Introduction: Ewing sarcoma of bone represents the second most common primary malignant tumor of the bone in children and adolescents. The most common primary bony sites include the long bones, pelvis, chest wall, and spine. However, it is responsible for only 3% to 5% of cases in bones of the hands and feet. Case Presentation: The case was a 13-year-old girl, who attended our clinic with a complaint of 8 months of left ankle swelling and pain. Eight months earlier, she recalled an ankle torsion for which treatment was performed with long leg splint. Her pain was better, but, her swelling remained. The X ray showed a sclerotic lesion in the calcaneus with soft-tissue mass. Next, she underwent open biopsy, and was diagnosed with Ewing's sarcoma. She underwent chemoradiotherapy and obtained below knee amputation. She was followed up at our clinic.
Conclusions:There are a few articles about early diagnotic effects of Ewing's sarcoma prognosis. Therefore, this study aimed at presenting an anatomical-rare case of Ewing's sarcoma as preliminary diagnosis could help the patient and lead to better outcomes.