Radiolabelled somatostatin analogs for diagnosis and radio-guided surgery of neuroendocrine breast cancer undetectable with conventional imaging procedures

Panareo, Stefano; Carcoforo, Paolo; Lanzara, Serena; Corcione, Stefano; Bagatin, E.; Casali, Massimiliano; Costanzo, Alessandro; Basaglia, Ernesto; Feggi, Luciano

doi:10.1016/j.breast.2007.08.002

Cited by 13 publications

(9 citation statements)

References 21 publications

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“…With the advance of modern technology, there has been a renewed interest for this surgical methodology. This has resulted in the first ex vivo experiments of modern β − radioguided surgery using 90 Y-DOTATOC in meningioma [143]. Topic-specific literature is provided by Heller et al, Daghighian [144], PVC [136] and ABS [143].…”

Section: Beta+ (β+) and Beta-(β-) Probesmentioning

confidence: 99%

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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Introduction: Radioguided surgery is an ever-evolving part of nuclear medicine. In fact, this nuclear medicine sub-discipline actively bridges non-invasive molecular imaging with surgical care. Next to relying on the availability of radio-and bimodal-tracers, the success of radioguided surgery is for a large part dependent on the imaging modalities and imaging concepts available for the surgical setting. With this review, we have aimed to provide a comprehensive update of the most recent advances in the field. Areas covered: We have made an attempt to cover all aspects of radioguided surgery: 1) the use of radioisotopes that emit γ, β + , and/or β − radiation, 2) hardware developments ranging from probes to 2D cameras and even the use of advanced 3D interventional imaging solutions, and 3) multiplexing solutions such as dual-isotope detection or combined radionuclear and optical detection. Expert opinion: Technical refinements in the field of radioguided surgery should continue to focus on supporting its implementation in the increasingly complex minimally invasive surgical setting, e.g. by accommodating robot-assisted laparoscopic surgery. In addition, hybrid concepts that integrate the use of radioisotopes with other image-guided surgery modalities such as fluorescence or ultrasound are likely to expand in the future.

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Section: Beta+ (β+) and Beta-(β-) Probesmentioning

confidence: 99%

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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“…Interest in this clinical field has already been demonstrated by previous studies on the use of RGS with octreotide labeled with the g-emitting 111 In in gastroenteropancreatic (8), lung (9), and breast cancer (10) and in nonmalignant cells surrounding neoplastic tissues (11). This paper reports our assessment of the potentiality of RGS with 90 Y-DOTATOC in NETs: evaluation of the tumor-to-nontumor ratio (TNR) and the kinetics in lesioned and healthy tissues.…”

mentioning

confidence: 98%

Time Evolution of DOTATOC Uptake in Neuroendocrine Tumors in View of a Possible Application of Radioguided Surgery with β⁻ Decay

et al. 2015

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A novel radioguided surgery (RGS) technique exploiting β − radiation has been proposed. To develop such a technique, a suitable radiotracer able to deliver a β − emitter to the tumor has to be identified. A first candidate is represented by 90 Y-labeled DOTATOC, a compound commonly used today for peptide radioreceptor therapy. The application of this β − RGS to neuroendocrine tumors (NET) requires study of the uptake of DOTATOC and its time evolution both in tumors and in healthy organs and evaluation of the corresponding performance of the technique. Methods: Uptake by lesions and healthy organs (kidneys, spleen, liver and healthy muscle) was estimated on 177 Lu-DOTATOC SPECT/CT scans of 15 patients affected by NET with different localizations, treated at IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. For each patient, SPECT/CT images, acquired at 0.5, 4, 20, 40, and 70 h after injection, were studied. For each lesion, the tumor-tonontumor ratio (TNR) with respect to all healthy organs and its time evolution were studied. A subset of patients showing hepatic lesions was selected, and the TNR with respect to the nearby healthy tissue was calculated. By means of a Monte Carlo simulation of the probe for β − RGS, the activity that is to be administered for a successful detection was estimated lesion-by-lesion. Results: Uptake of DOTATOC on NETs maximized at about 24 h after injection. The cases of hepatic lesions showed a TNR with respect to the tumor margins compatible with the application of β − RGS. In particular, 0.1-mL residuals are expected to be detectable within 1 s with 5% false-negative and 1% false-positive by administering the patient as little as 1 MBq/kg. Conclusion: The balance between tumor uptake and metabolic washout in healthy tissue causes the TNR to increase with time, reaching its maximum after 24 h, and this characteristic can be exploited when a radiotracer with a long halflife, such as 90 Y, is used. In particular, if 90 Y-DOTATOC is used with liver NET metastases, the proposed RGS technique is believed to be feasible by injecting an activity that is one third of that commonly used for PET imaging.

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“…So far, the world literature describes dozens, approx. 30, of single cases from multiple centres [8,[14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

“…Most NET cases is diagnosed using palpation testing along with diagnostic imaging, ultrasound and/ or mammography [13,16,17] . Only minor changes were detected using MRI or radionuclide imaging methods (In-111 pentetrotide scan).…”

Section: Discussionmentioning

confidence: 99%

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Neuroendocrine Carcinoma of the Breast – Preliminary Analysis of Treatment Results of 30 Patients

2017

ARC Journal of Gynecology and Obstetrics

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Radiolabelled somatostatin analogs for diagnosis and radio-guided surgery of neuroendocrine breast cancer undetectable with conventional imaging procedures

Cited by 13 publications

References 21 publications

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Time Evolution of DOTATOC Uptake in Neuroendocrine Tumors in View of a Possible Application of Radioguided Surgery with β⁻ Decay

Neuroendocrine Carcinoma of the Breast – Preliminary Analysis of Treatment Results of 30 Patients

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Radiolabelled somatostatin analogs for diagnosis and radio-guided surgery of neuroendocrine breast cancer undetectable with conventional imaging procedures

Cited by 13 publications

References 21 publications

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Time Evolution of DOTATOC Uptake in Neuroendocrine Tumors in View of a Possible Application of Radioguided Surgery with β− Decay

Neuroendocrine Carcinoma of the Breast – Preliminary Analysis of Treatment Results of 30 Patients

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Time Evolution of DOTATOC Uptake in Neuroendocrine Tumors in View of a Possible Application of Radioguided Surgery with β⁻ Decay