2016
DOI: 10.1667/rr14266.1
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Radiobiological Effectiveness of Ultrashort Laser-Driven Electron Bunches: Micronucleus Frequency, Telomere Shortening and Cell Viability

Abstract: Laser-driven electron accelerators are capable of producing high-energy electron bunches in shorter distances than conventional radiofrequency accelerators. To date, our knowledge of the radiobiological effects in cells exposed to electrons using a laser-plasma accelerator is still very limited. In this study, we compared the dose-response curves for micronucleus (MN) frequency and telomere length in peripheral blood lymphocytes exposed to laser-driven electron pulse and X-ray radiations. Additionally, we eval… Show more

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Cited by 26 publications
(26 citation statements)
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“…Laser‐plasma accelerators produce femtosecond electron bunches that are quasi mono‐energetic with energies in the range of tens of MeV up to a few GeV, and with a pulsed dose‐rate exceeding 10 13 Gy/s. Results have been recently reported on biological material irradiated with laser generated electrons both in vitro and in vivo. …”
Section: High Dose‐rate Radiation Sourcesmentioning
confidence: 99%
See 1 more Smart Citation
“…Laser‐plasma accelerators produce femtosecond electron bunches that are quasi mono‐energetic with energies in the range of tens of MeV up to a few GeV, and with a pulsed dose‐rate exceeding 10 13 Gy/s. Results have been recently reported on biological material irradiated with laser generated electrons both in vitro and in vivo. …”
Section: High Dose‐rate Radiation Sourcesmentioning
confidence: 99%
“…Laser-plasma accelerators produce femtosecond electron bunches 51 that are quasi mono-energetic with energies in the range of tens of MeV up to a few GeV, and with a pulsed dose-rate exceeding 10 13 Gy/s. Results have been recently reported on biological material irradiated with laser generated electrons both in vitro 52,53 and in vivo. 54,55 In order to destroy tumor cells that adapt to radiation, synergy between the effects of subsequent pulses or different types of radiation is taken into consideration in complex radiotherapy-oriented studies.…”
Section: B Beyond Laser-generated Protons: Heavy Ions and Other Tymentioning
confidence: 99%
“…Recent achievements in the field of particle acceleration technologies has led to development of cost- and size-effective laser-driven electron accelerators (LDEAs) [11, 12]. This technology permits to deliver high energy beams (from few MeV up to several hundred MeV) into deep layers of tissue in pico- or femtosecond durations with little lateral spread [1315].…”
Section: Introductionmentioning
confidence: 99%
“…Studies of the genetic effects of accelerated particles are still limited. Recently genetic effects of irradiation with LDEA were estimated using comet assay [29, 30], micronucleus test [12] and gammaH2AX foci, reflecting level of DSBs [16, 31, 32]. But for all we know, the effect of accelerated particles on CNVs has not yet been studied.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the extremely short duration of LPA bunches allows possible novel phenomena in radiobiology to be investigated, possibly gaining access to the very early phase of the damage induced on a particular cell structure by the primary ionizing particle 58 . Several works have been reported in the field over the past decade 50,59,60 .…”
mentioning
confidence: 99%