Radiolysis of polychlorodibenzodioxins in hexane

Mitroshkov, Alexandre V.; Revel'skii, I. A.; Podsoblyaev, A. P.; Егоров, В. В.; Kostyanovskii, R. G.

doi:10.1007/bf00958555

Cited by 1 publication

(3 citation statements)

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“…A similar reaction (dechlorination and solvent adduct formation) has been reported for the photolysis of octachlorodibenzo-p-dioxin in benzene (36). Irradiation of TCDD in hexane with γ radiation also resulted in dechlorination but with addition of a 1 H through reaction of the [ 3 H]TriCDD free radical with the alkane solvent (37). Increasing concentrations of [ 3 H]TriCDD after purification of solutions indicated that the [ 3 H]TriCDD free radicals caused by radiolysis could also react with toluene by abstracting a hydrogen from the methyl group.…”

Section: Table 1 Specific Activity and Radiopurity Analyses Of Toxici...supporting

confidence: 65%

“…Hydrogen Isotope Ratios Associated with [ 3 H] TCDD. The three analogues of TCDD that result from 3 H labeling at the 1,6 dibenzo-p-dioxin positions, [ 3 H0,1,2]TCDD, alter the typical molecular ion distribution produced by 35 Cl and 37 Cl in the mass spectrum as shown in Figure 1a,b. High mass resolution (R ) 30 000) SIM analysis of solution A resulted in good agreement with mole ratios for the three [ 3 H]TCDD analogues determined with the low resolution method, which was required for detection of trace concentrations in tissue samples.…”

Section: Resultsmentioning

confidence: 99%

“…Each analogue produces a cluster of molecular ions which result from the presence of the naturally occurring isotopes of chlorine and carbon (Figure 1a). The analytical challenge arises from the similarity between the differences in mass units for 35 Cl and 37 Cl (1.9970 amu) and 1 H and 3 H (2.0082 amu). The major ions of these clusters occur at the even nominal masses in the range from m/z 320 to 330 (Figure 1b).…”

Section: Methodsmentioning

confidence: 99%

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Temporal Changes in Purity and Specific Activity of Tritium-Labeled 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Radiopurity Model for Toxicology

Fernandez

Cook

Butterworth

et al. 1999

Environ. Sci. Technol.

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The specific activity ( S ) and radiopurity ( R ) of tritium labeled 2,3,7,8-tetrachlorodibenzo-p-dioxin, [3H]TCDD, were measured by gas chromatography/mass spectrometry (GC/MS) while attempting to accurately characterize TCDD doses received by invertebrates, fish, and fish embryos during several toxicology studies conducted over a 3 year period. The [3H]TCDD sample was found to consist of six TCDD analogues involving hydrogen, deuterium, and tritium substitution at the 1,6-dibenzo-p-dioxin carbon positions and a complex mixture of impurities (with and without tritium labels). Planar aromatic impurities were identified as tolyl-TCDD adducts and appeared to result from the decay of 3H radiolabels to produce TCDD carbocations which reacted with the solvent, toluene. Formation of TriCDD and tolyl-TriCDDs, from both TCDD and tolyl-TCDDs, probably resulted from radiolysis-induced loss of a chlorine to form TriCDD free radicals which reacted with toluene. The measurement of S for [3H]TCDD by GC/MS was accurate and precise (±3%) because relative, rather than absolute, amounts of the analogues were determined. Changes in S over time were accurately modeled as a function of the conversion of each [3H]TCDD analogue to a solvent-TCDD analogue at a rate determined by 3H loss due to decay. Storage, purification, and use of tritiated chemicals for toxicology studies requires consideration of the 3H decay-related phenomena. For example, hydroxylated TCDD is an expected decay reaction product of [3H]TCDD in tissues and may be misidentified as a metabolite.

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Section: Table 1 Specific Activity and Radiopurity Analyses Of Toxici...supporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%