Radioiodine therapy induced sialadenitis versus chronic idiopathic sialadenitis—Presentation and outcomes

Gilat, Hanna; Vainer, Igor; Avishai, Gal; Maymon, Shiri Lea; Alkan, Uri; Hod, Roy; Robenshtock, Eyal; Friedman, Sivan; Shpitzer, Thomas

doi:10.1002/hed.26741

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Salivary gland fibrosis, as assessed by both sonography and pathology, is related to short-term adverse outcomes, including dysphagia and local pain, and long-term adverse outcomes, including sialectasia, recurrent sialadenitis, and cosmetic malformations. 21 An et al 22 reported the dose-dependent development of chronic salivary gland symptoms, mainly pain and swelling, after RAI treatment. Changes occurred in 11% of patients who received 30 mCi and 50% of patients who received 100 mCi or higher.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, while external beam radiation is related to additional measurable morbidity compared with RAI alone, 20 both modalities may have similar adverse effects in terms of salivary gland damage. Salivary gland fibrosis, as assessed by both sonography and pathology, is related to short‐term adverse outcomes, including dysphagia and local pain, and long‐term adverse outcomes, including sialectasia, recurrent sialadenitis, and cosmetic malformations 21 …”

Section: Discussionmentioning

confidence: 99%

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Ultrasonographic Features of Salivary Glands after Radioiodine Therapy in Patients with Thyroid Cancer

et al. 2022

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Objective: Chronic sialadenitis is the most common complication of radioactive iodine (RAI) treatment. The aim of the study was to ascertain sonographic features of the major salivary glands in patients with papillary thyroid cancer (PTC) treated with RAI.Methods: The database of a tertiary medical center was retrospectively searched for consecutive patients who underwent total thyroidectomy for PTC in 2011-2020 with ultrasound follow-up after 1 year. Changes in ultrasound features of the major salivary glands were compared between patients treated or not treated with RAI postoperatively.Results: The cohort included 158 patients, of whom 109 (69%) were treated postoperatively with RAI (mean dose, 131 mCi) and 49 were not (control group). Sonographic changes were observed in the major salivary glands in 43% of the study group and 18% of the control group (p = 0.002), including coarse echotexture, decreased echogenicity, fibrosis, and atrophy. Higher RAI doses were significantly correlated with the prevalence and severity of glandular changes (p < 0.0001).Conclusion: RAI treatment following thyroidectomy is associated with a dose-response effect and adverse changes in the major salivary glands and should be prescribed carefully.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Features of Salivary Glands after Radioiodine Therapy in Patients with Thyroid Cancer

et al. 2022

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Predictors of response to sialendoscopy for patients with chronic non-obstructive Sialadenitis versus radioiodine induced Sialadenitis

Chen,

Kim,

Odigie

et al. 2025

American Journal of Otolaryngology

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Usefulness of Stensen’s Duct Steroid Irrigation in Patients With Chronic Sialadenitis of the Parotid Gland

Choi¹,

Kim²,

Lee³

et al. 2023

Korean J Otorhinolaryngol-Head Neck Surg

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Background and Objectives Inflammatory and obstructive diseases of the salivary glands can cause recurrent pain, swelling, and dry mouth, significantly affecting the quality of life. In most cases, symptoms improve after medical treatment, but if symptoms persist or recur, other treatment methods should be considered. The purpose of this study was to evaluate the therapeutic effect of salivary duct steroid irrigation in refractory chronic sialadenitis.Subjects and Method A retrospective study was conducted on 19 patients who underwent Stensen’s duct steroid irrigation from January 2016 to December 2021. All patients enrolled in study had no improvement of symptoms after medical treatment. The clinical characteristics including etiology, location, symptom duration, underlying disease, treatment response and complications of the patients were analyzed.Results Stensen’s duct steroid irrigation was effective in 12 of 19 patients (63%), of which 5 (26%) showed complete disappearance of symptoms. There was no difference in the treatment effect by etiology. The rate of non-response to treatment was high when the symptom duration was more than one year. Temporary parotid gland swelling occurred in two patients after irrigation, while other side effects such as bleeding and infection did not occur.Conclusion Salivary duct steroid irrigation is a simple and safe procedure, which may be considered as a treatment method for medically refractory chronic sialadenitis.

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Radioiodine therapy induced sialadenitis versus chronic idiopathic sialadenitis—Presentation and outcomes

Cited by 4 publications

References 30 publications

Ultrasonographic Features of Salivary Glands after Radioiodine Therapy in Patients with Thyroid Cancer

Ultrasonographic Features of Salivary Glands after Radioiodine Therapy in Patients with Thyroid Cancer

Predictors of response to sialendoscopy for patients with chronic non-obstructive Sialadenitis versus radioiodine induced Sialadenitis

Usefulness of Stensen’s Duct Steroid Irrigation in Patients With Chronic Sialadenitis of the Parotid Gland

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