Radioisotope residues and residues of dichlorvos and its metabolites in pregnant sows and their progeny dosed with carbon-14-labeled dichlorvos or chlorine-36-labeled dichlorvos formulated as PVC pellets

Potter, John C.; Boyer, Alvin C.; Marxmiller, Ronald L.; Young, Robert B.; Loeffler, Josef E.

doi:10.1021/jf60188a038

Cited by 8 publications

(2 citation statements)

References 8 publications

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“…In another report, Rosenblum et al (1972) reported on persistent nonmetabolite residues in turkeys receiving ronidazole-14C, an imidazole antiparasitic agent. Similar problems were reported by Potter et al (1973), who detected nonmetabolite radioactive residues when dichlorvos-14C was administered to pregnant sows. To explore this possibility, the following limited studies were performed.…”

Section: Resultssupporting

confidence: 82%

Metabolic and tissue residue studies on parbendazole in sheep

Cj¹,

Ja²,

Wl³

et al. 1974

J. Agric. Food Chem.

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Section: Resultssupporting

confidence: 82%

Metabolic and tissue residue studies on parbendazole in sheep

Cj¹,

Ja²,

Wl³

et al. 1974

J. Agric. Food Chem.

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“…The data show large variations in the 14C content of different tissues similar to those reported (Potter et al, 1973a) to occur after oral treatment. The isolation of key metabolites in pure form showed that glycine, as in the feeding experiments (Page et al, 1972a,b) had the highest specific activity, 9 µ / (266 dpm/mg), followed closely by serine with 8.8 µ / (186 dpm/mg).…”

Section: Analytical Methods and Resultssupporting

confidence: 80%

Long-term exposure of swine to a carbon-14-labeled dichlorvos atmosphere

Loeffler¹,

Potter²,

Scordelis³

et al. 1976

J. Agric. Food Chem.

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SWINE EXPOSURE TO |iC]DICHLORVOSincreased at a faster rate when fruits approached the ripe stage. All varieties attained almost the same percentage, about 90% of dry matter when ripe.The protein content at the green stage as shown in Table I is the highest and it is twofold higher than the concentration of the ripe stage (dry weight basis). There is no significant difference in the protein content of the three varieties studied with the same stage.Amino acid compositions of the three varieties are given in Table II. In all varieties there are identical patterns of amino acid composition and 17 amino acids were detected. The protein-rich green stage contained the highest concentration of amino acids with more glutamic acid, aspartic acid, lysine, leucine, alanine, and serine than the other two stages of maturity. The data in Table II show that total and free amino acids concentrations are considerably different in the three varieties for the three stages of maturity. This seems to be associated with the protein contents of the three stages of development (Table I). The data also show for the three varieties at the yellow and completely ripened stages that glutamic acid, aspartic acid, lysine, leucine, proline, and glycine were present at high concentrations.

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Metrifonate

et al. 1978

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The organophosphorus compound 0,0-dimethyl-(1-hydroxy-2,2,2-trichloroethyl)-phosphonate was introduced as an insecticide, trichlorfon, in 1952 (Lorenz et al., 1955) and as a drug, metrifonate, in the treatment of schistosomiasis in 1960 (Lebrun and Cerf, 1960). This organophosphorus compound is unique in that it has been claimed not to be a direct acting cholinesterase inhibitor but being transformed nonenzymatically into an active component dichlorvos, 2, 2-dichlorovinyl dimethyl phosphate (DDVP). The evidence for this transformation has mostly been indirect. Recently it has been proved chemically and quantitatively that this transformation occurs in the animal body (Nordgren et al., 1978). Metrifonate is the sole organophosphorus compound currently studied clinically in schistosomiasis. A substantial therapeutic effect is obtained only in Schistosoma haematobium infections. In this review on available data of metrifonate it is suggested that further more detailed studies of both S. haematobium and S. mansoni are necessary. This should include studies of the enzymic properties of the worms and the reaction of their esterases towards both metrifonate and DDVP as well as the pharmacokinetics of these compounds in man. In addition there are still unsolved discrepancies reported regarding organ toxicity of the compound which may, however, be due to different grades of parity of the test material.

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Radioisotope residues and residues of dichlorvos and its metabolites in pregnant sows and their progeny dosed with carbon-14-labeled dichlorvos or chlorine-36-labeled dichlorvos formulated as PVC pellets

Cited by 8 publications

References 8 publications

Metabolic and tissue residue studies on parbendazole in sheep

Metabolic and tissue residue studies on parbendazole in sheep

Long-term exposure of swine to a carbon-14-labeled dichlorvos atmosphere

Metrifonate

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