Radioiodotherapeusis

Williams, Robert H.; Towery, Beverly T.; Jaffe, Herbert; Rogers, Walter F.; Tagnon, R

doi:10.1016/0002-9343(49)90409-x

Cited by 27 publications

(6 citation statements)

References 5 publications

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“…There has been considerable experience of prescribing antithyroid drugs before or after 131 I therapy since the first description of their adjunctive role more than 50 years ago (43). Indeed, a survey of members of the American Thyroid Association found that 31% of correspondents prescribe antithyroid drugs before and 40% after 131 I (2).…”

mentioning

confidence: 99%

Controversies in radioiodine therapy: relation to ophthalmopathy, the possible radioprotective effect of antithyroid drugs, and use in large goitres

Bonnema

Bartalena

Toft

et al. 2002

European Journal of Endocrinology

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In routine use for more than 50 years, radioiodine ( 131 I) is generally considered safe and devoid of major side effects. Therefore, it is surprising that relatively many aspects of radioiodine therapy are controversial, as illustrated by recent international questionnaire studies. Our review aims at highlighting three of these areas -namely, the influence of 131 I on the course of Graves' ophthalmopathy, the possible radioprotective effects of antithyroid drugs, and the use of 131 I in large goitres. 131 I therapy carries a small (but definite) risk of causing progression of Graves' ophthalmopathy. Identification of risk factors (thyroid dysfunction, high level of thyroid-stimulating hormone (TSH) receptor antibodies, cigarette smoking) allows the identification of patients at risk and the institution of concomitant glucocorticoid treatment, thereby hindering progression of eye disease.On the basis, largely, of retrospective data, it appears that carbimazole (or methimazole), if stopped 3-5 days before treatment, does not influence the outcome of 131 I therapy. Simultaneous thyrostatic medication most probably reduces the efficacy of 131 I, as does restarting it within 7 days. Propylthiouracil seems to have a more prolonged radioprotective effect than carbimazole.Surgery is the treatment of first choice in patients with a large goitre. However, in the case of patient ineligibility or preference, 131 I therapy may be an option. The treatment has a favourable effect on tracheal compression and inspiratorycapacity, but the reduction in thyroid volume is only 30-40%. Inpatient treatment, necessitated by the large doses, makes the treatment cumbersome.Controversy related to radioiodine therapy is mainly based on the lack of adequate prospective randomised studies comparing efficacy, side effects, cost and patient satisfaction.

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confidence: 99%

Controversies in radioiodine therapy: relation to ophthalmopathy, the possible radioprotective effect of antithyroid drugs, and use in large goitres

Bonnema

Bartalena

Toft

et al. 2002

European Journal of Endocrinology

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“…Half-life and uptake can be determined for each patient before treatment, and an estimate made of the size of the gland. Some American groups have tried to evolve short cuts to dosage assessment such as by gland size (Williams, Jaffe, et al, 1949), level fRMSH MEDICAL JOURNAL RADIOACTIVE IODINE i-I of toxicity and gland size (Gordon and Albright, 1950), and so on, and Feitelberg et al (1950) assume a biological half-life in their dosage assessment of six days, an assumption which study of Table I shows to be unwarranted.…”

Section: Discussionmentioning

confidence: 99%

“…Radioactive iodine is therefore a therapeutic weapon with which highly specific treatment can be given to one particular type of tissue-thyroid gland tissue that concentrates iodine. Dosage The problem of the selection of the correct number of millicuries of the isotope in the drink to be given to each patient is of fundamental importance and is dependent on several factors, reviewed by Williams, Jaffe, et al (1949). Most groups of investigators aim at giving a drink containing about 100-200 ,uc.…”

Section: Principles Involved In Treatment With Radioactivementioning

confidence: 99%

Treatment of Thyrotoxicosis with Radioactive Iodine

Blomfield¹,

Macgregor²,

Miller³

et al. 1951

BMJ

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“…Gland size calculated from scintiscan did not correspond well with measurements by ultrasound or palpation.A method for accurately measuring thyroid gland size would facilitate precise calculation of therapeutic radioiodine dosage and provide an objective record of gland size in patients with non-toxic goitre. Assessment of thyroid size by palpation (Soley et al, 1949;Williams et al, 1949;Smith & Wilson, 1967) and by thyroid scan (Myhill et al, 1965) is inaccurate and we report the use of ultrasound for this purpose. Results are compared with measurements by palpation, by thyroid scintiscan and at operation.…”

mentioning

confidence: 88%

Measurement of Thyroid Size by Ultrasound, Palpation and Scintiscan

Tannahill

Hooper

England

et al. 1978

Clinical Endocrinology

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Thyroid gland size was calculated from grey-scale ultrasound images in twenty patients with goitre. Results were compared with measurements by palpation and in some cases with measurements by scintiscan and at operation. There was a good correlation between ultrasound measurements and both the size of surgical specimens and clinicians' estimations, although clinicians under-estimated the size of large (greater than 40 ml) goitres compared with ultrasound and surgical specimens. Gland size calculated from scintiscan did not correspond well with measurements by ultrasound or palpation.

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Radioiodotherapeusis

Cited by 27 publications

References 5 publications

Controversies in radioiodine therapy: relation to ophthalmopathy, the possible radioprotective effect of antithyroid drugs, and use in large goitres

Controversies in radioiodine therapy: relation to ophthalmopathy, the possible radioprotective effect of antithyroid drugs, and use in large goitres

Treatment of Thyrotoxicosis with Radioactive Iodine

Measurement of Thyroid Size by Ultrasound, Palpation and Scintiscan

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