Radiofrequency Ablation of Renal Tumors Improved by Preoperative ex-Vivo Computer Simulation Model

Abstract

This experimental model allows successful planning of the expected necrotic region using RFA in a cadaver kidney. Future planning can be improved by using a perfused in-vivo kidney model, thus allowing much more precise computer simulation before applying RFA to kidney tumors at critical locations.

A thermoelastic deformation model of tissue contraction during thermal ablation

“…For a safe clinical implementation of such techniques, it is important to accurately determine the volume of ablated tissue. Pre-procedural planning, such as experimental data and computer simulation tools, can provide such information and thus aid in determining the optimal patient specific treatment [1][2][3].…”

“…Studies have attempted to develop a computational framework to predict the performance of different ablation devices and procedures for clinical implementation [1][2][3], characterised from ex vivo and in vivo animal studies [4,5]. These models, however, have not considered the effects of tissue contraction during hyperthermic ablation therapies, which can be observed on immediate post-procedural images both in clinical and experimental settings [6,7].…”

Tissue Contraction Caused by Radiofrequency and Microwave Ablation: A Laboratory Study in Liver and Lung

“…The expected size and shape of an ablation zone created by a given device is often based upon these experimental results and utilized to predict clinical performance during human application. Characterization data also aides in pre-procedural planning, potentially in conjunction with computer modeling and treatment planning software (17, 18). As a result, knowledge of the volume of tissue that a device can successfully ablate is important for optimal and safe clinical implementation.…”

Numerical Analysis of Renal Artery Pathologies

“…1. Артериальная сеть почки делирование процессов повреждения почек при их травме и определение свойств тканей почек [1][2][3][4]; моделирование оперативного вмешательства на почках (микроволновая хирургия, дистанционная литотрипсия) [5][6][7][8][9]; моделирование уродинамики мочеточника и мочевого пузыря [10][11][12]…”