Radiofrequency ablation with four electrodes as a building block for matrix radiofrequency ablation: Ex vivo liver experiments and finite element method modelling. Influence of electric and activation mode on coagulation size and geometry

Mulier, Stefaan; Possebon, Ricardo; Jiang, Yansheng; Jamart, Jacques; Chong, Wang; Miao, Yi; Yu, Tong-Fu; Jiang, Kuirong; Feng, Yuanbo; Marchal, Guy; Michel, Luc; Ni, Yicheng

doi:10.1016/j.suronc.2020.02.005

Cited by 7 publications

(4 citation statements)

References 147 publications

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“…Although the liver is commonly used for the assessment of the distribution and efficacy of ablative therapies [48][49][50][51][52][53][54][55][56], we plan to expand this work in the future to include other healthy tissues as well as cancerous lesions. Future studies should elucidate the effect of tissue biophysical differences (i.e., vascularity, stiffness, density).…”

Section: Discussionmentioning

confidence: 99%

“…While the swine liver differs from the human liver in external morphology, it has a similar size, segmental anatomy, vascularity, and biliary tree structure [47]. The efficacy of ablative therapies is commonly examined and in healthy liver tissue [48][49][50][51][52][53][54][55][56] specifically, traditional ethanol ablation [32,48,57] (PEI), radiofrequency ablation [54,58] (RFA), microwave ablation [55,[59][60][61] (MWA), drug-eluting bead embolization [62], and high-intensity focused ultrasound [63] (HIFU) are used. These relatively homogeneous tissues provide a consistent environment for such studies.…”

Section: Assessment Of Distribution Volume Of Ece In Ex Vivo and In V...mentioning

confidence: 99%

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Determining the Relationship between Delivery Parameters and Ablation Distribution for Novel Gel Ethanol Percutaneous Therapy in Ex Vivo Swine Liver

Chelales,

von Windheim,

Banipal

et al. 2024

Polymers

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Ethyl cellulose–ethanol (ECE) is emerging as a promising formulation for ablative injections, with more controllable injection distributions than those from traditional liquid ethanol. This study evaluates the influence of salient injection parameters on forces needed for infusion, depot volume, retention, and shape in a large animal model relevant to human applications. Experiments were conducted to investigate how infusion volume (0.5 mL to 2.5 mL), ECE concentration (6% or 12%), needle gauge (22 G or 27 G), and infusion rate (10 mL/h) impacted the force of infusion into air using a load cell. These parameters, with the addition of manual infusion, were investigated to elucidate their influence on depot volume, retention, and shape (aspect ratio), measured using CT imaging, in an ex vivo swine liver model. Force during injection increased significantly for 12% compared to 6% ECE and for 27 G needles compared to 22 G. Force variability increased with higher ECE concentration and smaller needle diameter. As infusion volume increased, 12% ECE achieved superior depot volume compared to 6% ECE. For all infusion volumes, 12% ECE achieved superior retention compared to 6% ECE. Needle gauge and infusion rate had little influence on the observed depot volume or retention; however, the smaller needles resulted in higher variability in depot shape for 12% ECE. These results help us understand the multivariate nature of injection performance, informing injection protocol designs for ablations using gel ethanol and infusion, with volumes relevant to human applications.

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Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Distribution Volume Of Ece In Ex Vivo and In V...mentioning

confidence: 99%

Determining the Relationship between Delivery Parameters and Ablation Distribution for Novel Gel Ethanol Percutaneous Therapy in Ex Vivo Swine Liver

Chelales,

von Windheim,

Banipal

et al. 2024

Polymers

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“…The clinician manipulates the internal structures through small incisions to make the treatment region accessible and to ensure that the treatment is performed on the right location. LLA has four different types: Radiofrequency Ablation (RFA) [32][33][34]48 , Microwave Ablation (MWA) [48][49][50][51] , Irreversible Electroporation (IRE) 52 , Cryoablation (CA) [53][54][55] and Ethanol Injection (EI) [56][57][58] Modeling strategies. To establish a generic process model of MILT, the modeling strategies proposed in our previous work 10 were applied as described below.…”

Section: Methodsmentioning

confidence: 99%

Generic surgical process model for minimally invasive liver treatment methods

Gholinejad

Pelanis

Edwin

et al. 2022

Sci Rep

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Surgical process modelling is an innovative approach that aims to simplify the challenges involved in improving surgeries through quantitative analysis of a well-established model of surgical activities. In this paper, surgical process model strategies are applied for the analysis of different Minimally Invasive Liver Treatments (MILTs), including ablation and surgical resection of the liver lesions. Moreover, a generic surgical process model for these differences in MILTs is introduced. The generic surgical process model was established at three different granularity levels. The generic process model, encompassing thirteen phases, was verified against videos of MILT procedures and interviews with surgeons. The established model covers all the surgical and interventional activities and the connections between them and provides a foundation for extensive quantitative analysis and simulations of MILT procedures for improving computer-assisted surgery systems, surgeon training and evaluation, surgeon guidance and planning systems and evaluation of new technologies.

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“…While on the other side, the authors simulated FEM to ablate breast cancer by using RFA and succeeded in abating 80% of the tumor [18]. In [19], the authors designed FEM to ablate liver tumors by using cool-tip RF electrodes.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Thermal and Electrical Conductivities on the Ablation Volume during Radiofrequency Ablation Process

Ahmed¹,

El-Wakad²,

Hassan³

2023

IJACSA

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Radiofrequency ablation (RFA) is the treatment of choice for certain types of cancers, especially liver cancer. However, the main issue with RFA is that the larger the tumor volume, the longer the ablation period. That causes more pain for the patient, so the surgeons perform a larger number of ablation sessions or surgeries. The current commonly used electrode material, nickel-titanium alloy, used in RFA is characterized by low thermal and electrical conductivities. Using an electrode material with higher electrical conductivity and thermal conductivity provides more thermal energy to tumors. In this paper, we design two models: a cool-tip RF electrode and a multihook RF electrode, which aim to study the effect of the thermal and electrical conductivities of the electrode material on ablation volume. Gold, silver, and platinum have higher thermal and electrical conductivity than nickel and titanium alloy, and therefore we studied the effect of these materials on the ablation volume using two different designs, which are the RF cooling tip electrode and the multi-hook electrode. The proposed model reduces the ablation time and damages healthy tissue while increasing the ablation volume with values ranging from 2.6 cm 3 to 15.4 cm 3 . The results show ablation volume increasing with materials characterized by higher thermal and electrical conductivities and thus reducing patient pain.

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Radiofrequency ablation with four electrodes as a building block for matrix radiofrequency ablation: Ex vivo liver experiments and finite element method modelling. Influence of electric and activation mode on coagulation size and geometry

Cited by 7 publications

References 147 publications

Determining the Relationship between Delivery Parameters and Ablation Distribution for Novel Gel Ethanol Percutaneous Therapy in Ex Vivo Swine Liver

Determining the Relationship between Delivery Parameters and Ablation Distribution for Novel Gel Ethanol Percutaneous Therapy in Ex Vivo Swine Liver

Generic surgical process model for minimally invasive liver treatment methods

The Effect of Thermal and Electrical Conductivities on the Ablation Volume during Radiofrequency Ablation Process

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