Radiologische Untersuchungsmethoden zur Frühdiagnose und Verlaufsbeurteilung experimentell induzierter Tumoren bei Ratte und Maus

Three groups of European hamster (EH) (Cricetus cricetus L.) were treated subcutaneously every two weeks for life with 1/10 or 1/20 LD50 DMH, while two other groups served as controls. Twelve weeks after commencement of treatment, radiological examinations of the colon and rectum were begun. The double contrast method was used. In this way it was possible to detect the earliest neoplastic alteration to take place in the above sites. This occurred in the 26th treatment week and was diagnosed as an adenocarcinoma. The technique used is simple, as well as being suitable for large numbers of animals. In addition, it allows for early experimental analysis of results in respect to latency period, growth rate, incidence and location of tumours.

show abstract

Radiological Detection and Sequential Observation of Experimentally Induced Bladder Tumours in the European Hamster

Eckel¹,

Reznik²,

Reznik-Schüller³

et al. 1974

Br J Cancer

View full text Add to dashboard Cite

Summary.-Four groups of European hamsters (strain MHH: EPH) were treated subcutaneously once weekly for life with 1/20 or 1/40 the LD50 of DBN while another 2 groups served as controls. Three animals of each group were x-rayed every 2 weeks after i.v. injection of the contrast agent Urographin. By means of cystograms tumours of the urinary bladder were detected between the 20th and 26th weeks after beginning treatment when they had reached a diameter of 1-2 mm; their development was subsequently observed by periodical x-ray examinations. The technique described is simple and provides a valuable means for obtaining additional in vivo information concerning latency period, growth rate and identity of experimentally induced primary urinary bladder tumours in the European hamster.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Radiologische Untersuchungsmethoden zur Frühdiagnose und Verlaufsbeurteilung experimentell induzierter Tumoren bei Ratte und Maus

Cited by 3 publications

References 0 publications

Tumorinduktion bei Mäusen durch N-Methylbenzyl-nitrosamin in niedriger Dosierung

Tumorinduktion bei Mäusen durch N-Methylbenzyl-nitrosamin in niedriger Dosierung

Early X-ray detection of colonic and rectal tumours in European hamsters

Radiological Detection and Sequential Observation of Experimentally Induced Bladder Tumours in the European Hamster

Contact Info

Product

Resources

About