Candidiasis as an infection spread all over the oral cavity finds the appropriate conditions to show the clinical appearance, mainly in patients with reduced immune status. For the purpose of facilitating the case diagnosis of case studies, supported also in literature, the study aims at the application of blue methylene as an indicator of Candida colonies in various areas of oral cavity mucosa. Identification with blue methylene is a simple procedure that reduces the microbiological stages of planting and testing the candidate's candidacy, shortening the timing of diagnosis, and performing this procedure at the dental chair. Based on the literature, though few, in number, the references indicate Lugol's application, the 2% iodine solution as a candidate for treatment of candidiasis previously detected with blue methylene in the patients involved in the studies referred to in the literature. Iodine delivery in patients is progressively carried out, ranging from 1 drop to day, 2.5 mg, to a maximum of 5 drops/day, 12.5 mg, proportionally divided by day. Patients involved declare for lack of iodine allergies, and during subtype in this therapy, were kept under control for systemic sensations previously unpublished but based on literature, as sleeping disturbances, worries in the nutritional constituents of the individual diet, or any other concern.