Radiochemical analysis :

DeVoe, James R.

doi:10.6028/nbs.tn.404

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…20 The more intense components of the v2 and v3 bands in Figure 1 are presumably transitions to these levels. A similar conclusion has been reached by Lever and (25), 7145 (42), 19,050 sh, w 14,705 (470), 15,015 sh, 15,750 (400), 10,000 (13) 17,390 (305), 18,050 17,390 (185), 10,100 (15) 18,020 sh, 18,725 sh, w Co(MQN)(NCS)2-C2H5OH Acetone 6370 (10), 8200 (35), 15,450 (450), 16,025 sh, 17,860 (150), 490 630 10,700 (20) 18,520 sh a Abbreviations: w, weak; sh, shoulder. Molar extinction coefficients are given in parentheses.…”

Section: Resultsmentioning

confidence: 99%

Transition metal chemistry of quinuclidinone-containing ligands. II. Spectral and megnetic properties of some transition metal complexes containing 2(N-morpholinylmethyl)-3-quinuclidinone and related ligands

Dickinson¹,

Long²

1974

Inorg. Chem.

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Complexes of cobalt(II), nickel(II), and iron(II) halides with the title compound were prepared by adding the appropriate metal salt to the ligand in alcoholic solutions. The complexes have pseudotetrahedral microsymmetry around the central metal ion as indicated by their spectral and magnetic properties; the coordination sphere contains one bidentate nitrogenbonded ligand and two halide atoms. Ligand field band assignments, metal-halide stretching frequencies, and magnetic susceptibility data are given for each of the complexes. The cobalt(II) and nickel(II) perchlorate complexes of the title compound were also prepared, and each contains two bidentate ligands which provide a tetrahedral ligand field that is stronger than for the halide complexes. It is suggested that the apparent preference of the ligand for one-to-one metal-toligand coordination and the consequent tetrahedral structures result from a combination of the size of the quinuclidine group and the rigidity of the five-membered chelate ring formed by the coordinated ligand. In addition to these pseudotetrahedral complexes, an octahedral nickel chloride complex which apparently contains bridging chloride ligands is reported. A cobaltous thiocyanate complex is also found to have an octahedral structure in the solid state and a tetrahedral structure in solution.(7) B.

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Section: Resultsmentioning

confidence: 99%

Transition metal chemistry of quinuclidinone-containing ligands. II. Spectral and megnetic properties of some transition metal complexes containing 2(N-morpholinylmethyl)-3-quinuclidinone and related ligands

Dickinson¹,

Long²

1974

Inorg. Chem.

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“…For proteomic samples, two main ionization principles have been developed, electrospray ionization (ESI) and matrix assisted laser desorption ionization (MALDI), the first being commonly used for interfacing sample separation platforms to MS instrumentation (e.g., HPLC or capillary electrophoresis-CE [2][3][4][5] ), while the second for enabling, MS detection from samples prepared in a microarray format. 6 Microchip devices that enable fluidic manipulations integrate additional functional elements for fluid delivery, sample cleanup and preconcentration, derivatization, and separation. 7,8 The development of microfluidic chips with MS detection has been captured over the years in numerous review articles that describe in detail both functional components and operational characteristics.…”

Section: Microfluidic Chips and Mass Spectrometry Detectionmentioning

confidence: 99%

“…13 For MALDI-MS from a chip, the MS interface designs evolved from simple deposition on a target plate to progressively more complex and challenging rotating-ball interfaces and piezo-actuated flow-through dispensers, and ultimately to centrifugal CDs that encompass multiple functional elements. 6 Performing liquid phase separations on these devices is, however, possible only after dispensing the sample on a target, with the caveat that separation efficiency may be lost. Overall, the development of ESI vs MALDI chip-MS ion sources has dominated the field, mainly due to the power of tandem MS in elucidating the structure of unknown compounds, a capability that works at its best with ESI-MS. Work on improving the chip-MS interfaces and the sample ionization process has continued over the years, resulting in novel strategies that use surface acoustic wave nebulizers, 14 electro-sonic flow focusing ionization, 15 voltage-assisted liquid desorption, 16 or multichannel configurations for simultaneous electrospraying and sample extraction.…”

Section: Microfluidic Chips and Mass Spectrometry Detectionmentioning

confidence: 99%

Protein and Proteome Measurements with Microfluidic Chips

2019

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Major scientific discoveries in the last two decades have been enabled by the development of high-throughput sequencing and mass spectrometry (MS) technologies. Omics analysis, at the genome, transcriptome, proteome, or metabolome levels, has paved the way for the elucidation of many molecular mechanisms that underlie disease, biomarker and drug-target discovery, and diagnostics and precision medicine applications. With the realization that the biological interpretation of results generated from biological tissues or cell-derived samples is highly impacted by cell heterogeneity, many efforts have been redirected toward the omics characterization of single cells. As miniaturized devices represent ideal platforms for the analysis of small sample amounts, omics analysis has found a flourishing ground in the microfluidics instrumentation development arena. This Review aims at capturing the latest protein and proteome analysis technologies that have been developed and implemented on microfluidic platforms, with a focus on developments that have been documented in the past two years. Emphasis was placed on challenging aspects that relate to sensitivity and handling sample complexity, as well as on applications that address demanding biological and biomedical problems.

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Radiochemical analysis :

Cited by 2 publications

References 12 publications

Transition metal chemistry of quinuclidinone-containing ligands. II. Spectral and megnetic properties of some transition metal complexes containing 2(N-morpholinylmethyl)-3-quinuclidinone and related ligands

Transition metal chemistry of quinuclidinone-containing ligands. II. Spectral and megnetic properties of some transition metal complexes containing 2(N-morpholinylmethyl)-3-quinuclidinone and related ligands

Protein and Proteome Measurements with Microfluidic Chips

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