Radiology of gestational trophoblastic neoplasia

Allen, Steven; Lim, Adrian; Seckl, Michael J.; Blunt, Dominic; Mitchell, Adam

doi:10.1016/j.crad.2005.12.003

Cited by 112 publications

(156 citation statements)

References 84 publications

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“…The signal void foci over the uterine wall and the high-flow vasculatures at the left adnexal region signified angiogenesis and neovascularisation, thus the hypervascular nature of the tumour. 1 This is in accordance with the characteristic hypervascularity of choriocarcinoma. 5,6 The multiple nodular opacities on chest X-ray most likely represented lung metastases, although histological confirmation was not performed.…”

Section: Discussionsupporting

confidence: 68%

“…3 Our case was very unusual as it occurred in the vagina. The most common site of metastasis for choriocarcinoma is lung, 1 and this also occurred in our patient.…”

Section: Discussionmentioning

confidence: 84%

“…The cause of such variation is not well understood. 1 Choriocarcinoma is a malignant form of gestational trophoblastic neoplasia, and generally arises in the uterine corpus of women of reproductive age with coincident or antecedent pregnancy. Primary extrauterine choriocarcinoma is rare and most reported cases have occurred in the uterine cervix.…”

Section: Discussionmentioning

confidence: 99%

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Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings

Wong¹,

Fung²,

Yung³

2016

Hong Kong Med J

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A 33-year-old nulligravid Filipino woman was admitted to the gynaecology ward of Princess Margaret Hospital in April 2014, with lower abdominal pain and recurrent retention of urine. Her pregnancy test was positive. Per-vaginal examination revealed a 4-cm firm, fixed, and wide-based vaginal mass with smooth wall over the upper anterior vagina. Bedside transabdominal ultrasonography confirmed a 4.5-cm solid mass in the anterior vagina and a 3. <5.0 IU/L for non-pregnant women), and repeated checking 3 days later was 253 957 IU/L. Alphafetoprotein, carcinoembryonic antigen, and Ca-125 were negative. A urologist was consulted and the patient underwent flexible cystoscopy that revealed indentation of the urinary bladder by an external mass. Mild erythematous changes were visualised at the right urinary bladder base. Biopsy revealed inflammation but no malignant cells.Magnetic resonance imaging (MRI) of the pelvis revealed a 4.8 cm x 5.2 cm x 4 cm (craniocaudal x anteroposterior x transverse) mass located at the anterior aspect of the vagina. It was hypointense with a faint hyperintense rim on T1-weighted images (Fig 1a) and heterogeneously hyperintense CASE REPORT

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Section: Discussionsupporting

confidence: 68%

“…3 Our case was very unusual as it occurred in the vagina. The most common site of metastasis for choriocarcinoma is lung, 1 and this also occurred in our patient.…”

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings

Wong¹,

Fung²,

Yung³

2016

Hong Kong Med J

View full text Add to dashboard Cite

show abstract

“…, 20 Accurate antepartum diagnosis depends on correlation with clinical findings and hCG levels 9 . CT scanning reveals the hypervascular metastatic lesions of choriocarcinoma well and is the most suitable method for evaluation of common metastatic sites 19 . MRI is usually reserved for equivocal cases or evaluation of brain or vaginal metastases 9 and was not performed in this case.…”

Section: Discussionmentioning

confidence: 99%

The use of middle cerebral artery Doppler ultrasonography to guide delivery of a viable pregnancy complicated by metastatic gestational chroriocarinoma

Thagard

Dubil

Lee

et al. 2013

Australas J Ultrason Med

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Background: Choriocarcinoma is a rare, aggressive subtype of gestational trophoblastic neoplasia. The diagnosis of metastatic choriocarcinoma in the setting of a viable intrauterine pregnancy is exceedingly rare and often associated with feto‐maternal hemorrhage. Case: An otherwise healthy Gravida 1 Para 0 at 34 weeks gestational age presented with metastatic choriocarcinoma and a viable fetus. Measured Doppler peak systolic velocity of the middle cerebral artery was used to detect fetal anemia, thus optimising the timing of delivery. Conclusion: This is the first case report to our knowledge using Doppler ultrasonography to detect fetal anemia in an effort to guide delivery in a case of choriocarcinoma diagnosed during pregnancy. If choriocarcinoma is diagnosed during pregnancy, middle cerebral artery Doppler ultrasonography may serve as a critical tool to help detect anemia, allowing pregnancy prolongation to promote fetal maturity while screening for the development of feto‐maternal hemorrhage.

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“…PET is a noninvasive method for studying biochemical and metabolic changes in cancer tissue, as they reflect growth or regression of tumors. Yet, there are limited data on the efficacy of PET in the evaluation of metastatic GTN, with studies limited to case reports and small case series (11)(12)(13)(14). Sironi et al (15).…”

Section: Discussionmentioning

confidence: 99%

Gestational trophoblastic disease with pulmonary and cerebral metastasis: Can fluorodeoxyglucose positron emission tomography really detect cranial metastatic disease ?

UYSAL¹

2016

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Gestational trophoblastic neoplasms (GTN) originate from placental tissue and usually metastasizes because of its propensity for early vascular invasion. Intracranial metastases are relatively uncommon. There are limited data on the efficacy of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of metastatic GTN. We present a case of GTN with simultaneous pulmonary and cranial metastases in which the cranial metasteses were undetectable with positron emission tomography (PET) scan.Key Words: Gestational Trophoblastic Neoplasms, Cranial Metastasis, Positron Emission Tomography Gestasyonel Trofoblastik Neoplaziler (GTN) plasenta dokusundan köken alırlar ve erken vasküler invazyon yaptıklarından sıklıkla metastaz yaparlar. Beyin metastazı nadir görülür. Metastatik GTN'nin taranmasında 18-florodeoksiglukoz pozitron emisyon tomografisinin (FDG-PET) etkinliği konusunda veriler yetersizdir. Bu olgu sunumunda, eş zamanlı akciğer ve beyin metastazı olan ve beyin metastazının FDG-PET ile saptanamadığı bir GTN olgusunu sunuyoruz.

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Radiology of gestational trophoblastic neoplasia

Cited by 112 publications

References 84 publications

Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings

Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings

The use of middle cerebral artery Doppler ultrasonography to guide delivery of a viable pregnancy complicated by metastatic gestational chroriocarinoma

Gestational trophoblastic disease with pulmonary and cerebral metastasis: Can fluorodeoxyglucose positron emission tomography really detect cranial metastatic disease ?

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