Concepts in Biochemical Pharmacology 1971
DOI: 10.1007/978-3-642-65177-9_4
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Radioactive Techniques: The Use of Labeled Drugs

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“…Throughout the 1950s the availability of 14 C for medical research from the US Atomic Energy Commission Oak Ridge, Tennessee reactor resulted in an increase in incorporation of 14 C into biological molecules as well as xenobiotics (Maickel et al, 1971;Lappin, 2015). An early example of the use of 14 C in an ADME study in humans can be found in the study of the metabolism of [ 14 C]salicylic acid (Alpen et al, 1951).…”
Section: The Origins Of Human Adme Studiesmentioning
confidence: 99%
“…Throughout the 1950s the availability of 14 C for medical research from the US Atomic Energy Commission Oak Ridge, Tennessee reactor resulted in an increase in incorporation of 14 C into biological molecules as well as xenobiotics (Maickel et al, 1971;Lappin, 2015). An early example of the use of 14 C in an ADME study in humans can be found in the study of the metabolism of [ 14 C]salicylic acid (Alpen et al, 1951).…”
Section: The Origins Of Human Adme Studiesmentioning
confidence: 99%