Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts

Goel, Muskan; Mackeyev, Yuri; Krishnan, Sunil

doi:10.1186/s12645-023-00165-y

Cited by 41 publications

(22 citation statements)

References 282 publications

(312 reference statements)

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“…Nanoparticles can be connected to a pharmacological vector (labelled nanoparticles) that recognizes a membranous target to facilitate their internalization. The “enhanced permeability ratio (EPR)” effect also enables them to penetrate the tumor more easily due to a difference in vascular permeability between healthy and tumor tissues, conferring much better diffusion of particles in tumor tissues [ 83 ].…”

Section: Radiation-sensitizing Nanoparticlesmentioning

confidence: 99%

A radiobiological perspective on radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma

Li,

Tan,

Wei

et al. 2024

Rep Pract Oncol Radiother.

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Background This article aimed to compile and summarize clinically relevant literature in radiation therapy, and to discuss the potential in radioresistant and radiosensitive head and neck cancer. Study Design Narrative review. Materials and methods Google Scholar, PubMed and the Cochrane Library were retrieved using combined key words such as “radiotherapy” and “head and neck cancer”. Search strings additionally queried were “radioresistant”, “radiosensitive”, “head and neck region”, “squamous cell carcinoma”, in combination with Boolean Operators ‘AND’ and ‘OR’. Subsequently, the resulting publications were included for review of the full text. Results Radiotherapeutic response currently in clinical observation referred to HNSCC scoping were selected into this review. The compiled mechanisms were then detailed concerning on the clinical significance, biological characteristics, and molecular function. Conclusions Brachytherapy or/and external-beam radiotherapy are crucial for treating HNSCC, especially the early stage patients, but in patients with locally advanced tumors, their outcome with radiation therapy is poor due to obvious radioresistance. The curative effects mainly depend on the response of radiation therapy, so an updated review is needed to optimize further applications in HNSCC radiotherapy.

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Section: Radiation-sensitizing Nanoparticlesmentioning

confidence: 99%

A radiobiological perspective on radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma

Li,

Tan,

Wei

et al. 2024

Rep Pract Oncol Radiother.

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“…Current diagnostic approaches involve imaging (MRI, CT, ultrasound), biopsies, and/or bloodwork, in conjunction with patient symptoms. Advances in imaging techniques involve the use of radioactive particles to improve resolution and to identify specific cell-types 40 . Despite improvements in imaging technologies, these approaches are often costly, and require additional tissue or blood biopsies to achieve high confidence diagnoses.…”

Section: Mrna Cargoes As Biomarkers Of Diseasementioning

confidence: 99%

Extracellular vesicles as carriers of mRNA: Opportunities and challenges in diagnosis and treatment

Kirian,

Steinman,

Jewell

et al. 2024

Theranostics

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Extracellular vesicles (EVs) are produced by all cells in the body. These biological nanoparticles facilitate cellular communication through the transport of diverse cargoes, including small molecules, proteins, and nucleic acids. mRNA cargoes have gained particular interest given their role in the translation of functional proteins. As a biomarker platform, EVs can be found in nearly all biofluids—blood, mucus, urine, cerebrospinal fluid, and saliva—providing real-time insight into parent cell and tissue function. mRNAs carried by EVs are protected from degradation, resulting in improved detection compared to free mRNA, and recent work demonstrates promising results in using these mRNA cargoes as biomarkers for cancer, neurological diseases, infectious diseases, and gynecologic and obstetric outcomes. Furthermore, given the innate cargo carrying, targeting, and barrier crossing abilities of EVs, these structures have been proposed as therapeutic carriers of mRNA. Recent advances demonstrate methods for loading mRNAs into EVs for a range of disease indications. Here, we review recent studies using EVs and their mRNA cargoes as diagnostics and therapeutics. We discuss challenges associated with EVs in diagnostic and therapeutic applications and highlight opportunities for future development.

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“…With interesting properties such as a large surface-area-to-volume ratio, high radionuclide loading, and straightforward synthetic routes, they have been demonstrated as attractive vectors for the delivery of radioactivity in TRT. The use of nanomaterials in TRT is beyond the scope of this review but is detailed elsewhere [ 44 , 45 , 46 ].…”

Section: Vector Designmentioning

confidence: 99%

Optimizing the Safety and Efficacy of Bio-Radiopharmaceuticals for Cancer Therapy

et al. 2023

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The precise delivery of cytotoxic radiation to cancer cells through the combination of a specific targeting vector with a radionuclide for targeted radionuclide therapy (TRT) has proven valuable for cancer care. TRT is increasingly being considered a relevant treatment method in fighting micro-metastases in the case of relapsed and disseminated disease. While antibodies were the first vectors applied in TRT, increasing research data has cited antibody fragments and peptides with superior properties and thus a growing interest in application. As further studies are completed and the need for novel radiopharmaceuticals nurtures, rigorous considerations in the design, laboratory analysis, pre-clinical evaluation, and clinical translation must be considered to ensure improved safety and effectiveness. Here, we assess the status and recent development of biological-based radiopharmaceuticals, with a focus on peptides and antibody fragments. Challenges in radiopharmaceutical design range from target selection, vector design, choice of radionuclides and associated radiochemistry. Dosimetry estimation, and the assessment of mechanisms to increase tumor uptake while reducing off-target exposure are discussed.

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Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts

Cited by 41 publications

References 282 publications

A radiobiological perspective on radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma

A radiobiological perspective on radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma

Extracellular vesicles as carriers of mRNA: Opportunities and challenges in diagnosis and treatment

Optimizing the Safety and Efficacy of Bio-Radiopharmaceuticals for Cancer Therapy

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