Radiolanthanide-labeled HA particles in the treatment of rheumatoid arthritis: ready-to-use cold kits for rapid formulation in hospital radiopharmacy

Production of 177Lu for Targeted Radionuclide Therapy: Available Options

“…The in vivo applications of key 177 Lu radiopharmaceuticals for a variety of therapeutic procedures include peptide receptor radionuclide therapy [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], bone pain palliation [27][28][29][30][31][32][33], radiation synovectomy [34][35][36][37][38][39] and radioimmonutherapy [40][41][42][43][44][45][46]. There is a steadily expanding list of 177 Lu-labeled radiopharmaceuticals that is currently being evaluated at the preclinical research or at product development stages; these may potentially be used in vivo in humans for evaluation for radionuclide therapy [1][2][3].…”

Barium titanate microparticles as potential carrier platform for lanthanide radionuclides for their use in the treatment of arthritis

“…[1][2][3][4][5][6] The key determinants for the success of RSV are the selection of an appropriate radionuclide and a biocompatible carrier platform which results in robust and irreversible binding with the radionuclide. 4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] This is attributed to the availability of a package of therapeutically useful radionuclides among lanthanide elements having a wide range of energy (0.34-2.28 MeV) of β − emission along with other desirable decay characteristics. 2,3,7-9 As for example, radionuclide emitting β − having maximum energy more than 1.5 MeV would be suitable for knee and hip joints, while medium energy β − emitters (maximum energy 0.5-1.0 MeV) would be suitable for ankle, elbow, and wrist joints and low energy β − emitters (maximum energy less than 0.5 MeV) for finger joints.…”

“…2,3,7-9 As for example, radionuclide emitting β − having maximum energy more than 1.5 MeV would be suitable for knee and hip joints, while medium energy β − emitters (maximum energy 0.5-1.0 MeV) would be suitable for ankle, elbow, and wrist joints and low energy β − emitters (maximum energy less than 0.5 MeV) for finger joints. 7,10,11,15,19,20 In the present work, our aim was to put forward an innovative and effective carrier platform on which lanthanide ions can be easily loaded and the loaded particles of appropriate size could be used to deliver cytotoxic dose to the diseased synovium after loco-regional administration. Based on these considerations, a plethora of therapeutic radionuclides have been proposed and clinically utilized in RSV, among which radionuclide of lanthanide elements such as 90 Y (yttrium is considered as a pseudolanthanide), 153 Sm, 165 Dy, 166 Ho, 169 Er, and 177 Lu (Table 1) are prominent ones.…”

“…Based on these considerations, a plethora of therapeutic radionuclides have been proposed and clinically utilized in RSV, among which radionuclide of lanthanide elements such as 90 Y (yttrium is considered as a pseudolanthanide), 153 Sm, 165 Dy, 166 Ho, 169 Er, and 177 Lu ( Table 1) are prominent ones. 4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] This is attributed to the availability of a package of therapeutically useful radionuclides among lanthanide elements having a wide range of energy (0.34-2.28 MeV) of β − emission along with other desirable decay characteristics. Treatment of the chronic inflammatory disease affecting different joints of human body (viz.…”

“…Additionally, all these radionuclide can be produced in required quantity and adequate radionuclidic purity in a nuclear reactor with moderate thermal neutron flux. 7,10,11,15,19,20 In the present work, our aim was to put forward an innovative and effective carrier platform on which lanthanide ions can be easily loaded and the loaded particles of appropriate size could be used to deliver cytotoxic dose to the diseased synovium after loco-regional administration. This single carrier platform would result in a series of radiolanthanide-loaded particulates which can be used for different joints of human body based on the energy of β − emission of the radionuclide ( 166 Ho for knee and hip, 153 Sm for ankle and elbow, 177 Lu for elbow and wrist, 169 Er for finger).…”