Radiofrequency Balloon Angioplasty Rationale and Proof of Principle

Becker, Gary J.; Lee, B I; Waller, Bruce F.; Barry, Kevin J.; Kaplan, Jonathan; Connolly, Raymond J.; Dreesen, R. Gerald; Nardella, Paul C.

doi:10.1097/00004424-198811000-00002

Cited by 34 publications

(16 citation statements)

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“…The 180-sec total time of treatment is empiric and consistent with the typical clinical practice of two to three balloon inflations each for 60 to 90 sec. The mechanism of heat assisted angioplasty accounting for the sealing of vascular disruptions is thought to be the thermal fusion of separated tissue layers in the media and adventitia [ 12,15,16]. Denaturation of collagen occurring at or near 63°C could result in altered vascular wall properties accounting for the sealing of the vascular disruption [ 161.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, laser balloon angioplasty operating at a tissue temperature of 90-1 10°C appears to be an effective modality for vessel salvage following abrupt closure after PTCA [8-1 I]. Other less expensive methods of heating angioplasty balloons such as microwave [ 141 and radiofrequency [15][16][17][18] have recently been developed and are undergoing animal and clinical investigation.…”

Section: Introductionmentioning

confidence: 99%

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Endoluminal sealing of vascular wall disruptions with radiofrequency‐heated balloon angioplasty

Resar

Wolff

Hruban

et al. 1993

Cathet. Cardiovasc. Diagn.

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Suboptimal luminal widening or acute closure secondary to arterial dissection remain significant risks of percutaneous transluminal balloon angioplasty. Non surgical techniques are often employed in an attempt to repair dissections either as temporary or definitive treatment. The aim of this study was to test the hypothesis that radiofrequency thermal balloon angioplasty at an operating temperature of 70 degrees C and low inflation pressure could seal dissections and perforations in a model of severe arterial wall damage. Dissections and perforations were created in renal (n = 4) and carotid (n = 4) arteries in four mongrel dogs. Endoluminal sealing was then attempted with conventional balloon angioplasty or radiofrequency thermal balloon angioplasty (2 atm at 70 degrees C). Contrast dye extravasation persisted in all cases following conventional balloon angioplasty but completely resolved with radiofrequency balloon angioplasty in all but one artery. Histologic examination of the arteries treated with radiofrequency balloon angioplasty showed extensive thermal injury, including transmural coagulation necrosis, flattening of the internal elastic lamina, and medial thinning. On the basis of these results, the utility of thermal balloon angioplasty for endoluminal sealing of dissections and perforations complicating angioplasty deserves further evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endoluminal sealing of vascular wall disruptions with radiofrequency‐heated balloon angioplasty

Resar

Wolff

Hruban

et al. 1993

Cathet. Cardiovasc. Diagn.

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“…Radiofrequency thermal balloon angioplasty was introduced as a new technique for percutaneous arterial dilatation in the 1990's [54][55][56] , yet due to increased restenosis rates observed in patients receiving this therapy 57 , it was soon abandoned as a percutaneous interventional treatment option. Using this system, Staab et al 58 and our laboratory 39 have investigated a porcine heat-injury restenosis model.…”

Section: Porcine Heat-injury Restenosis Modelmentioning

confidence: 99%

Importância dos estudos pré-clínicos em animais de experimentação para a cardiologia intervencionista

Suzuki¹,

Yeung²,

Ikeno³

2008

Arq. Bras. Cardiol.

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“…The chronic restenosis was prevented compared to the conventional balloon angioplasty [8,10] because (i) the arterial dilatation with PTDBA was performed without vascular injuries and (ii) a part of the smooth muscle cells in the media was died by short-term heating. The concept of thermal angioplasty, dilating the arteries without the vascular injuries by vascular heating, had been already proposed in late 1980s by Spears et al [11] and Becker et al [12]. Although these thermal angioplasties had very good outcomes on acute phase, the chronic restenosis rate was almost 100 % because of the thermal damages to the adventitia [13,14].…”

Section: Introductionmentioning

confidence: 99%

Basic study of effects on the smooth muscle cells' proliferation with novel short-term thermal angioplasty in vitro and in vivo

et al. 2011

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We investigated the effect on smooth muscle cells' proliferation with stretch-fixing in both in vitro and in vivo porcine study to determine the optimum heat condition of novel short-term thermal angioplasty, Photo-thermo Dynamic Balloon Angioplasty (PTDBA). With PTDBA, we have obtained the sufficient arterial dilatation by short-term heating (< 15 s, < 70 °C) and low dilatation pressure (< 0.4 MPa) without excessive neo-intimal hyperplasia on chronic phase. The smooth muscle cells were found to be fixed with stretched shape in vascular wall after PTDBA in vivo. The deformation rate of smooth muscle cells' nuclei was 1.6 ± 0.1 after PTDBA (15 s, 65 °C, 0.35 MPa). The smooth muscle cells, which were extracted from porcine arteries, were cultured on the specially designed equipment to give stretch-fixing stimulus in vitro. The cell proliferation was inhibited at 20 % stretching compared to 15 % stretching significantly (p < 0.05). The immunostaining specimens of basic Fibroblast Growth Factor (bFGF) and its receptor FGFR-1 were made from the porcine arteries in vivo. We found that the expressions of bFGF and FGFR-1 in the media were not observed after PTDBA. We think that these results suggested the possibility for the inhibition of the excessive cell proliferation after PTDBA.

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Radiofrequency Balloon Angioplasty Rationale and Proof of Principle

Cited by 34 publications

References 0 publications

Endoluminal sealing of vascular wall disruptions with radiofrequency‐heated balloon angioplasty

Endoluminal sealing of vascular wall disruptions with radiofrequency‐heated balloon angioplasty

Importância dos estudos pré-clínicos em animais de experimentação para a cardiologia intervencionista

Basic study of effects on the smooth muscle cells' proliferation with novel short-term thermal angioplasty in vitro and in vivo

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