Radioiodination and biological evaluation of landiolol as a tracer for myocardial perfusion imaging: preclinical evaluation and diagnostic nuclear imaging

Abstract

<jats:title>Abstract</jats:title> <jats:p>The present work has assessed the ability and competency of radioiodinated landiolol that is considered a potential cardio selective imaging agent. Landiolol was radiosynthesized with [<jats:sup>131</jats:sup>I] using chloramine-T (Ch-T) as an oxidizing agent. To give high radiochemical yield of the [<jats:sup>131</jats:sup>I]landiolol reaching values of 98% with high stability up to 48 h. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoresis and high performance liquid chromatography (HPLC). Biodistribution studies indicated that [<jats:sup>131</jats:sup>I]landiolol gave high heart uptake ratio of [45.0±0.19% ID/g at 2 min post injection (p.i.)]. Therefore, [<jats:sup>131</jats:sup>I]landiolol could be considered as a novel tracer to image heart with high heart/blood ratio within 60 min.</jats:p>

Radioiodination of zearalenone and determination of Lactobacillus plantarum effect of on zearalenone organ distribution: In silico study and preclinical evaluation

“…scarification of animals was conducted after certain times (5 min, 15 min, 30 min, 60 min and 2 h) after injection. Organs were collected in addition to (Fresh blood, bone, and muscle tissues) then measured against prepared standard solution of the labeled substrate [ [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] , [95] , [96] , [97] , [98] , [99] , [100] ]. The mean percentage of the injected dose was calculated.…”

Facile one-pot strategy for radiopreprationof radioiodinated phenylpiracetam as a new highly selective radiotracer for brainimaging

“…A standard deviation (SD) for the mean value of the percentage of the supplied dose per gram was determined. It was calculated that muscle made up 40% of a person's body weight, whereas bone made up 10%, and blood made up 7% [71][72][73][74][75][76][77][78][79][80]. Experiments were conducted while corrections were used for background radiation and emission decays.…”

Radioiodination of balsalazide, bioevaluation, and characterization as a highly selective radiotracer for imaging of ulcerative colitis in mice

“…The yield was characterized by carbon nuclear magnetic resonance ( 13 C-NMR), 1 H-NMR, elemental analysis, and HPLC by following the protocols reported in the literature. [86][87][88][89][90][91][92][93][94][95]…”