Radiology–Pathology Conference

Dickson, Asante M.; Schuss, Allan; Goyal, Amit; Katz, Douglas S.

doi:10.1016/j.clinimag.2004.04.001

Cited by 12 publications

(5 citation statements)

References 11 publications

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“…Most calcifications within GIST are circumscribed and patchy type. Previous episodes of bleeding or tumor necrosis with cystic degeneration may cause calcification[9-11]. In our case, the CT scan 2 years ago showed a cystic tumor with well circumscribed calcification in the stomach, but with greater thickness over the dependent part.…”

Section: Discussionmentioning

confidence: 62%

“…At least three types of calcification have been reported in gastric cancer: mucin pool calcifications, psammomatous calcifications, and heterotopic ossification[9,12]. In addition, four mechanisms of calcification within tumor have been suggested: (a) calcified scar tissue or granulomatous disease is engulfed by the tumor; (b) dystrophic calcification occurs within the areas of tumor necrosis; (c) calcium is deposited within the tumor as a result of a secretory function of the carcinoma; (d) metastatic calcification occurs as a result of hypercalcemia[13,14].…”

Section: Discussionmentioning

confidence: 99%

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Thick calcification from a GIST of the stomach penetrating into pericolic soft tissue - report of a case

Hwang

et al. 2011

World J Surg Onc

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Thick calcification is a rare presentation of gastrointestinal stromal tumor (GIST). Penetration into gastric mucosa and pericolic soft tissue has never been reported. We report a case of gastric GIST with cystic degeneration and thick calcification in an 81-year old female, who presented with hematemesis and severe abdominal pain. Thick calcification of this tumor penetrating into pericolic soft tissue was noted and successfully treated by distal gastrectomy and partial colectomy. For gastrointestinal tumors with thick calcification, even with benign behavior, surgical intervention should be considered for both oncological considerations and prevention of catastrophes like perforation or penetration into surrounding soft tissue.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Thick calcification from a GIST of the stomach penetrating into pericolic soft tissue - report of a case

Hwang

et al. 2011

World J Surg Onc

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“…Results from our study are necessarily associated with physiological disturbance in the blood calcium and phosphate or pathological condition such as chronic kidney disease or tumor, which can be concomitant in animals without clinical signs. Some previous studies have claimed that several gastrointestinal tumors may also contain calcification [ 24 ]. Moreover, some mechanisms of calcification in tumors have been suggested [ 25 ]: (a) Calcium salts are deposited within the tumor as an outcome of a secretory function of the carcinoma, (b) dystrophic calcification happens within sites of tumor necrosis, and (c) metastatic calcification occurs as a consequence of hypercalcemia.…”

Section: Discussionmentioning

confidence: 99%

Detection of esophageal and glandular stomach calcification in cow (Bos taurus)

2020

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Aim: The aims of this study were first to estimate calcification in the esophagus and abomasum of cows and second to quantify its appearance with increasing age using histopathological and immunohistochemical techniques. Materials and Methods: Esophageal and abomasal samples from 24 healthy cows (Bos taurus) were collected. Hematoxylin and eosin, alizarin red, and von Kossa stains were used for histopathological analysis. Histopathological changes were confirmed with immunohistochemical staining, followed by digital image analysis. Results: Histological findings revealed the esophagus and abomasum wall comprised four fundamental layers, the mucosa, submucosa, muscularis, and serosa or adventitia. At 1 year old, calcification was beginning to appear as fine diffused points in mucosa, submucosa, and muscularis of both esophagus and abomasum, appearing as small spots at 2 years old. With advancing age in all animals, this calcification began to appear as medium spots spread throughout all wall layers of these organs at 3 years old. By 4 years old, calcification had evolved into large dark foci spread substantially throughout the tunica submucosa and tunica muscularis. Immunohistochemical results exhibited positive immunoreaction to calcium salts in the esophagus and abomasum layers in all animals, which increased with age. Conclusion: The current study concluded that calcification is a pathological event appearing spontaneously in various types of soft tissue, significantly increasing with age, either because of hypercalcemia and hyperphosphatemia or secondary to other diseases.

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“…For example, diffuse and punctate calcifications may accompany mucin-producing adenocarcinoma of the stomach[24,25]. In the pancreas, solid pseudopapillary tumors and mucinous cystic neoplasms may develop peripheral curvilinear wall calcification, whereas serous cystadenomas may have central calcification within the central fibrous scar[26].…”

Section: Discussionmentioning

confidence: 99%

Heavily calcified gastrointestinal stromal tumors: Pathophysiology and implications of a rare clinicopathologic entity

Salati¹,

Orsi²,

Bonetti³

et al. 2017

WJGO

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls. Herein, we report a gastric GIST with the unusual presentation of prominent calcifications that was identified incidentally on imaging during a post-trauma diagnostic work-up. The patient underwent laparoscopic surgery with a radical resection of the mass, which was subsequently characterized by histological analysis as spindle-shaped tumor cells, positive for CD117/c-KIT, CD34 and DOG1, and with calcified areas. Given the intermediate risk of recurrence, no adjuvant therapy was recommended and the patient underwent regular follow-up for 22 mo, with no evidence of relapse. Our case can be considered of interest because of the rarity of clinical presentation and the uniquely large size of the GIST at diagnosis (longest diameter exceeding 9 cm). In closing, we discuss the pathophysiology and clinical implications of calcifications in GISTs by reviewing the most up-to-date relevant literature.

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Radiology–Pathology Conference

Cited by 12 publications

References 11 publications

Thick calcification from a GIST of the stomach penetrating into pericolic soft tissue - report of a case

Thick calcification from a GIST of the stomach penetrating into pericolic soft tissue - report of a case

Detection of esophageal and glandular stomach calcification in cow (Bos taurus)

Heavily calcified gastrointestinal stromal tumors: Pathophysiology and implications of a rare clinicopathologic entity

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