Radioiodinated free fatty acids; can we measure myocardial metabolism?

Visser, Frans C.; Eenige, M. J. van; Duwel, C. M. B.; Roos, J. P.

doi:10.1007/bf00258097

Cited by 16 publications

(10 citation statements)

References 13 publications

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“…Rather, the clearance reflects the transfer of free iodide across the cellular membranes [14]. On the other hand, the clearance of carbon-11 determined from the catabolism of 11 C-palmitate does reflect fatty acid metabolism [15].…”

Section: Normal Myocardial Metabolism and Metabolic Imagingmentioning

confidence: 99%

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Myocardial metabolic and receptor imaging in idiopathic dilated cardiomyopathy

et al. 2002

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Idiopathic dilated cardiomyopathy (IDC) is a distinct disease of the myocardium, of unknown etiology. The disease can occur acutely, or evolve in a subacute fashion. IDC is often associated with a substantial impairment of ventricular function, which may recover over time. Although spontaneous recovery of LV function occurs in 20%-45% of newly diagnosed patients, the majority of patients do not do well. IDC has an average 5-year mortality of 20%. Abnormalities of energetics, perfusion, and adrenergic control of the myocardium are markers of the status of LV dysfunction. As the heart fails, changes occur in the production and catabolism of high-energy substrates, the efficiency of mitochondrial oxidative processes, the distribution of resting perfusion and coronary vasodilating capacity and the adrenergic receptor density and function. This article reviews the information provided by metabolic and receptor imaging in patients with IDC, and the role the data may play in patient management.

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Section: Normal Myocardial Metabolism and Metabolic Imagingmentioning

confidence: 99%

“…1, Table 1) [13,14,15] can be extensively and quantitatively determined with PET. Since substrate utilization can change as a result of oxygen availability, metabolic imaging is often performed in conjunction with a determination of myocardial blood flow (MBF).…”

Section: Normal Myocardial Metabolism and Metabolic Imagingmentioning

confidence: 99%

Myocardial metabolic and receptor imaging in idiopathic dilated cardiomyopathy

et al. 2002

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“…This could be a consequence of the enhanced formation of glycerol-3-phosphate because of a higher NADH/ NAD + ratio and subsequent reesterification of the liberated free fatty acid with glycerol-3-phosphate. An increased incorporation of free fatty acids in endogenous lipids has been found during simultaneous infusion with lactate (2,42). Therefore it can be concluded that also in the normoxic heart the triglyceride-free fatty acid cycle is operative.…”

Section: Discussionmentioning

confidence: 90%

Enhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart

et al. 1989

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We studied lipolysis in the isolated rat heart, measured as glycerol release during anoxia, low-flow ischemia and subsequent reperfusion. It was found that the rate of lipolysis was enhanced during ischemia/anoxia while the lipase activities in tissue extracts involved in the myocardial lipolysis and the amount of triglycerides were not affected. This indicates the dominant occurrence of a lipolysis-reesterification principle in ischemic and anoxic tissue. A common observation of ischemia/anoxia is an increase in the tissue NADH/NAD+ ratio. Therefore we investigated the effect of lactate and malate, both of which enhance the tissue redox state on myocardial lipolysis. Perfusion in the presence of lactate (10 mM) and malate (10 mM) both stimulated myocardial lipolysis by about five times. This suggests that the rate of reesterification of product fatty acids to triglycerides, which is determined by the NADH/NAD+ ratio, because of the increased formation of glycerol 3-phosphate from dihydroxy acetone phosphate, plays an important role in the regulation of lipolysis. The existence of triglyceride-fatty acid-triglyceride cycle is discussed.

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“…They concluded that lactate reduces the oxidation of radiolabeled palmitate in cardiac cells and enhances the incorporation of label in endogenous lipid stores. Scintigraphic studies performed by Visser and colleagues [18,21] with iodine-labeled fatty acid analogues in dogs and human volunteers provided the same kind of information.…”

Section: Plasma Lactate and The Interpretation Of Metabolic Imaging Tmentioning

confidence: 82%

“…It should be kept in mind that in the present experimental set up no fatty acids were added to the perfusion medium. Hence, it is tempting to state that lactate-induced incorporation of exogenous radiolabeled fatty acids in cardiac triacylglycerols [17,18,20,21] is also accompanied by increased hydrolysis of triacylglycerols to prevent cardiac lipid-osis. Since lactate decreased the half-time values of radioactivity incorporated in the endogenous triacylglycerol pool from 91 to 51 min in dog hearts perfused in situ with 131I-heptadecanoic acid the conclusion can be drawn that also in the in vivo heart the turnover rate of the neutral lipid pool is enhanced by lactate [21].…”

Section: The Effect Of Lactate On Endogenous Esterified Lipid Storesmentioning

confidence: 99%

Interrelationship between lactate and cardiac fatty acid metabolism

Vusse¹,

Groot

1992

Mol Cell Biochem

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This overview is presented, in the main, to summarize the following aspects of lactate and cardiac fatty acid metabolism: 1. The utilization of exogenous carbohydrates and fatty acids by the heart. 2. The competition between lactate and fatty acids in cardiac energy metabolism. 3. The effect of lactate on endogenous triacylglycerol homeostasis. 4. Lactate-induced impairment of functional recovery of the post-ischemic heart. 5. The effect of lactate on lipid metabolism in the ischemic and post-ischemic heart. 6. The consequences of hyperlactaemia for cardiac imaging.

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Radioiodinated free fatty acids; can we measure myocardial metabolism?

Cited by 16 publications

References 13 publications

Myocardial metabolic and receptor imaging in idiopathic dilated cardiomyopathy

Myocardial metabolic and receptor imaging in idiopathic dilated cardiomyopathy

Enhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart

Interrelationship between lactate and cardiac fatty acid metabolism

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