Radioactive Seed Localization Breast Biopsy and Lumpectomy: Can Specimen Radiographs Be Eliminated?

Cox, Charles E.; Furman, Ben; Stowell, Nicholas; Ebert, Mark; Clark, John D.; Dupont, Elizabeth; Shons, Alan R.; Berman, Claudia G.; Beauchamp, John; Gardner, Mary; Hersch, Marla; Venugopal, Priya; Szabunio, Margaret M.; Cressman, Joanne; Diaz, Nils M.; Vrcel, Vesna; Fairclough, Rita

doi:10.1245/aso.2003.03.050

Cited by 59 publications

(46 citation statements)

References 9 publications

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“…In other trial, Cox employed I 125 seeds as a tracer [19]. Titanium seeds were inoculated within the center of the lesion, placed for 5 days followed by excisional biopsy in the operating room.…”

Section: Discussionmentioning

confidence: 99%

Radioguided occult lesion localization (ROLL) versus wire‐guided lumpectomy for non‐palpable breast lesions: A randomized prospective evaluation

Medina‐Franco

Abarca‐Pérez

García-Álvarez

et al. 2008

Journal of Surgical Oncology

128

102

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Section: Discussionmentioning

confidence: 99%

Radioguided occult lesion localization (ROLL) versus wire‐guided lumpectomy for non‐palpable breast lesions: A randomized prospective evaluation

Medina‐Franco

Abarca‐Pérez

García-Álvarez

et al. 2008

Journal of Surgical Oncology

128

102

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“…20 Bracketing with radioactive seeds has been reported to be of value for nonpalpable breast tumors such as invasive ductal/lobular carcinoma, ductal carcinoma in situ, and papillary carcinoma. 4,5,7 Evidently, the here-reported multimodal seeds can potentially be used in previously reported applications for RSL. An advantage of marker seeds and guidewires over ROLL is that the first two do not suffer from tracer spillage and migration.…”

Section: 5mentioning

confidence: 61%

“…Radioactive seed localization ͑RSL͒ provides an alternative radio guidance method to ROLL using titanium marker seeds filled with a small amount of radioactive iodine ͑ 125 I͒. [4][5][6][7] Image-guided localization is typically carried out using x-ray imaging ͓such as ͑stereotactic͒ mammography ͑XM͔͒, ultrasonography ͑US͒, or magnetic resonance imaging ͑MRI͒. 4,[6][7][8] Although WL, ROLL, and RSL all aid in the localization of cancer during surgery, accurate marker placement remains crucial.…”

Section: Introductionmentioning

confidence: 99%

Tumor bracketing and safety margin estimation using multimodal marker seeds: a proof of concept

et al. 2010

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Abstract. Accurate tumor excision is crucial in the locoregional treatment of cancer, and for this purpose, surgeons often rely on guide wires or radioactive markers for guidance toward the lesion. Further improvement may be obtained by adding optical guidance to currently used methods, in the form of intra-operative fluorescence imaging. To achieve such a multimodal approach, we have generated markers that can be used in a pre-, intra-, and post-operative setting, based on a cocktail of a dual-emissive inorganic dye, lipids, and pertechnetate. Phantom experiments demonstrate that these seeds can be placed accurately around a surrogate tumor using ultrasound. Three-dimensional bracketing provides delineation of the entire lesion. Combined with the multimodal nature, this provides the opportunity to predetermine the resection margins by validating the placement accuracy using multiple imaging modalities ͑namely, x ray, MRI, SPECT/CT, and ultrasound͒. The dual-emissive fluorescent properties of the dye provide the unique opportunity to intra-operatively estimate the depth of the seed in the tissue via multispectral imaging: emission green max = 520 nmഛ 5 mm penetration versus emission red max = 660 nmഛ 12 mm penetration. By using particles with different colors, the original geographic orientation of the excised tissue can be determined.

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“…The long half-life of the radioactive seed, iodine 125, allows for RSL placement before neoadjuvant chemotherapy. The cost of the procedure was reported to be comparable to that of WGL, 136 especially if a large volume of cases is performed. 137,138 In the RSL procedure, the radioactive seed is introduced with an 18-gauge needle during standard ultrasound or mammographic exam.…”

Section: Evolving Technologies With Implications Formentioning

confidence: 99%

New Developments in Breast Cancer and Their Impact on Daily Practice in Pathology

Li¹,

Oprea‐Ilies²,

Krishnamurti

2017

Archives of Pathology &Amp; Laboratory Medicine

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Advances in research have transformed our understanding of breast cancers and have altered the daily practice of pathology. Theranostic evaluations performed by pathologists are now critical in triaging the patients into appropriate treatment groups, as are new guidelines that were recently established for the evaluation of HER2/neu gene amplification. Emerging molecular classifications of breast cancers bring novel perspectives to the assessment of individual cases, and opportunities for better treatments. Molecular studies have particularly shed light on distinct biological subsets of triple-negative breast cancers, for which new targeted therapies are being developed. The prognostic and therapeutic utility of new histopathologic parameters, such as tumor-infiltrating lymphocytes, are also being elucidated, and new protocols have been devised for the pathologic evaluation of breast specimens that have undergone neoadjuvant treatment. Novel clinical practices, such as radioactive seed localization, also affect the way breast specimens are processed and evaluated. In this brief review, we highlight the developments that are most relevant to pathology and are changing or could potentially impact our daily practice.

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Radioactive Seed Localization Breast Biopsy and Lumpectomy: Can Specimen Radiographs Be Eliminated?

Cited by 59 publications

References 9 publications

Radioguided occult lesion localization (ROLL) versus wire‐guided lumpectomy for non‐palpable breast lesions: A randomized prospective evaluation

Radioguided occult lesion localization (ROLL) versus wire‐guided lumpectomy for non‐palpable breast lesions: A randomized prospective evaluation

Tumor bracketing and safety margin estimation using multimodal marker seeds: a proof of concept

New Developments in Breast Cancer and Their Impact on Daily Practice in Pathology

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