Radiofrequency Ablation of the Liver

Huang, Liping; Dodd, Gerald D.; Lanctot, Anthony C.

doi:10.1016/j.acra.2012.04.004

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…The RFA time for solid tumors is usually 12 to 15 min. When a monopolar electrode is used, the ablation scope in vivo is approximately a 3 cm diameter sphere;while in vitro , it can reach a diameter sphere of nearly 4 cm due to absence of blood flow [2]. Tumor patients eligible for RFA may have received various metal implants such as stents, silver clips, titanium clips, or 125 I seeds left over after the surgery, which are often adjacent to important blood vessels, bile ducts, or intestines, raising concerns about thermal damage [3,4], and urging experimental data for assessment.…”

Section: Discussionmentioning

confidence: 99%

An in-vitro animal experiment on metal implants’ thermal effect on radiofrequency ablation

Zhao

Chu

et al. 2013

World J Surg Onc

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BackgroundTo explore metal implants’ thermal effect on radiofrequency ablation (RFA) and ascertain distance-thermal relationship between the metal implants and radiofrequency (RF) electrode.MethodsMetal implants models were established in seven in-vitro porcine livers using silver clips or 125I seeds. RFA were conducted centering the RF electrode axis1 cm away from them, with one side containing a metal implants model the test group and the other side the control group. The thermometric needles were used to measure multi-point temperatures in order to compare the time-distance-temperature difference between the two groups. The gross scopes of the ablation of the two groups were measured and the tissues were analyzed for microscopic histology.ResultsAt the ablation times of 8, 12, and 15 min, the average multi-point temperatures of the test group and the control group were 48.2±18.07°C, 51.5±19.57°C, 54.6±19.75°C, and 48.6±17.69°C, 52.2±19.73°C, 54.9±19.24°C, respectively, and the differences were not statistically significant (n=126, P>0.05). At the ablation times of 12 and 15 min, the ablation scopes of the test group and the control group were (horizontal/longitudinal diameter) 1.55/3.48 cm, 1.89/3.72 cm, and 1.56/3.48 cm, 1.89/3.72 cm, respectively, and the differences were not statistically significant (n=14, P>0.05). The two groups had the same manifestations in microscopy.ConclusionsMetal implants do not cause significant thermal effect on RFA.

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Section: Discussionmentioning

confidence: 99%

An in-vitro animal experiment on metal implants’ thermal effect on radiofrequency ablation

Zhao

Chu

et al. 2013

World J Surg Onc

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“…We tested the null hypotheses that (1) there is no association between gross ablation zone volume and VFI, (2) there is no association between gross ablation zone volume and FI and (3) there is no association between gross ablation zone volume and VI. To test those hypotheses, we performed a backward stepwise regression on all three of the candidate predictor variables with a Type I error rate of 0.05.…”

Section: Statistical Analysis Methodsmentioning

confidence: 99%

“…However, the RF ablation zone volume is markedly variable, 1 which is predominantly due to variable hepatic perfusion. 2 The variability in RF ablation zone volume demonstrates an inverse correlation with local hepatic blood flow owing to heat sink effect. That is, the greater the local hepatic blood flow, the smaller the ablation zone.…”

mentioning

confidence: 99%

“…That is, the greater the local hepatic blood flow, the smaller the ablation zone. 2 Based on the inverse relationship between flow and ablation size, the ability to measure local hepatic blood flow contemporaneously with an ablation procedure should enable the prediction of the size of ablation that will be obtained with an RF ablation device. There are several three-dimensional (3D) volumetric colour Doppler vascular indices developed to quantify blood flow, among which vascularization index (VI), flow index (FI) and vascularization flow index (VFI) are the ones most commonly used.…”

mentioning

confidence: 99%

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The prediction of radiofrequency ablation zone volume using vascular indices of 3-dimensional volumetric colour Doppler ultrasound in an in vitro blood-perfused bovine liver model

Chang¹,

Lanctot²,

McCarter³

et al. 2017

The British Journal of Radiology

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Although FI was associated with ablation zone volumes, it could not sufficiently explain their variability, limiting its clinical applicability. VI, FI and VFI are not clinically useful in the prediction of RF ablation zone volume in the liver. Advances in knowledge: Despite a significant association of FI with ablation zone volumes, VI, FI and VFI cannot be used for their prediction. Different Doppler vascular indices need to be investigated for clinical use.

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What is the difference in ablation zone of multi-bipolar radiofrequency ablation between liver cirrhosis and normal liver background? – a prospective clinical study

Hong

Lee

Cao

et al. 2020

International Journal of Hyperthermia

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Radiofrequency Ablation of the Liver

Cited by 3 publications

References 33 publications

An in-vitro animal experiment on metal implants’ thermal effect on radiofrequency ablation

An in-vitro animal experiment on metal implants’ thermal effect on radiofrequency ablation

The prediction of radiofrequency ablation zone volume using vascular indices of 3-dimensional volumetric colour Doppler ultrasound in an in vitro blood-perfused bovine liver model

What is the difference in ablation zone of multi-bipolar radiofrequency ablation between liver cirrhosis and normal liver background? – a prospective clinical study

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