Radiofrequency ablation of liver tumours: systematic review

Decadt, B.; Siriwardena, Ajith K.

doi:10.1016/s1470-2045(04)01567-0

Cited by 170 publications

(88 citation statements)

References 67 publications

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“…With ablation therapy, tumor cell death is achieved via chemical (percutaneous ethanol injection), cold-based (cryotherapy), or heat-based (radiofrequency ablation (RFA), microwave coagulation therapy (MCT), or laser hyperthermia techniques. Thermal ablation therapy is widely used, and the safety and efficacy of this technique have been well characterized [3,4]. Cryotherapy has also gained acceptance as a local ablative treatment [5,6].…”

Section: Introductionmentioning

confidence: 99%

Serum cytokine levels in response to hepatic cryoablation

Osada

Imai

Tomita

et al. 2007

Journal of Surgical Oncology

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Section: Introductionmentioning

confidence: 99%

Serum cytokine levels in response to hepatic cryoablation

Osada

Imai

Tomita

et al. 2007

Journal of Surgical Oncology

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“…In recent years, image-guided percutaneous tumour ablation using radiofrequency (RF) energy has become increasingly popular and has gained wide acceptance as a valuable, minimally invasive treatment for primary and secondary liver malignancies [1]. Compared with conventional surgery, RF ablation (RFA) has many advantages in terms of reduced complications, morbidity and mortality as well as its cost-effectiveness.…”

mentioning

confidence: 99%

Multiple-electrode radiofrequency ablations using Octopus® electrodes in anin vivoporcine liver model

Lee²,

Ws³

et al. 2012

BJR

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Objectives: The objective of this study was to determine the in vivo efficacy of radiofrequency ablation (RFA) in porcine liver using Octopus j electrodes for creating a large coagulation compared with RFA using clustered electrodes. Methods: A total of 39 coagulations were created using a 200-W generator and clustered electrodes or Octopus electrodes during laparotomy in 19 pigs. Radiofrequency was applied to the livers using four protocols: (1) Group A-1, monopolar mode using a clustered electrode (n511); (2) Group A-2, monopolar mode using an Octopus electrode (n511); (3) Group B-1, consecutive monopolar mode using three, clustered electrodes (n58); and (4) Group B-2, switching monopolar mode using two Octopus electrodes (n59). The energy efficiency, shape, diameters (D) and volume (V) of the coagulation volume were compared in each of the two groups. Results: The mean maximum D and V of the coagulations in Group A-2 (4.7 cm and 33.1 cm 3 , respectively) were significantly larger than those in Group A-1 (4.1 cm and 20.3 cm 3 , respectively) (p,0.05). Furthermore, the mean minimum D, maximum D and V of the coagulations in Group B-2 were significantly larger than those in Group B-1, i.e. 5.3 vs 4.0 cm, 6.6 vs 4.9 cm and 66.9 vs 30.2 cm 3 , respectively (p,0.05). The energy efficiencies were also significantly higher in Groups A-2 and B-2 than in Groups A-1 and B-1 (p,0.05). Conclusion: The Octopus electrodes were more efficient for creating a large ablation zone than clustered electrodes, and the efficacy of RFA with Octopus electrodes can be amplified in the switching monopolar mode.

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“…However in the same study, surgery was more efficient than RFA for the subset of HCCs ranging from 31 to 50 mm: one and 3-year survival rates were reported at 92% and 68% in the surgical group vs. 81% and 42% in the RFA group (P = .03). [30][31][32][33][34][35][36] Unfortunately, significant number of patients with uninodular small size HCC cannot be treated by these potential curative options due to patient characteristics or tumour topography. Furthermore only a limited number of those patients can benefit of liver transplantation.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of transarterial chemoembolization combined to conformal radiotherapy for uninodular hepatocellular carcinoma

Merle

Rode

Benlaredj

et al. 2014

Int J Cancer Ther Oncol

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Original ArticleAbstract Purpose: A proportion of patients with uninodular hepatocellular carcinoma (HCC) cannot benefit from potential curative therapies such as liver transplantation, surgical resection or radiofrequency ablation. Thus, they are prone to receive transarterial chemoembolization (TACE) that is a palliative option with low probability of both complete response and prolonged local control. Herein, we assessed the combination of TACE and 3D-high dose conformal radiotherapy (3D-HDCRT) for efficacy and safety in HCC. Methods: We retrospectively analyzed the outcome of 35 consecutive patients with uninodular HCC ≤ 100 mm, treated by one course of TACE combined to 3D-HDCRT. The follow-up consisted on clinics, biology, hepatic CT-scan or MRI at month-1 and -3, and thereafter every 3 months. Results: Complete response was obtained in 80% of patients following mRE-CIST criteria (95% in HCC ≤ 50 mm, and 60% in HCC > 50 mm) with uncommon local recurrence (11%), overall survival rates of 79%, 59% and 44% at respectively 1, 2 and 3 years (median, 37.3 months), and 11.4% grade-3/4 toxicities. Pre-therapeutic α-fetoprotein level ≥ 200 ng/mL was found as a strong predictor of poorer outcome. Conclusion: We showed that TACE combined to 3D-HDCRT can be highly efficient to reach local control and interesting overall survival rates for uninodular HCC, with limited severe toxicities for Child-Pugh A patients. Subsequent prospective controlled trials are warranted for comparison with therapeutic standards.

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Radiofrequency ablation of liver tumours: systematic review

Cited by 170 publications

References 67 publications

Serum cytokine levels in response to hepatic cryoablation

Serum cytokine levels in response to hepatic cryoablation

Multiple-electrode radiofrequency ablations using Octopus® electrodes in anin vivoporcine liver model

Efficacy and safety of transarterial chemoembolization combined to conformal radiotherapy for uninodular hepatocellular carcinoma

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