Radioiodine therapy in Graves' disease based on tissue-absorbed dose calculations: effect of pre-treatment thyroid volume on clinical outcome

Onset Age is Associated with Outcome of Radioiodine Therapy in Graves' Disease

“…It has been reported that the patients with Graves' disease have a higher rate of thyroid gland cancer as compared with normal individuals or patients with other thyroid gland diseases, although once the thyroid tissues are decreased in size by radioiodine therapy, the frequency of carcinogenesis in fact decreases [18]. Patients who become hypothyroid function have low post-therapeutic thyroid volumes [9,10,19]. Therefore, the recommended treatment objective should be to achieve a hypofunctional thyroid within a year, while investigating the factors related to the outcome of thyroid function.…”

“…Since patients with long duration of disease might have to take antithyroid medication for long periods of time, this is also one of the reasons why longer duration affects thyroid gland function. It was reported that thyroid glands of greater weight or larger size need more radiation [7][8][9][10]. Some studies have attempted to determine the optimal radioiodine dose based on weight or size of the thyroid gland [6,9].…”

“…There have been few reports concerning the relationship between the predictive factors and outcome of radioiodine therapy in Japan [6,10,11]. Similar to European countries, antithyroid medication is first choice for the treatment of Graves' disease in Japan [13,14].…”

“…It has been reported that males [3,4], younger patients [5,6], patients with more severe hyperthyroidism [5,6], patients with goiters of larger size [5][6][7][8][9][10][11][12], and patients with high TRAb value [11,12] were less likely to be cured after radioiodine therapy. Therefore it is possible to reduce the radioiodine dose for the other patients.…”

Radiojodoterapia w chorobie Gravesa-Basedowa — czynniki wpływające na skuteczność leczenia w oparciu o analizę retrospektywną

“…Some authors use the old formula created by Marinelli, which takes into account the volume of the thyroid, its iodine uptake capacity, as well as the turnover of radioiodine and its thyroid-absorbed dose [16][17][18]. Others recommend using an empirically established value of 131 I activity per one gram of thyroid tissue; and others apply fixed activities, often administered repeatedly at certain intervals, until effective [19][20][21].…”