Radiofrequency Ablation of Thyroid Nodules: A Long-Term Prospective Study of 24 Patients

Martínez, Jesús Aldea; Viana, Laura Aldea; Martínez, José Luis López; Pérez, Enrique Ruiz

doi:10.1016/j.jvir.2019.04.022

Cited by 25 publications

(18 citation statements)

References 25 publications

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“…Table 1 shows the detailed characteristics of the 12 studies, including five on RFA [ 10 – 14 ] and seven on LA [ 3 – 9 ]. Two studies (one RFA and one LA study) were multicenter designs [ 8 , 12 ], but the others were from single centers.…”

Section: Resultsmentioning

confidence: 99%

“…All studies commonly included nodules verified as being benign by tissue confirmation; however, the detailed inclusion and exclusion criteria were similar but slightly different across the studies. Nine studies included symptomatic or cosmetic problems in the inclusion criteria [ 3 , 4 , 6 , 7 , 9 , 10 , 12 – 14 ], whereas the other three did not mention the presence of such problems [ 5 , 8 , 11 ]. Only one study involved the treatment of toxic or hot nodules [ 5 ].…”

Section: Resultsmentioning

confidence: 99%

“…One of five studies in the RFA group [ 11 ] and four of seven studies in the LA group performed a single ablation session for the nodules [ 4 , 5 , 8 , 9 ]. However, three of five studies in the RFA group [ 10 , 12 , 13 ], and three of seven studies in the LA group performed either a single or multiple sessions of ablation [ 3 , 6 , 7 ]. The mean number of ablation sessions ranged from one to 3.5 in the RFA group, and one to 1.2 in the LA group.…”

Section: Resultsmentioning

confidence: 99%

“…In the LA group, one study performed ablation without local anesthesia or sedation [ 5 ], one study used sedation without local anesthesia [ 4 ], two studies used local anesthesia without sedation [ 3 , 8 ], and the other three studies used both local anesthesia and sedation [ 6 , 7 , 9 ]. In terms of techniques, the studies in the RFA group commonly used a trans-isthmic approach and a moving-shot technique [ 10 – 14 ], while the studies in the LA group commonly used pull-back techniques [ 3 – 9 ].…”

Section: Resultsmentioning

confidence: 99%

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Long-Term Results of Thermal Ablation of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Ultrasound-guided thermal ablations have become one of the main options for treating benign thyroid nodules. To determine efficacy of thermal ablation of benign thyroid nodules, we performed a meta-analysis of studies with long-term follow-up of more than 3 years. Methods: Databases were searched for studies published up to August 25, 2019, reporting patients with benign thyroid nodules treated with thermal ablation and with follow-up data of more than 3 years. Data extraction and quality assessment were performed according to PRISMA guidelines. The analysis yielded serial volume reduction rates (VRRs) of ablated nodules for up to 3 years or more, and adverse effect of ablation during follow-up. Radiofrequency ablation (RFA) and laser ablation (LA) were compared in a subgroup analysis. Results: The pooled VRRs for ablated nodules showed rapid volume reduction before 12 months, a plateau from 12 to 36 months, and more volume reduction appearing after 36 months, demonstrating long-term maintenance of treatment efficacy. Thermal ablation had an acceptable complication rate of 3.8%. Moreover, patients undergoing nodule ablation showed no unexpected delayed complications during the follow-up period. In the subgroup analysis, RFA was shown to be superior to LA in terms of the pooled VRR and the number of patients who underwent delayed surgery. Conclusion: Thermal ablations are safe and effective methods for treating benign thyroid nodules, as shown by a long follow-up analysis of more than 3 years. In addition, RFA showed superior VRRs compared with LA for the treatment of benign thyroid nodules, with less regrowth and less delayed surgery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Long-Term Results of Thermal Ablation of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

et al. 2020

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“…The management of thyroid nodules is based on the nodule function, local compression symptoms, cosmetic complaints, patient anxiety, and the possibility of malignancy [9][10][11]. Studies have shown that even thyroid solid nodules diagnosed as a benign lesion in FNA still had a 6% likelihood of being diagnosed as a malignant lesion in surgical pathology [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Ethanol Injection, Radiofrequency Ablation, and Levothyroxine Therapy in the Management of Benign Thyroid Nodules

Arefzadeh

Avankai

Abrishami

et al. 2020

Preprint

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Background: Thyroid nodules are a common clinical finding. Even though there are various accepted treatments for the benign thyroid nodules, there are alternative methods for managing these patients with fewer expenses and also minimum complications. This study aims to compare the volume decline of radiofrequency (RF) ablation and single-session ethanol ablation (EA) and the effects of levothyroxine therapy for benign thyroid nodule treatment.Materials: In this clinical trial, 90 patients with benign thyroid nodules in different centers in Tehran, Iran, from December 6, 2018, to December 6, 2019, were included. Patients who had met the inclusion criteria were selected and randomly allocated into three groups (each of 30) of a single session of radiofrequency ablation (Group 1), a single session of ethanol injection (Group 2), or a 6-month LT4 treatment (Group 3). Thyroid tests, including TSH, T4, T3, anti-TPO, T3RU, and serum Calcitonin level, were recorded at baseline and again at 1, 3, and six months. Nodule volume was also assessed through sonography at baseline and the other checkpoints.Results: The mean volume reduction after 6 months of intervention for ethanol injection group, radiofrequency ablation group, and LT4 treatment group were 72.2%, 83.4%, and 21.8%, respectively. There was a significant relationship between mean volume reduction and months (1, 3, and six) (P<0.001).Conclusions: Although radiofrequency ablation therapy is the best modality for managing benign thyroid nodules in our study, it is more expensive than the other modalities despite comparable therapeutic effects.

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RFA and benign thyroid nodules: Review of the current literature

Muhammad

Santhanam

Russell

et al. 2021

Laryngoscope Investig Oto

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Benign thyroid nodules (BTNs) are commonly found in the general population. They are usually asymptomatic and their incidence has increased as a result of wide‐spread use of ultrasound. Benign nodules are typically monitored clinically until they increase in size, resulting in compressive symptoms warranting surgery. However, although surgery is generally well‐tolerated and of low‐risk, it is associated with a small risk for several complications including hypothyroidism, nerve injury, hematoma, injury to other structures and wound infection. Recently, newer image‐guided ablation techniques including radiofrequency ablation (RFA) have been introduced. RFA has a similar safety profile when compared to surgery and has shown promising results in challenging surgical candidates. Though several studies have been published in Asian and European countries on the efficacy of RFA, limited data is available on the North American population. The aim of the study is to review the current literature establishing the clinical outcomes and safety of RFA for benign nodules. Level of evidence V.

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Radiofrequency Ablation of Thyroid Nodules: A Long-Term Prospective Study of 24 Patients

Cited by 25 publications

References 25 publications

Long-Term Results of Thermal Ablation of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

Long-Term Results of Thermal Ablation of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

Evaluation of Ethanol Injection, Radiofrequency Ablation, and Levothyroxine Therapy in the Management of Benign Thyroid Nodules

RFA and benign thyroid nodules: Review of the current literature

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