2022
DOI: 10.1177/00236772221124381
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Radiographic assessment of the impact of sex and the circadian rhythm-dependent behaviour on gastrointestinal transit in the rat

Abstract: Relatively little is known about the influence of sex and the circadian rhythm on gastrointestinal transit. However, these factors could have an important impact on aspects such as digestion, oral absorption of drugs or the clinical manifestation of gastrointestinal diseases, among others. Remarkably, preclinical models have scarcely taken these factors into consideration. In this study, we assessed the gastrointestinal transit of young adult Wistar Han rats of both sexes, under normal and inverted light cycle… Show more

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Cited by 6 publications
(15 citation statements)
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“…Interestingly, PCB52 levels showed a sex effect in the intestinal content ( Figure 2 H), likely because of sex differences in physiological parameters, such as the gastrointestinal transit time. 52 Moreover, a significant effect of sex on PCB52 levels was observed in the liver and serum, with higher PCB52 levels in male rats than female rats ( Figure 2 H). Although the estimated PCB52 doses differed significantly by sex ( Figure 1 B), the differences are small and unlikely to explain the sex differences in PCB52 tissue levels.…”
Section: Resultsmentioning
confidence: 92%
See 3 more Smart Citations
“…Interestingly, PCB52 levels showed a sex effect in the intestinal content ( Figure 2 H), likely because of sex differences in physiological parameters, such as the gastrointestinal transit time. 52 Moreover, a significant effect of sex on PCB52 levels was observed in the liver and serum, with higher PCB52 levels in male rats than female rats ( Figure 2 H). Although the estimated PCB52 doses differed significantly by sex ( Figure 1 B), the differences are small and unlikely to explain the sex differences in PCB52 tissue levels.…”
Section: Resultsmentioning
confidence: 92%
“…The lack of a dose effect on PCB52 tissue levels can be attributed to experimental errors in the dose determination, variability of PCB levels between animals, and subtle differences in the time course of PCB52 tissue levels at the low vs high dose. Interestingly, PCB52 levels showed a sex effect in the intestinal content (Figure H), likely because of sex differences in physiological parameters, such as the gastrointestinal transit time . Moreover, a significant effect of sex on PCB52 levels was observed in the liver and serum, with higher PCB52 levels in male rats than female rats (Figure H).…”
Section: Resultsmentioning
confidence: 97%
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“…The alterations in this axis can be the cause of GI functional alterations such as irritable bowel syndrome and contribute to symptoms of inflammatory bowel disease, which includes Crohn’s disease and ulcerative colitis [ 17 , 18 , 19 , 20 ]. Additionally, sex is one of the main factors that affect the cerebral and GI functions and determine the prevalence and severity of the diseases affecting the BGA [ 21 , 22 , 23 , 24 ]. Thus, the study of the BGA functions in both males and females, whether under healthy or pathologic conditions, is extremely important.…”
Section: Introductionmentioning
confidence: 99%