Radiographic scoring methods in rheumatoid arthritis and psoriatic arthritis

Salaffi, Fausto; Carotti, Marina; Beci, Giacomo; Carlo, Marco Di; Giovagnoni, Andrea

doi:10.1007/s11547-019-01001-3

Cited by 35 publications

(35 citation statements)

References 59 publications

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“…Semiquantitative analysis was assessed through morphological standard MR sequences using a modified whole-organ magnetic resonance score (WORMS) [27]. This modified score included the evaluation of four articular compartments (medial and lateral femoral condyle, medial and lateral patella) and analysis of the following parameters: cartilage signal intensity and morphology, subchondral bone marrow oedema, subchondral cysts, synovitis/joint effusion [28]. To evaluate cartilage signal intensity and morphology, we used an eight-point scale as follows: 0 = normal thickness and signal intensity; 1 = normal thickness but increased signal intensity on T2-weighted images; 2 = focal and partial-thickness focal defect < 1 cm in greatest width; 2.5 = full-thickness focal defect < 1 cm in greatest width; 3 = multiple areas of partial-thickness (grade 2.0) defects intermixed with areas of normal thickness, or a grade 2.0 defect wider than 1 cm but < 75% of the region; 4 = diffuse (≥ 75% of the region) partial-thickness loss; 5 = multiple areas of full-thickness loss (grade 2.5) or a grade 2.5 lesion wider than 1 cm but < 75% of the region; 6 = diffuse (≥ 75% of the region) full-thickness loss.…”

Section: Morphological Analysismentioning

confidence: 99%

T2-mapping MRI evaluation of patellofemoral cartilage in patients submitted to intra-articular platelet-rich plasma (PRP) injections

et al. 2021

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This study evaluated the ability of T2 mapping magnetic resonance imaging at 3 T, in addition to morphological sequences, to assess efficacy of platelet-rich plasma (PRP) injections, characterizing qualitatively and quantitatively the grade of knee cartilage repair in patients with patellofemoral chondropathy. We retrospectively studied 34 patients (22 men, 12 women, mean age 41.8 years, including 22 men) with patellofemoral knee chondropathy, who underwent intra-articular PRP injections and completed a clinical and instrumental follow-up. As control group, we evaluated 34 patients who underwent non-operative therapy. All patients were submitted to clinical (using VAS and WOMAC index) and imaging studies with 3 T magnetic resonance with cartilage analysis with T2 mapping sequences for cartilage analysis before and after treatment. In the study group, mean pre-treatment T2 relaxation time values were 44.2 ± 2.5 ms, considering all articular cartilage compartments, with significant reduction at the follow-up (p < 0.001). At the index compartment, mean pre-treatment T2 relaxation times values were 47.8 ± 3.6 ms, with statistically significant reduction at the follow-up (p < 0.001). Evaluation of focal cartilage lesions reported pre-treatment mean T2 value of 70.1 ± 13.0 ms and post-treatment mean value of 59.9 ± 4.6 ms (p < 0.001). From a clinical point of view, the pre-treatment WOMAC and VAS scores were 18.3 ± 4.5 and 7 (IQR:6–7.2), respectively; the post-treatment values were 7.3 ± 3.2 and 2 (IQR: 1.7–3.0), respectively (p < 0.001). In the control group, despite clinical improvement, we didn’t find significant T2 values change during the follow-up period. In conclusion, T2 mapping is a valuable indicator for chondropathy and treatment-related changes over time.

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Section: Morphological Analysismentioning

confidence: 99%

T2-mapping MRI evaluation of patellofemoral cartilage in patients submitted to intra-articular platelet-rich plasma (PRP) injections

et al. 2021

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“…Structural joint damage and radiographic progression are reflected by an increased joint space narrowing [ 14 ]. Radiographic progression is described by the change of radiographic scoring between two time points and can be detected by different established scoring techniques [ 15 , 16 ] as well as the computer-aided quantification of finger JSW by CAJSA [ 7 – 9 ].…”

Section: Discussionmentioning

confidence: 99%

Radiographic remission in rheumatoid arthritis quantified by computer-aided joint space analysis (CASJA): a post hoc analysis of the RAPID 1 trial

et al. 2020

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Background The reduction of finger joint space width (JSW) in patients with rheumatoid arthritis (RA) is strongly associated with joint destruction. Treatment with certolizumab pegol (CZP), a PEGylated anti-TNF, has been proven to be effective in RA patients. The computer-aided joint space analysis (CAJSA) provides the semiautomated measurement of joint space width at the metacarpal-phalangeal joints (MCP) based on hand radiographs. The aim of this post hoc analysis of the RAPID 1 trial was to quantify MCP joint space distance (JSD-MCP) measured by CAJSA between baseline and week 52 in RA patients treated with certolizumab pegol (CZP) plus methotrexate (MTX) compared with MTX/placebo. Methods Three hundred twenty-eight patients were included in the post hoc analysis and received placebo plus MTX, CZP 200 mg plus MTX and CZP 400 mg plus MTX. All patients underwent X-rays of the hand at baseline and week 52 as well as assessment of finger joint space narrowing of the MCP using CAJSA (Version 1.3.6; Sectra; Sweden). The joint space width (JSW) was expressed as mean joint space distance of the MCP joints I to V (JSD-MCPtotal). Results The MTX group showed a significant reduction of joint space of − 4.8% (JSD-MCPtotal), whereas in patients treated with CZP 200 mg/MTX and CZP 400 mg/MTX a non-significant change (JSD-MCPtotal + 0.6%) was observed. Over 52 weeks, participants with DAS28 remission (DAS28 ≤ 2.6) exhibited a significant joint space increase of + 3.3% (CZP 200 mg plus MTX) and + 3.9% (CZP pegol 400 mg plus MTX). Conclusion CZP plus MTX did not reduce JSD-MCPtotal estimated by CAJSA compared with MTX/placebo. Furthermore, clinical remission (DAS28 ≤ 2.6) in patients treated with CZP plus MTX was associated with an increasing JSD, indicating radiographic remission in RA.

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“…Эрозивный процесс считается отличительной чертой РА -наблюдается практически у 98% больных [10]. Для оценки прогрессирования заболевания, отражающего кумулятивный ущерб с течением времени, наиболее предпочтительным методом визуализации остается рентгенография [11]. Достоверные рентгенологические изменения рассматриваются как признак необратимого повреждения тканей сустава [10].…”

Section: особенности структурного прогрессированияunclassified

How to Stop the Structural Progression in Ankylosing Spondylitis

Каратеев¹

2019

EPh

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Radiographic scoring methods in rheumatoid arthritis and psoriatic arthritis

Cited by 35 publications

References 59 publications

T2-mapping MRI evaluation of patellofemoral cartilage in patients submitted to intra-articular platelet-rich plasma (PRP) injections

T2-mapping MRI evaluation of patellofemoral cartilage in patients submitted to intra-articular platelet-rich plasma (PRP) injections

Radiographic remission in rheumatoid arthritis quantified by computer-aided joint space analysis (CASJA): a post hoc analysis of the RAPID 1 trial

How to Stop the Structural Progression in Ankylosing Spondylitis

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