Radioiodination and biological evaluation of nizatidine as a new highly selective radiotracer for peptic ulcer disorder detection

Sanad, M. H.; Saleh, G. M.; Marzook, F. A.

doi:10.1002/jlcr.3541

Cited by 45 publications

(10 citation statements)

References 19 publications

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“…It was shown to be stable in saline for up to 48 hours. By contrast, in serum after 12 hours, the purity dropped to 97.0% and decreased to 85% at 48 hours …”

Section: Resultsmentioning

confidence: 87%

“…All radioactivity levels are expressed as average percent‐injected dose per gram tissue (%ID/gram ±S.D). Low thyroid uptake at all times indicates that the [ 125 I]iodorolipram compound is stable in vivo to enzymatic de‐iodination . [ 125 I]iodorolipram is distributed rapidly in most organs at 5 minutes p.i.…”

Section: Resultsmentioning

confidence: 99%

“…Window setting of 190 keV and 20% width for gamma‐imaging studies was used. After intravenous administration of radiolabeled [ 131 I]iodorolipram (injected dose 0.1‐mg rolipram in 0.5‐mL phosphate buffer [pH 7], activity 0.2 mCi), the animal was anesthetized according to Sanad et al The static images were stored in a 512 × 512 matrix size and acquisition times at 300 seconds. Scintigraphy was the diagnostic nuclear medicine test used in this study, where [ 131 I]iodorolipram was administered intravenously and the emitted gamma radiation captured by a gamma camera (Philips axis gamma 2) to form 2‐dimensional images.…”

Section: Methodsmentioning

confidence: 99%

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Radioiodination and bioevaluation of rolipram as a tracer for brain imaging: In silico study, molecular modeling and gamma scintigraphy

Sanad

Farag

Salama

2018

Labelled Comp Radiopharmac

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Brain imaging is considered one of the most fruitful applications of radioisotope scanning. Rolipram, a selective phospodiesterase-4 inhibitor, has been labeled using [ I] with chloramine-T (Ch-T) as an oxidizing agent. Factors, such as the amount of substrate, pH, the amount of oxidizing agent, temperature, and the reaction time, have been systematically studied to optimize the iodination process. In addition, bio-distribution studies have indicated that the brain uptake of [ I]iodorolipram is 7.6 ± 0.33 injected dose/g organ at 10 minutes post-injection, which cleared from the brain with time until it reaches 1.30 ± 0.17% at 1 hour post-injection. Therefore, iodorolipram could be considered as a potential, new selective radiotracer for brain imaging.

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“…It was shown to be stable in saline for up to 48 hours. By contrast, in serum after 12 hours, the purity dropped to 97.0% and decreased to 85% at 48 hours …”

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Radioiodination and bioevaluation of rolipram as a tracer for brain imaging: In silico study, molecular modeling and gamma scintigraphy

Sanad

Farag

Salama

2018

Labelled Comp Radiopharmac

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“…In an amber colored vial radioiodination conditions were scrutinized and optimized to maximize the yield of the labeled compound by using CAT (25-200μg) of freshly prepared solutions, dissolved in ethanol (1:1 v/v), different concentrations of PA (10-100 μg) dissolved in ethanol (1:1 v/v), pH (3)(4)(5)(6)(7)(8)(9), reaction time (5-120 min), and stability [19,20].…”

Section: Optimization Of Reactionmentioning

confidence: 99%

Distribution of Iodine125 Labeled Parathion and the Protective Effect of Dried Banana Peel in Experimental Mice

et al. 2021

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Parathion (PA) one of the organophosphorus pesticides, is widespread in agriculture crops. Several studies reported the detection of this pesticide residue in food at high concentrations. Accordingly, the purpose of this study was to determine the accumulation of iodine [ 125 I] labeled parathion ([ 125 I] PA) in mice organs and to study the protecting reflex of dried banana peel. In this study, two groups of mice were used. Iodine [ 125 I] labeled parathion (10 mg/kg body weight) was applied only to one group of mice. Meanwhile, [ 125 I] PA (10 mg/kg body weight) and dried banana peel (20% were added to the diet) were applied to the other group of mice. The mice were injected by [ 125 I] PA through the tail vein and were given the dried banana peel through the mouth. The mice were kept under observation for 180 min. for monitoring. The result of the first group of mice, which was injected with [ 125 I] PA, only indicated that [ 125 I] PA was distributed primarily in the kidneys (18.6%), liver (18.9%), and intestine (6.11%), after 180 min. In the second group of mice which received both [ 125 I] PA, and dried banana peels, [ 125 I] PA accumulated at a lower percentage in the kidneys (10.2%), liver (5.2%), and intestine (4.67%) after 180 min. These results indicated the decrease of [ 125 I] PA in the liver and kidneys could be due to the effect of dried banana peels, and draw attention to the use of agricultural waste to remove pesticide residues contaminating food and feed.

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“…Thyroid function can be assess with radiological examination and laboratory investigation of hormone of pituitarythyroid axis. For the radiological examination, Iodine-123 is the isotope of choice for medical imaging that concentrated in thyroid directly with a half-life to 13.22 hours and decays by emission of gamma radiation with an energy of 159 keV [15][16][17][18][19][20][21][22][23][24][25][26][27]. There is no report on the effect of shortterm and long-term effect of lithium therapyon the hypothalamic-pituitary-thyroid axis in Nepalese population.…”

Section: Introductionmentioning

confidence: 99%

Effects of Short-term and Long-termUse of Lithium on Thyroid Hormones in Nepalese Patients with Bipolar Disorder

Gupta

Raut

Bhattarai

et al. 2021

IJBcRR

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Background: Lithium has been used for decades as mood-stabilizing agents in the management of bipolar disorder and other condition with a manic component. However, some studies have also reported varying degrees of thyroid abnormalities associated with lithium therapy and effect of such therapy on thyroid function is unclear in this part of world. Therefore, we aimed to determine the effect of long term use of lithium on thyroidfunctionin the individual with bipolar disorder receiving lithium therapy. Methods: A total of 75 bipolar disorder patients (24 males, 51 females) who are under lithium therapy and equal number of control were recruited for this study. Diagnosis of bipolar disorder was made by psychiatrist according to ICD-10-DCR guidelines and DSM-IV criteria. Serum fT3, fT4 and TSH were measured by enhanced chemiluminescence immunoassay. Statistical analysis was performed using SPSS 20.0 version. Results: The prevalence of primary hypothyroidism and subclinical hypothyroidism were found significantly increased in lithium treated group (12% and 17%, respectively) which was further increased with duration of treatment. The mean fT3 and fT4 concentration is low in lithium treated group compared to control group.Butmean TSH level was found significantlyhigher in lithium treated group compared to control (9.67±12.47 vs. 3.41±3.69, p<0.005). Conclusion: Our findings indicate that use of lithium therapy is associated with higher degree of primary hypothyroidism and subclinical hypothyroidism and female are more susceptible for the thyroid dysfunction associated with lithium therapy.

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Radioiodination and biological evaluation of nizatidine as a new highly selective radiotracer for peptic ulcer disorder detection

Cited by 45 publications

References 19 publications

Radioiodination and bioevaluation of rolipram as a tracer for brain imaging: In silico study, molecular modeling and gamma scintigraphy

Radioiodination and bioevaluation of rolipram as a tracer for brain imaging: In silico study, molecular modeling and gamma scintigraphy

Distribution of Iodine125 Labeled Parathion and the Protective Effect of Dried Banana Peel in Experimental Mice

Effects of Short-term and Long-termUse of Lithium on Thyroid Hormones in Nepalese Patients with Bipolar Disorder

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