mecanismo de acção está associado a uma interacção (coordenação) com iões metálicos, de que resultou a Química Inorgânica Medicinal. As suas aplicações dividem-se em duas classes principais: a dos fármacos como compostos orgânicos (ligandos) cuja acção resulta da sua coordenação com iões metálicos existentes no organismo, não ligados ou ligados a proteínas; a dos fármacos como complexos de metais (metalofármacos), cuja resposta clínica depende intrinsecamente do metal, e que são usados na terapia ou no diagnóstico de doenças. Serão aqui apresentados exemplos representativos destas duas classes de fármacos em uso clínico, seguido de uma referência genérica às suas propriedades mais relevantes. Por fim apresenta-se uma selecção de exemplos de resultados recentes em desenvolvimento.

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Radioactive Isotopes for Radiosynoviorthesis

Cited by 6 publications

References 23 publications

What patient, joint and isotope characteristics influence the response to radiosynovectomy in patients with haemophilia?

What patient, joint and isotope characteristics influence the response to radiosynovectomy in patients with haemophilia?

Comparison of SPECT/CT and Planar Imaging Following Radiosynovectomy

Iões Metálicos em Medicina: Do Diagnóstico à Terapia

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