Radioiodine Penetration through Intact Enamel with Uptake by Bloodstream and Thyroid Gland

Effects of high-dose major components in oral disinfectants on the cell cycle and apoptosis in primary human gingival fibroblasts in vitro

“…BEC is a major component in the oral disinfect Neostelin Green The minimum effective clinical concentration in the oral mucosa is 0.01-0.025% (2.8×10 -1 -7.1×10 -1 mM). Oral disinfectants are generally administered directly to the periodontium and oral mucosa from which they can enter the bloodstream and circulate body 20,21) through the Some of the components accumulate in periodontal pockets and under the oral mucosa or are concentrated in oral cells, such as gingival fibroblasts.…”

“…The effects of PVD-I are generally thought to be caused by the nonspecific oxidizing effects of released free iodine 13,14) . Oxidative stress can lead to apoptosis, cell cycle arrest, reduced cell proliferation, and altered cell differentiation [19][20][21] . We found that the IC50 of PVD-I for human gingival fibroblasts cells was 2.6×10 -1 mM, while those for BEC and BAC were 1.3×10 -2 mM and 6.0×10 -3 mM, respectively (Fig.…”

“…At the cellular level, ROS can produce apoptosis, cell cycle arrest, reduced proliferation, and modulation of differentiation [17][18][19] . These components of oral disinfectants affect the oral mucosa directly with a short exposure; however, some of the components accumulate in periodontal pockets and under the oral mucosa or are concentrated in oral cells [20][21] . Therefore, this study investigated the Received Apr 15, 2009: Accepted Oct 19, 2009 cell cycle and apoptosis of gingival fibroblasts exposed to high-dose oral disinfectants.…”

Sensory mechanisms in dentine: A literature review of light microscopy (LM), transmission microscopy (TEM), scanning microscopy (SEM) & electro physiological (EP) tooth sensitivity: Is the ciliary organelle on the odontoblast the elusive primary nociceptor?

“…These observations were corroborated in 1951 by Bartelstone who demonstrated the in vivo passage of radiolabelled iodine through intact vital enamel & dentine to the thymus within 15-minutes after application to the enamel surface [52]. Fifty years after Neill's 1842 thesis- Gysi 1 st reported the clinical nature of fluid movement from the cavity floor as the cause of human tooth sensitivity [53].…”

A timeline of biological assessments: Our nonspatial continuum

“…The dynamic nature of microleakage In 1947, Dr. Bartlestone demonstrated that open enamel channels readily permitted microleakage of radiolabelled agents from the oral surface into the vital pulp & vascular system within 15-minutes [116]. A few years later Dr. Nelson used various research methods (e.g.…”