A 53-year-old man presented to our dermatology clinic with a painful, firm, well-defined indurated plaque (26 × 18 cm) on the mid-back, including a sclerodermiform and crusty central area (5 × 4 cm), which he had first noticed 8 months previously (Figure 1A). Ten months before presentation, he received a diagnosis of hepato car cinoma, which was treated with arterial chemoembol ization, requiring multiple prolonged fluoroscopy sessions. Based on his history and presentation, we suspected radiation dermatitis; differential diagnoses included squamous cell carcinoma, morphea and panniculitic lymph oma. We biopsied the lesion, and pathological analysis showed dermal sclerosis, red blood cell extravasation with hemosiderin pigment and reactive endothelium without vasculitis. The history of radiation exposure, clinical presentation and histology confirmed the diagnosis of radiation dermatitis.An ulcer developed in the centre of the lesion 2 months after presentation. Despite starting treatment with topical betamethasone and mupirocin, and negative pressure dressings, the lesion progressed in size (Figure 1B). The patient had resection and reconstruction with a myocutaneous flap (Figure 1C). Further histo pathology confirmed the previous biopsy findings.Radiation dermatitis is classified as either acute (in the first 90 days after radiation) or chronic (months to years after radiation). The total radiation dose is the most important causal factor. 1 The diagnosis is primarily clinical and should be considered in any patient with a history of procedures using fluoroscopy who develops well-defined skin lesions; however, biopsy is essential to rule out malignant disease. 2 For radiation dermatitis without ulceration, topical treatments can be effective. Once an ulcer appears, reconstructive surgery is usually ne cessary to allow wound healing. Case reports show no difference in reconstructive outcomes with fasciocutaneous flaps compared with full-thickness skin grafts. Resolution depends on adequate resection of the damaged areas beyond the sclerotic plaque. 3