Radiographic findings in acromegaly: pictorial essay

Baptista, Luisa Couto; Martins, Marcelo Mantiolhe; Marcos, Vinícius Neves

doi:10.1590/0100-3984.2022.0083-en

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…23 Enlarged thickened skull bones, prominent frontal sinuses, enlarged mandible, and widened pituitary fossa, its double floor and loss of clinoid processes are the few plain radiographic marks for diagnosis. 24 But owing to the low sensitivity of this test, MRI brain has taken its place as the investigation of choice now. 7,10,15 All four of the reported cases in this study had macro-adenoma on MRI but only two of them had suggestive radiological features on skull radiograph.…”

Section: Resultsmentioning

confidence: 99%

Recognizing the Diverse Clinical Presentations of Acromegaly: Insight from a Case Series

Salam MU,

Jabeen R,

Ahmad MM

et al. 2024

JSWMC

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Purpose: Acromegaly is an endocrine disease due to growth hormone excess with slowly developing manifestations and diverse clinical presentations. There are chances that patients may present with common clinical problems and the underlying endocrine condition is overlooked and diagnosis is delayed. This case series will discuss the presentation, clinical features and investigations of four acromegaly cases to increase the clinical skills of physicians so that an early diagnosis is made and treatment is initiated early. Methods: This is an observational study, where a series of four acromegaly cases, who presented to medicine inpatients or outpatients of Sylhet Women’s Medical College, Bangladesh. They were analyzed through detailed clinical features and, investigation findings. MRI brain was used as the main tool for diagnosis. Serum levels of growth hormone, IGF-1, TSH, ACTH, and prolactin were assessed in all. Other anterior pituitary hormone assays were selectively done. Ocular examinations were performed on all patients. Conclusion: Though a case series has lower value as medical evidence than systematic reviews and randomized clinical trials, it can help in generating future protocols of studies. This series emphasizes that a keen clinical eye of the physician can help in early diagnosis of acromegaly and thus an early MRI of brain based on clinical suspicion can ensure early treatment and prevent cardiovascular complications.

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Section: Resultsmentioning

confidence: 99%

Recognizing the Diverse Clinical Presentations of Acromegaly: Insight from a Case Series

Salam MU,

Jabeen R,

Ahmad MM

et al. 2024

JSWMC

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show abstract

“…Radiographic features include significant thickening of the cranial bones and enlargement of the frontal sinuses. Magnetic Resonance Imaging (MRI) of the pituitary gland is crucial for the diagnosis of acromegaly ( Baptista et al, 2023 ).…”

Section: Endocrine/metabolic Related Craniofacial Deformitiesmentioning

confidence: 99%