Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study

Kotecki, Mateusz; Gasik, Robert; Głuszko, Piotr; Sudoł‐Szopińska, Iwona

doi:10.3390/jcm10194587

Cited by 8 publications

(16 citation statements)

References 38 publications

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“…Risk variables for spinal cord participation included long illness history, RF seropositivity, and elevated inflammatory biomarkers. The primary drawback of radiography is the obscuration of anatomic structures caused by the superimposition of morphological characteristics utilized as measuring points of reference [ 14 ].…”

Section: Related Workmentioning

confidence: 99%

[Retracted] A Feasible Multimodal Photoacoustic Imaging Approach for Evaluating the Clinical Symptoms of Inflammatory Arthritis

Rajasekar

Nirmala

Bhuvaneswari

et al. 2022

BioMed Research International

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Numerous traditional medical imaging methods, including computed tomography with X-rays, positron emission tomography (PET), and magnetic resonance imaging (MRI), are utilized frequently in medical settings to screen for illnesses, diagnose patients, and track the effectiveness of treatments. When examining bone protrusions, CT is preferred over MRI for scanning connective tissue. Although the picture quality of PET is inferior to that of CT and MR, it is outstanding for detecting the molecular markers and metabolic functions of illnesses. To give high-resolution structural pictures and improved ailment sensitivity and specificity within another image, multimodal data and substantial therapeutic influence on advanced diagnostics and therapeutics have been used. The goal was to evaluate the clinical significance of multimodal photoacoustic/ultrasound (PA/US) articular imaging scoring, a cutting-edge image technique that may show the microvessels and oxygen levels of rheumatoid arthritis-related inflamed joints (RA). The PA/US imaging technology analyzed seven tiny joints. The PA and power Doppler (PD) impulses were semiquantified using a 0–3 grading scale, and the averages of the PA and PD scores for the seven joints are computed. Three PA+SO2 types were found determined by the relative oxygen levels (SO2) measurements of the affected joints. Researchers evaluated the relationships between the disease activity ratings and the PA/US imaging ratings. The PA scores and medical ratings that reflect the extent of the pain have strong relationships with each other, as do the PA+SO2 combinations. PA may be clinically useful in assessing RA. Thus, the research evaluated the clinical symptoms of inflammatory arthritis using a multimodal photoacoustic image process.

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Section: Related Workmentioning

confidence: 99%

[Retracted] A Feasible Multimodal Photoacoustic Imaging Approach for Evaluating the Clinical Symptoms of Inflammatory Arthritis

Rajasekar

Nirmala

Bhuvaneswari

et al. 2022

BioMed Research International

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“…(2011). However, these findings are divergent in other studies (Kotecki et al., 2021; Mathews, 1969; Weissman et al., 1982; Zhu et al., 2017).…”

Section: Discussionmentioning

confidence: 72%

“…Several studies reported a strong association between adherence to Methotrexate and decreased AAS risk (Kotecki et al., 2021; Weinblatt, 2013). In this regard, our study showed that only 66.6% of the study population were on Methotrexate at the time of AAS diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Cervical Spine involvement, often overlooked, represents the third articular feature of the disease after hands and feet. According to the literature, the prevalence of cervical spine instability during RA ranges from 17% to 88% (Kotecki et al., 2021; Zhu et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Anterior AAS is the most common form of and affects between 20% and 50% of patients with established RA (Kotecki et al, 2021). In contrast, VS is less common and occurs in about 10% of cases.…”

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confidence: 99%

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Predictors factors of atlanto‐axial subluxation in Tunisian patients with rheumatoid arthritis

Bettaieb

Ferjani

Nessib

et al. 2023

Musculoskeletal Care

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BackgroundThe aim of this study was to describe clinical and imaging features of atlantoaxial subluxation (AAS) and the associated risk factors in patients with rheumatoid arthritis (RA).MethodsWe conducted a retrospective and comparative study including 51 RA patients with AAS and 51 RA patients without AAS. Atlantoaxial subluxation was defined by the presence of an anterior C1C2 diastasis on the cervical spine radiograph in hyperflexion and/or an anterior, posterior, lateral or rotatory C1C2 dislocation on MRI with/without inflammatory signal.ResultsIn G1, clinical presentations revealing AAS were mainly neck pain (68.7%) and neck stiffness (29.8%). MRI revealed: diastasis C1C2 (92.5%), periodontoid pannus (92.5%), odontoid erosion (23.5%), vertical subluxation (9.8%) and spinal cord involvement (7.8%). A collar immobilisation and corticosteroid boluses were indicated in 86.3% and 47.1% of cases. C1‐C2arthrodesis was performed in 15.4% of cases. Atlantoaxial subluxation was significantly associated with: age at disease onset (p = 0.009), history of joint surgery (p = 0.012), disease duration (p = 0.001), rheumatoid factor (p = 0.01), anti‐cyclic citrullinated peptide (p = 0.02), erosive radiographic status (p < 0.005), coxitis (p < 0.001), osteoporosis (p = 0.012), extra‐articular manifestations (p < 0.001), and high disease activity (p = 0.001). Multivariate analysis identified RA duration (p < 0.001, OR = 1.022 CI[1.01–1.034]) and erosive radiographic status (p = 0.01, OR = 21.236 CI[2.05–219.44]) as predictive factors of AAS.ConclusionOur study showed that longer disease duration and joint destruction are the major predictive factors of AAS. Early treatment initiation, tight‐control and regular monitoring of cervical spine involvement are required in these patients.

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Prevalence of anterior atlantoaxial subluxation and association with established rheumatoid arthritis

Alp,

Cinakli,

Akar

et al. 2024

Musculoskeletal Care

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ObjectiveSpinal involvement in rheumatoid arthritis (RA) is limited to the upper cervical spine, leading to cervical spine instability. This study aimed to evaluate the prevalence of anterior atlantoaxial subluxation (aAAS) and its associated risk factors in patients with RA.MethodThis single‐centre cross‐sectional study 240 patients consecutively were recruited. Radiographs of the cervical spine were obtained in the flexion and neutral neck positions and read by two blinded observers. The diagnosis of aAAS was based on the distance between the anterior aspect of the dens and the posterior aspect of the anterior arch of the atlas, which was >3 mm during flexion. Statistical analysis was performed to determine the predictive factors of aAAS.ResultsTwo hundred and forty patients with a mean ± SD age of 56.4 ± 11.4 years were recruited, and 191 (78%) were female. The mean ± SD duration of the disease was 10.2 ± 8.5 years. Of all 25 cases (10.4%) diagnosed with aAAS, the mean anterior atlantodental interval in patients with AAS was 4.19 ± 1.20 mm. One in three patients with aAAS had no neck pain. Patients with aAAS had longer disease duration, lower age at diagnosis, lower body mass index, higher anti‐cyclic citrullinated peptide autoantibodies (anti‐CCP), more frequent erosion, joint restriction, and joint prostheses. In the multivariate regression model, joint limitation, history of joint prostheses, low BMI, and higher anti‐CCP levels were independent predictors of the aAAS.ConclusionThirty‐three percent of patients with cervical involvement do not experience neck pain. Cervical involvement should be considered even without neck pain, particularly in established diseases.

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Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study

Cited by 8 publications

References 38 publications

[Retracted] A Feasible Multimodal Photoacoustic Imaging Approach for Evaluating the Clinical Symptoms of Inflammatory Arthritis

[Retracted] A Feasible Multimodal Photoacoustic Imaging Approach for Evaluating the Clinical Symptoms of Inflammatory Arthritis

Predictors factors of atlanto‐axial subluxation in Tunisian patients with rheumatoid arthritis

Prevalence of anterior atlantoaxial subluxation and association with established rheumatoid arthritis

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