Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

Liu, Nian; Shi, Yanyun; Guo, Jingru; Hai, Li; Wang, Qiang; Song, Menglin; Shi, Zhiyuan; He, Le; X, Su; Xie, Jin; Sun, Xiaolian

doi:10.1007/s12274-019-2549-7

Cited by 16 publications

(5 citation statements)

References 34 publications

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“…131 I is a clinical used radioisotope with both diagnosis and therapy function. [ 12 ] The ZGCs could also serve as a nanoplatform to effectively deliver 131 I into tumor cells for enhanced RT. The combination of self‐generated ROS and RT demonstrated excellent tumor inhibition both in vitro and in vivo without the requirement of external light excitation.…”

Section: Introductionmentioning

confidence: 99%

Radioiodinated Persistent Luminescence Nanoplatform for Radiation‐Induced Photodynamic Therapy and Radiotherapy

Wang

Liu

Hou

et al. 2020

Adv Healthcare Materials

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Radionuclide with Cerenkov radiation (CR) can serve as an internal excitation source to activate photosensitizers for photodynamic therapy (PDT) in deep tumor. However, the low efficiency of CR limits its therapeutic efficacy. A 131I labeled zinc tetra(4‐carboxyphenoxy) phthalocyaninate (ZnPcC4) conjugated Cr3+‐doped zinc gallate (ZnGa2O4:Cr3+, ZGCs) nanoplatform (131I‐ZGCs‐ZnPcC4) is developed for radiotherapy (RT) and radiation‐induced PDT. 131I can not only activate ZGCs for long‐lasting luminescence via both Cerenkov luminescence (CL) and ionizing radiation, which further continuously activate photosensitizer ZnPcC4 for PDT, but also can directly kill cancerous cells. This 131I‐ZGCs‐ZnPcC4 exhibits excellent tumor inhibition both in vitro and in vivo. Combining self‐activated PDT and RT, it is believed that the 131I‐ZGCs‐ZnPcC4 can greatly benefit the deep tumor therapy.

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Section: Introductionmentioning

confidence: 99%

Radioiodinated Persistent Luminescence Nanoplatform for Radiation‐Induced Photodynamic Therapy and Radiotherapy

Wang

Liu

Hou

et al. 2020

Adv Healthcare Materials

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“…The peaks at 2,920 and 2,850 cm −1 are attributed to the -CH 3 and -CH 2 symmetric stretching, respectively [38], which indicates that the surface of the CNDs contains a series of hydrocarbon groups [35]. Stretching vibrations of C=O, C-C, and C-O-C are localized at about 1,630, 1,460, and 1,150 cm −1 , respectively [39,40]. The FTIR spectrum of the CNDs reveals that they have abundant hydrocarbon chains, carboxyl and hydroxy functional groups on the surface of the CNDs.…”

Section: Characterization Of the Cndsmentioning

confidence: 98%

Near-infrared carbon nanodots for effective identification and inactivation of Gram-positive bacteria

et al. 2021

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An unacceptable increase in antibacterial resistance has arisen due to the abuse of multiple classes of broad-spectrum antibiotics. Therefore, it is significant to develop new antibacterial agents, especially those that can accurately identify and kill specific bacteria. Herein, we demonstrate a kind of perilla-derived carbon nanodots (CNDs), integrating intrinsic advantages of luminescence and photodynamic, providing the opportunity to accurately identify and kill specific bacteria. The CNDs have an exotic-doped and π-conjugated core, vitalizing them near-infrared (NIR) absorption and emission properties with photoluminescence quantum yield of 21.1%; hydrophobic chains onto the surface of the CNDs make them to selectively stain Gram-positive bacteria by insertion into their membranes. Due to the strong absorption in NIR region, reactive oxygen species are in situ generated by the CNDs onto bacterial membranes under 660 nm irradiation, and 99.99% inactivation efficiency against Gram-positive bacteria within 5 min can be achieved. In vivo results demonstrate that the CNDs with photodynamic antibacterial property can eliminate the inflammation of the area affected by methicillin-resistant Staphylococcus aureus (MRSA), and enabling the wound to be cured quickly.

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“…Carbon dots (CDs), with their unique optical properties, excellent stability, and biocompatibility, are promising for preclinical or potential clinical applications [85]. Most studies on carbon dots have focused on their optical imaging applications, which face challenges such as the low quantum yield of carbon dots and limited tissue penetration of light [86,87]. To overcome these hurdles, Liu et al developed 2.5 nm tyrosine-based carbon dots (TCDs) with phenolic hydroxyl groups on the surface for direct 125 I labeling.…”

Section: Nonmetallic Nanoparticlesmentioning

confidence: 99%

Radiolabeled Tracing Techniques Illuminating Blood Pharmacokinetics in Nanomedicine

Zhou,

Zhang,

Wang

et al. 2024

Nano Biomedicine and Engineering

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In the realm of pharmaceutical advancement, the transformative prowess of nanotechnology shines through its precision-targeted drug delivery and amplified therapeutic effects. This paper ventures into the realm of radiolabeling techniques for unraveling the intricate choreography of drug kinetics within the bloodstream which encompass the delicate stages of absorption, distribution, metabolism, and excretion. Through the magical lens of the radiolabel, a real-time spectacle unfolds, providing invaluable insights into the safety and efficacy of nanomedicine interventions. Amid the labyrinthine complexities of drug-organism interactions and the lack of universal protocols for nanomedicine preparation, radiolabeling technology has emerged as a guiding constellation. The paper systematically assesses the methods commonly employed for pharmacokinetic studies, delves into the manifold advantages and techniques of radiolabel methods within the nanomedicine landscape, closely examines their application across a spectrum of pharmacokinetic studies and thoughtfully addresses the challenges they may pose. Embark on this illuminating odyssey-a journey that peers into the microcosm of nanomedicine, deciphering its dynamic interplay within the bloodstream through the luminary insights of radiolabeled tracing techniques.

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Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

Cited by 16 publications

References 34 publications

Radioiodinated Persistent Luminescence Nanoplatform for Radiation‐Induced Photodynamic Therapy and Radiotherapy

Radioiodinated Persistent Luminescence Nanoplatform for Radiation‐Induced Photodynamic Therapy and Radiotherapy

Near-infrared carbon nanodots for effective identification and inactivation of Gram-positive bacteria

Radiolabeled Tracing Techniques Illuminating Blood Pharmacokinetics in Nanomedicine

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