Radiolabeling optimization and characterization of 68 Ga labeled DOTA–polyamido-amine dendrimer conjugate – Animal biodistribution and PET imaging results

Ghai, Aanchal; Singh, Baljinder; Hazari, Puja Panwar; Schultz, Michael K.; Parmar, Ambika; Kumar, Pardeep; Sharma, Sanjiv; Dhawan, D. K.; Mishra, Anil K.

doi:10.1016/j.apradiso.2015.07.021

Cited by 44 publications

(25 citation statements)

References 30 publications

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“…Conversely, anionic 125 I-labelled PAMAM dendrimers showed longer circulation rates in the blood stream, but still presenting some liver uptake (Maiik et al, 2000). Yet, lower generations circulated longer time periods in the blood, independently of the charge or modification, as in the particular case of PEGylated dendrimers (Bugno, Hsu, Pearson, Noh, & Hong, 2016;Ghai et al, 2015;Khor et al, 2016;Maiik et al, 2000;Nance et al, 2015;Zarebkohan et al, 2015). This may be correlated into some extent with the higher molecular weight of the system, molecular architecture, and surface functionality that still no precise associations been yet established.…”

Section: Systemic Effects Of Dendrimeric Nanosystemsmentioning

confidence: 99%

Dendrimers: Breaking the paradigm of current musculoskeletal autoimmune therapies

Rodrigues

Oliveira

Santos

et al. 2018

J Tissue Eng Regen Med

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The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents that, regardless of some good results in clinical outcomes, are well known for several systemic secondary side effects. Dendrimers are custom-made nanoparticles with proved clinical potential, displaying proper size, chemistries, immunomodulatory, and anti-inflammatory properties. This has directed their potential use as drug delivery systems for cancer therapy, for instance. This review manuscript discloses the hidden potential behind dendrimers as alternative viable solutions to treat RA and MS, by focusing in the most recent reports describing the use of dendrimers for suppressing inflammation and possibly preventing disease progression. The advantages of their use as compared with current applied therapies is also discussed herein.

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Section: Systemic Effects Of Dendrimeric Nanosystemsmentioning

confidence: 99%

Dendrimers: Breaking the paradigm of current musculoskeletal autoimmune therapies

Rodrigues

Oliveira

Santos

et al. 2018

J Tissue Eng Regen Med

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“…150 Of the radionuclides used in clinical practice of PET, Gallium-68 (half-life, t 1/2 = 68-min) exhibits positron emission intensity >87%. 152 In a recent report, 153 multifunctional dendrimers were chelated and readily labeled with positron emitting nuclides such as 64 Cu. 152 In a recent report, 153 multifunctional dendrimers were chelated and readily labeled with positron emitting nuclides such as 64 Cu.…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

PAMAM dendrimer based targeted nano-carrier for bio-imaging and therapeutic agents

2016

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In the last several decades, researchers have focused on developing suitable drug carriers to deliver pharmaceutical agents to treat cancer diseases. PAMAM dendrimers have been studied as potential delivery systems to targeting, imaging, and/or deliver therapeutic agents specifically to diseased tissues because of their unique properties, such as: multiple functionalities at the periphery or in the cavity, biocompatibility, tunable size, and monodispersity. Anti-cancer agents may be incorporated into the interior void space or conjugated to the surface of PAMAM to enhance the delivery of cytotoxic drugs. In addition, targeting ligands can also be attached to the dendrimer surface to allow active targeting and minimize harm to normal cells. In summary, this review highlights the contributions of PAMAM dendrimers to the field of nanotechnology with the intent to aid researchers in exploring dendrimers for targeted drug delivery, contrasting and bio-image agents. with specific ligands. 11 As previously reviewed, several polymeric nanocarriers can be prepared from both natural polymers, such as albumin, hyaluronic acid, and chitosan, and synthetic polymers, such as poly acrylamide (PAA), poly lactic acid (PLA), poly glycolic acid (PGA), poly(lactide-co-glycolide) (PLGA) and dendrimers. 12The purpose of this review is to provide readers an overview of well-defined PAMAM dendrimer nanomaterials which are available and may be of interest for cancer-related medical applications such as drug delivery and bio-imaging modalities. Therefore, the current review mainly focuses on the recent publications related to the development of PAMAM dendrimers for targeting and bio-imaging-guided drug delivery, as well as multifunctional dendrimer nanocomplexes. A brief introduction is also given for the in vitro and in vivo diagnosis of cancer and with a brief concluding remarks as well as future prospects of the topic. DendrimerDendrimers are a family of 3D nano-sized macromolecules exhibiting highly branched architecture initially reported by Fritz Vogtle in 1978 and synthesized by Donald Tomalia and George R. Newkome in the 1980s. [13][14][15] The name "dendrimer" comes from two Greek words dendron, which means "tree branch like", and meros, which means "part of", and was first discovered by Tomalia et al. 13 Dendrimer is considered as the fourth new class of polymer structure, that demonstrates significant application in nanomedicine including drug delivery due to its unique platform for the construction of various multifunctional carriers. 14, 16-23 Poly (amidoamine) (PAMAM) dendrimers are a family of highly branched and monodispersed synthetic macromolecules with well-defined structure and composition. 24, 25 These polymers have internal cavities and peripheral functional groups that can be modified to better localize

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“…The emission of two divergent photons per decay allows the construction of three-dimensional images. Also, the advances in generator technology for 68 Ga production, favorable chemistry of 68 Ga for radio-complexation have paved the way for emerging applications of 68 Ga radiopharmaceuticals [59]. The most stable oxidation state of gallium in aqueous solution is +3 and its coordination number is 6.…”

Section: Ga For Manymentioning

confidence: 99%

Radiolabeled Dendrimers as Potential PET Agents for Molecular Imaging of Tumor Angiogenesis

Ghai¹,

Singh²,

Chopra³

et al. 2018

Dendrimers - Fundamentals and Applications

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Introduction: Angiogenesis is a normal physiological process that plays an imperative role during tumor development. We believe that the development of a non-invasive imaging technique targeting angiogenesis can provide a better understanding of this important process. Positron emission tomography (PET) -a highly sensitive imaging technique can offer accurate degree of disease quantification. The phenomenon of enhanced permeability and retention effect (EPR effect) is now becoming the gold standard in cancer targeting drug designing. Dendrimers have the ability to exhibit EPR effect for targeted therapeutic/drug delivery approach. Therefore, molecular imaging of tumor angiogenesis using radio-labeled dendrimers is expected to broaden the possibilities for drug development. Body:In the present chapter, the significance of performing conjugation chemistry of bifunctional chelators quality control parameters of the radiolabeled dendrimer conjugates in vitro stability, animal biodistribution, radiation dosimetry and molecular imaging of animal tumor model after injecting radiotracer have also been discussed in detail. Conclusion:Conjugation of the radio-metal complexes to larger molecules like dendrimers has created a new domain of research in the field of biomedical applications. Therefore, it has been proposed to develop new effective targeting moieties suitable for radiolabeling with PET tracers so as to perform molecular imaging studies.

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Radiolabeling optimization and characterization of 68 Ga labeled DOTA–polyamido-amine dendrimer conjugate – Animal biodistribution and PET imaging results

Cited by 44 publications

References 30 publications

Dendrimers: Breaking the paradigm of current musculoskeletal autoimmune therapies

Dendrimers: Breaking the paradigm of current musculoskeletal autoimmune therapies

PAMAM dendrimer based targeted nano-carrier for bio-imaging and therapeutic agents

Radiolabeled Dendrimers as Potential PET Agents for Molecular Imaging of Tumor Angiogenesis

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