Radioiodine‐131‐Labeled Theranostic Nanoparticles for Transarterial Radioembolization and Chemoembolization Combination Therapy of VX2 Liver Tumor

Abstract

In interventional treatment, the materials are administered into the blood supply artery and directly delivered to tumors, offering proper scenarios for nanomedicine potential clinical applications. Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are effective treatment methods for hepatocellular carcinoma (HCC), but postoperative residual tumor may result in intrahepatic recurrence and distant metastasis. The combination therapy of TACE and TARE based on multifunctional nanoparticles (NPs) is expected to overcome the drug resistance in hypoxic tumors and improve the therapeutic effect. Herein, BaGdF5 NPs were synthesized and then coated with polydopamine (PDA), conjugated with chemotherapeutic drug Cis‐Diamminedichloride platinum (CDDP), radiolabeled with therapeutic radionuclide 131I, yielding 131I‐BaGdF5@PDA‐CDDP NPs. The in vitro anti‐cancer effects of 131I‐BaGdF5@PDA‐CDDP NPs were confirmed using CCK‐8 and γ‐H2AX assays in Huh7 cells. Mixed with Lipiodol®, 131I‐BaGdF5@PDA‐CDDP NPs were injected into the hepatic artery via a microtubule to realize the TACE and TARE combination therapy in a rabbit VX2 liver tumor model. The results indicated that glucose metabolism was decreased obviously based on 18F‐FDG PET imaging and the apoptosis of tumor cells was increased. Furthermore, 131I and BaGdF5 NPs can be used for SPECT imaging and CT/MR imaging respectively, facilitating real‐time monitoring the in vivo biodistribution of 131I‐BaGdF5@PDA‐CDDP NPs.This article is protected by copyright. All rights reserved

Indocyanine green-loaded porphyrin covalent organic frameworks for photothermal cancer therapy

“…Following incubation for another 24 h, the cells were washed with PBS, and the cell viability was measured using the CCK-8 method. 41 To further study the photothermal effect of ICG@COF NPs, the cell staining experiment was carried out using calcein-acetyl hydroxymethyl ester (Calcein-AM) and propidium iodide (PI) as fluorochromes, which could stain the living and dead cells, respectively. Specifically, 4T1 cells (3 Â 10 3 ) were inoculated in 96-well plates with ICG@COF NPs.…”