Radiofrequency irradiation attenuates angiogenesis and inflammation in UVB‐induced rosacea in mouse skin

Son, Myeongjoo; Park, Joonhong; Oh, Seyeon; Choi, Junwon; Shim, Minjung; Kang, Donghwan; Byun, Kyunghee

doi:10.1111/exd.14115

Cited by 17 publications

(17 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In that study, follicular ablation and selective photothermolysis were apparent; these destroyed the telangiectasia and induced remodeling of dermal collagen [ 104 ]. In one study, radiofrequency irradiation improved rosacea induced by ultraviolet B in an animal model by reducing keratinocyte proliferation; it also improved the levels of pro-inflammatory cytokines, angiogenesis-related inflammatory factors, and VEGF, and attenuated the VEGF-induced pathophysiology of rosacea, reducing tube formation, cell migration, and endothelial cell proliferation [ 105 ].…”

Section: Rosaceamentioning

confidence: 99%

Angiogenesis in Chronic Inflammatory Skin Disorders

Lee

Hong

Kim

2021

IJMS

104

View full text Add to dashboard Cite

Angiogenesis, the growth of new blood vessels from preexisting vessels, is associated with inflammation in various pathological conditions. Well-known angiogenetic factors include vascular endothelial growth factor (VEGF), angiopoietins, platelet-derived growth factor, transforming growth factor-β, and basic fibroblast growth factor. Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) have recently been added to an important angiogenic factor. Accumulating evidence indicates associations between angiogenesis and chronic inflammatory skin diseases. Angiogenesis is deeply involved in the pathogenesis of psoriasis. VEGF, angiopoietins, tumor necrosis factor-a, interleukin-8, and interleukin-17 are unregulated in psoriasis and induce angiogenesis. Angiogenesis may be involved in the pathogenesis of atopic dermatitis, and in particular, mast cells are a major source of VEGF expression. Angiogenesis is an essential process in rosacea, which is induced by LL-37 from a signal cascade by microorganisms, VEGF, and MMP-3 from mast cells. In addition, angiogenesis by increased VEGF has been reported in chronic urticaria and hidradenitis suppurativa. The finding that VEGF is expressed in inflammatory skin lesions indicates that inhibition of angiogenesis is a useful strategy for treatment of chronic, inflammatory skin disorders.

show abstract

Section: Rosaceamentioning

confidence: 99%

Angiogenesis in Chronic Inflammatory Skin Disorders

Lee

Hong

Kim

2021

IJMS

104

View full text Add to dashboard Cite

show abstract

“…In the frequency range used in this exploratory study, radiofrequency may have other, possibly non-thermal effects of more prominence in lichen-like chronic inflammatory conditions-reduced keratinocyte proliferation and decreased expressions of TGFβ, NF-κB, IL-8, other pro-inflammatory cytokines and chemokines, and angiogenesisrelated inflammatory factors. These other effects are most likely the basis of the improvements observed after radiofrequency treatments in rosacea and acne lesions and scars [13,14].…”

Section: Discussionmentioning

confidence: 99%

An exploratory, prospective cohort study of non-invasive dynamic quadripolar radiofrequency energy in vulvar lichen management. The new-generation DQRF™ option

Prestia¹,

Bertozzi²,

Raichi³

2021

Obstet Gnecol Rep

View full text Add to dashboard Cite

Introduction:The main vulvar lichen treatment goal is itch reduction; improving and preserving the skin integrity and texture, healing the fissures and erosions, and preventing the later disfiguring fibrosis are the other crucial treatment goals. The side effect burden of high-potency topical corticosteroids, the current gold standard, can be heavy and alternative options are welcome. The paper illustrates the first exploratory outcomes in vulvar lichen planus and lichen sclerosus by the latest lowenergy technological evolution of radiofrequency treatments, Dynamic Quadripolar RadioFrequency™, in synergistic combination with in-depth penetration of active principles via Ultra-Pulsed Radioporation™.Methods: Explorative cohort study in 58 ambulatory women 27 to 80 years old, eighteen nulliparous and 26 uniparous, 53.4% in the postmenopausal period. The DQRF™ treatment program mainly aimed at symptom control, with four weekly sessions -10 minutes over the lichenified vulvar areas and 10 minutes of vaginal rejuvenation even without evidence of lichen vaginal extension. Assessments (baseline and at the end of the treatment cycle): pain and dyspareunia (10-cm impromptu Visual Analogue Scales), vulvar burning (4-score Likert-like impromptu scale), vulvar lesions (binary evaluation -Yes / No).Results: After a month, vulvar lichen inflammation appeared cooled down, and all cohort women reported dramatic improvements in daily and sexual symptomsvariable between -81.2% and -92% for pain, burning and itching, and -83% for dyspareunia.Conclusions: Control of lichen inflammation, as documented by sequential photographs, is likely the rationale behind the very favourable outcomes after DQRF™ + UPR™ treatment. Well-designed comparative studies are critical to defining the role of the novel radiofrequency technology in vulvar lichen management.

show abstract

“…Highlighting in vivo mouse model studies are recent works on hair follicle development and growth 1‐5 and wound healing 6‐8 . Further, studies in animal models often help to elucidate aspects of disease pathogenesis, and mouse models are used to investigate mechanisms of human skin conditions such as atopic dermatitis, 9‐13 contact dermatitis, 14‐16 psoriasis, 17,18 rosacea 19 and squamous cell carcinoma 20 to name a few.…”

Section: Bridging the Gap Between “Simplicity” Of In Vitro And Complementioning

confidence: 99%

Fostering a healthy culture: Biological relevance of in vitro and ex vivo skin models

Atwood

Plikus

2021

Experimental Dermatology

View full text Add to dashboard Cite

The field of experimental dermatology research has dramatically benefited from the insights yielded by in vivo studies on animal models. Indeed, much of our understanding of the mechanisms that regulate embryonic skin development, adult skin homeostasis and physiological skin responses to stress, such as wound healing, has been educated by studies conducted in animal models, including mutant mice. These works become commonly published on the pages of Experimental Dermatology and, in fact, represent one of the core interests of the journal. Highlighting in vivo mouse model studies are recent works on hair follicle development and growth 1-5 and wound healing. 6-8 Further, studies in animal models often help to elucidate aspects of disease pathogenesis, and mouse models are used to investigate mechanisms of human skin conditions such as atopic dermatitis, 9-13 contact dermatitis, 14-16 psoriasis, 17,18 rosacea 19 and squamous cell carcinoma 20 to name a few. On the other hand, not all human skin diseases or aspects of human skin physiology can be reliably modelled in rodents. This is not surprising, considering that humans and rodents are separated by an estimated 96 million years of evolution. 21 Addressing this fact, many studies are being conducted on patient-derived primary skin cells, including human keratinocytes, 22-25 melanocytes, 26-30 fibroblasts 31-34 and cell co-cultures. 35-37 However, typical in vitro culture conditions fail to replicate and, in fact, do not come close to imitating the biomechanical and biochemical complexity of the microenvironment in which cells exist and to which they respond to in native tissues. Further, ingredients in commonly used cell culture media and the two-dimensional constraints of growth on plastic result in cells being exposed to a lot of artificial cues, to which they adapt but also prominently alter their gene expression profile and functional activities in the process. Therefore, behaviours displayed by skin cells in twodimensional cultures need to be comprehensively validated under more native-like conditions in order to be deemed biologically and physiologically relevant. Helping to bridge the gap, threedimensional (3D) organotypic cultures and organ culture techniques have long been a highly instructive tool for investigating complex, tissue-level behaviours by skin cells.

show abstract

Radiofrequency irradiation attenuates angiogenesis and inflammation in UVB‐induced rosacea in mouse skin

Cited by 17 publications

References 39 publications

Angiogenesis in Chronic Inflammatory Skin Disorders

Angiogenesis in Chronic Inflammatory Skin Disorders

An exploratory, prospective cohort study of non-invasive dynamic quadripolar radiofrequency energy in vulvar lichen management. The new-generation DQRF™ option

Fostering a healthy culture: Biological relevance of in vitro and ex vivo skin models

Contact Info

Product

Resources

About