Radiological Investigations

Immature brains don't need GABA to get ‘hyper’‐excited

“…One major consequence of this phenomenon is that immature networks are, by nature, more excitable than mature networks. The pathophysiological correlate of this is that immature brains are more susceptible to developing epileptic activity (Sperber et al 1999). However, whether this hyperexcitability is mainly the consequence of particular excitability properties of individual neurons or of networks and whether it involves mainly excitatory or inhibitory neurons and/or synapses remain to be determined.…”