Radiobiological Advanced Biostack Experiment

Bücker, H.; Horneck, G.; Facius, R.; Reitz, Günther; Schäfer, M.; Schott, J. U.; Beaujean, R.; Enge, W.; Schopper, E.; Heinrich, H.C.; Beer, Jürg; Wiegel, B.; Pfohl, R.; François, H.; Portal, G.; Bonting, S.L.; Graul, E.H.; Rüther, W.; Kranz, A.R.; Bork, Ulrich; Koller-Lampert, K.; Kirchheim, B.; Starke, M.; Planel, H; Delpoux, M.

doi:10.1126/science.225.4658.222

Cited by 28 publications

(5 citation statements)

References 2 publications

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“…One solution to this problem is to send payloads to destinations outside Earth's magnetosphere. An example of this is the pair of Biostack experiments that were carried into lunar orbit on the NASA Apollo 16 and 17 missions (Horneck et al, 1974;Bü cker et al, 1984). Another solution is to launch a satellite into a highinclination orbit that includes frequent, typically brief, excursions into comparatively weak regions of Earth's magnetic field as it passes over the north and south magnetic poles or the South Atlantic Anomaly.…”

Section: Introductionmentioning

confidence: 98%

The O/OREOS Mission: First Science Data from the Space Environment Survivability of Living Organisms (SESLO) Payload

et al. 2011

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We report the first telemetered spaceflight science results from the orbiting Space Environment Survivability of Living Organisms (SESLO) experiment, executed by one of the two 10 cm cube-format payloads aboard the 5.5 kg Organism/Organic Exposure to Orbital Stresses (O/OREOS) free-flying nanosatellite. The O/OREOS spacecraft was launched successfully to a 72° inclination, 650 km Earth orbit on 19 November 2010. This satellite provides access to the radiation environment of space in relatively weak regions of Earth's protective magnetosphere as it passes close to the north and south magnetic poles; the total dose rate is about 15 times that in the orbit of the International Space Station. The SESLO experiment measures the long-term survival, germination, and growth responses, including metabolic activity, of Bacillus subtilis spores exposed to the microgravity, ionizing radiation, and heavy-ion bombardment of its high-inclination orbit. Six microwells containing wild-type (168) and six more containing radiation-sensitive mutant (WN1087) strains of dried B. subtilis spores were rehydrated with nutrient medium after 14 days in space to allow the spores to germinate and grow. Similarly, the same distribution of organisms in a different set of microwells was rehydrated with nutrient medium after 97 days in space. The nutrient medium included the redox dye Alamar blue, which changes color in response to cellular metabolic activity. Three-color transmitted intensity measurements of all microwells were telemetered to Earth within days of each of the 48 h growth experiments. We report here on the evaluation and interpretation of these spaceflight data in comparison to delayed-synchronous laboratory ground control experiments.

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Section: Introductionmentioning

confidence: 98%

The O/OREOS Mission: First Science Data from the Space Environment Survivability of Living Organisms (SESLO) Payload

et al. 2011

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“…These experiments were continued in LEO using the Free Flyer Biostack Experiment (LDEF-Long Duration Exposure Facility) [142], EURECA-European Retrievable Carrier [143][144][145][146], and the biosatellites COSMOS 1887 and 2004 [147,148] and refined, so that synergistic effects of HZE particle hits and microgravity in the developmental disorders of C. morosus were revealed.…”

Section: Biomolecular Changes Induced By Space Radiationmentioning

confidence: 99%

Space Radiobiology

Hellweg,

Arena,

Baatout

et al. 2023

Radiobiology Textbook

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The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field.After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure.The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.

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“…Spätere Ballonflüge bis zu einer Höhe von 41 Kilometern wiesen mikroskopische Formen (Kokken und Stäbchen) auf den gekühlten Probensammlern nach; allerdings konnten nur zwei Zellen der Stämme Bacillus simplex und Staphylococcus pasteuri [3] kultiviert werden. [4]. Hierbei wechseln Lagen von Kernspurdetektoren (Emulsionen und Plastikfolien) mit biologischen Lagen (Pflanzensamen, Insekteneiern und Bakteriensporen) (Abb.…”

Section: Obere Grenze Der Biosphäreunclassified

“…1). Nach dem Weltraumflug und der Entwicklung der physikalischen Detektoren werden die beobachteten biologischen Effekte mit den Strahlungsdaten korreliert [4]. Für die mikroskopisch kleinen Sporen von Bacillus subtilis gelang es mithilfe von Mikromethoden, die Sporeninaktivierung in Abhängigkeit von ihrer Entfernung von der Teilchenspur zu bestimmen (Abb.…”

Section: Obere Grenze Der Biosphäreunclassified

Mikroben im All — Aufgaben für die Mikrobiologie

Horneck

Möller

2011

Biospektrum

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Radiobiological Advanced Biostack Experiment

Cited by 28 publications

References 2 publications

The O/OREOS Mission: First Science Data from the Space Environment Survivability of Living Organisms (SESLO) Payload

The O/OREOS Mission: First Science Data from the Space Environment Survivability of Living Organisms (SESLO) Payload

Space Radiobiology

Mikroben im All — Aufgaben für die Mikrobiologie

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