Radiomics analysis of multiparametric MRI for prediction of pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Cui, Yanfen; Yang, Xiaotang; Shi, Zhang; Yang, Zhao; Xiang-ke, DU; Zhao, Zhikai; Cheng, Xintao

doi:10.1007/s00330-018-5683-9

Cited by 187 publications

(156 citation statements)

References 41 publications

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“…Our study was in general consistent with prior researches. Nie and Cui reported a relatively satisfactory result by using a radiomics method, with AUCs of 0.84 and 0.94 for pCR prediction, respectively. However, there was an obvious predominance in our study compared to their studies.…”

Section: Discussionmentioning

confidence: 99%

Predicting pathological complete response by comparing MRI‐based radiomics pre‐ and postneoadjuvant radiotherapy for locally advanced rectal cancer

Liu

Pei

et al. 2019

Cancer Medicine

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BackgroundTotal mesorectal excision following neoadjuvant chemoradiotherapy (nCRT) is recommended in the latest treatment of locally advanced rectal cancer (LARC).ObjectiveTo predict whether patients with LARC can achieve pathologic complete response (pCR), comparing MRI‐based radiomics between before and after neoadjuvant radiotherapy (nRT) was performed.MethodsOne hundred and sixty‐five MRI‐based radiomics features in axial T2‐weighted images were obtained quantitatively from Imaging Biomarker Explorer Software. The specific features of conventional and developing radiomics were selected with the analysis of least absolute shrinkage and selection operator logistic regression, of which the predictive performance was analyzed with receiver operating curve and calibration curve, and applied to an independent cohort.ResultsOne hundred and thirty‐one target patients were enrolled in the present study. A radiomics signature founded on seven radiomics features was generated in the primary cohort. A remarkable difference about Rad‐score between pCR and non‐pCR group occurred in both of primary (P < .001) or validation cohorts (P < .001). The value of area under the curves was 0.92 (95% CI, 0.86‐0.99) and 0.87 (95% CI, 0.74‐1.00) in the primary and validation cohorts, respectively. The Rad‐score (OR = 23.581; P < .001) from multivariate logistic regression analysis was significant as an independent factor of pCR.ConclusionOur predictive model based on radiomics features was an independent predictor for pCR in LARC and could be a candidate in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Predicting pathological complete response by comparing MRI‐based radiomics pre‐ and postneoadjuvant radiotherapy for locally advanced rectal cancer

Liu

Pei

et al. 2019

Cancer Medicine

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“…After CRT, rectal cancers demonstrate variable degrees of tumor response, including pathologic complete response (pCR) in 15% to 27% of patients. [ 1 ] Patients with complete response (CR) or tumor downstaging after neoadjuvant CRT can achieve excellent local tumor control and a better quality of life, and organ-preserving treatments, such as watch-and-wait approach or local excision can be performed instead of TME. [ 2 , 3 ]…”

Section: Introductionmentioning

confidence: 99%

MR prediction of pathologic complete response and early-stage rectal cancer after neoadjuvant chemoradiation in patients with clinical T1/T2 rectal cancer for organ saving strategy

Bae¹,

Seo²,

Han³

et al. 2020

Medicine

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To evaluate the ability of magnetic resonance imaging (MRI) to predict pathologic complete response (pCR) after neoadjuvant chemoradiation therapy (CRT) in patients with clinical T1/T2 rectal cancer to indicate candidates for organ-saving strategies. Between 2012 and 2016, 38 patients with clinical T1/T2 rectal cancer received neoadjuvant CRT. Radiologic complete response (rCR) was assigned when dense fibrotic tissue without tumor signal intensity was observed on post-CRT MRI. Surgical pathologic assessment was used to evaluate tumor regression. The association between rCR and the mural extent of the primary tumor, pCR, and pathologic T stage were analyzed. In rCR patients, the pCR rate was higher; the odds of achieving pCR were 8.00 times higher than for non-rCR patients ( P = .02). rCR patients were also more likely to have early-stage cancer than non-rCR patients ( P = 0.01). Patients with partial extent of the primary tumor on post-CRT MRI were more likely to be diagnosed with early-stage cancer than those with transmural extent ( P = .01). rCR indicated by post-CRT MRI can be used as a supportive factor to predict pCR after neoadjuvant CRT in patients with clinical T1/T2 rectal cancer and can guide management decisions around organ-saving treatments.

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“…Approximately 20 percent of the rectal cancer patients have a good response to neoadjuvant chemoradiotherapy and the tumor disappear completely. This phenomenon is called clinical complete response(cCR) [5]. The stringent definition of cCR was proposed by Mass in 2012, and it contained five diagnostic criteria.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of wait and see strategy versus surgery for rectal cancer with cCR/near-cCR response after neoadjuvant chemoradiotherapy: a meta-analysis

zhao

Deng

et al. 2020

Preprint

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Background: To evaluate the efficacy and safety between wait and see strategy (WS) and surgery of rectal cancer patients with cCR/near-cCR response after neoadjuvant chemoradiotherapy.Methods: We searched PubMed, Cochrane Library, CNKI(China National Knowledge Infrastructure) and Wanfang databases to compare wait and see strategy with surgery for rectal cancer with cCR/near-cCR response after neoadjuvant chemoradiotherapy up to January 2020. We collected the data of local recurrence, distant metastasis, cancer related death, overall survival and diseasr-free survival and compared the advantages and disadvantages of the two groups.Results: 14 English studies with 3932 patients were included. There were 700 patients in WS group and 3232 patients in surgical group. WS group had higher local recurrence rate than surgery group(OR:3.55, 95% CI :2.35 to 5.36, P<0.001). WS group had better 2-year DFS(OR:0.74, 95% CI :0.56 to 0.96, P=0.03) and 2-year OS (OR:0.38, 95% CI :0.28 to 0.52, P<0.001) than surgery group. Subgroup analysis of WS group and radical surgery group also obtained the similar results. Eastern studies also supported the conclusion. There was no significant difference of other data between the two groups.Conslusion: Compared with surgery group, WS group would increase the risk of local recurrence rate, but WS group had better 2-year DFS and OS than surgery group. However, WS group did not increase the possibility of distant metastasis and cancer related death of the patients.

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Radiomics analysis of multiparametric MRI for prediction of pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Cited by 187 publications

References 41 publications

Predicting pathological complete response by comparing MRI‐based radiomics pre‐ and postneoadjuvant radiotherapy for locally advanced rectal cancer

Predicting pathological complete response by comparing MRI‐based radiomics pre‐ and postneoadjuvant radiotherapy for locally advanced rectal cancer

MR prediction of pathologic complete response and early-stage rectal cancer after neoadjuvant chemoradiation in patients with clinical T1/T2 rectal cancer for organ saving strategy

Efficacy and safety of wait and see strategy versus surgery for rectal cancer with cCR/near-cCR response after neoadjuvant chemoradiotherapy: a meta-analysis

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