Objectives
To examine whether categories of anatomic alignment (varus, neutral,valgus) measured from knee x-rays agree with similar categories of mechanical alignment from the full limb film and whether varus anatomic malalignment predicts medial joint space loss on knee x-rays as well as varus mechanical alignment.
Methods
We used data from the OAI (full limb and flexed knee x-rays) to examine agreement of anatomic and mechanical alignment and data from BOKS to evaluate the association of full limb mechanical alignment vs. knee x-ray anatomic alignment with joint space loss. A four degree offset was used to correct for the more valgus angulation of the anatomic alignment.
Results
Of 143 subjects whose knee x-rays and full limb films were publicly released from the OAI, the agreement of varus, neutral and valgus alignment was only moderate (κ= 0.43, p<.001). In BOKS, varus mechanical and anatomic alignments measured from full limb and knee x-rays respectively both predicted a high risk of medial joint space loss vs. neutral alignment (for mechanical alignment, OR = 4.82 (95% CI 1.93, 12.00) and for anatomic alignment OR = 4.25 (95% CI 2.08,8.72).
Conclusions
While agreement of alignment from knee x-ray to full limb film was only moderate, varus malalignment measured from a flexed knee predicted the likelihood of progression well. Flexed knee alignment may be more relevant to knee OA risk than that of a fully extended knee, but a measurement of alignment from a short limb is an imperfect surrogate for full limb alignment.